| Revision as of 14:03, 8 August 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'DrugBank').← Previous edit |
Latest revision as of 15:40, 22 October 2024 edit undoCitation bot (talk | contribs)Bots5,418,815 edits Added pmid. | Use this bot. Report bugs. | Suggested by Dominic3203 | Category:Antihypertensive agent stubs | #UCB_Category 26/91 |
| (27 intermediate revisions by 20 users not shown) |
| Line 1: |
Line 1: |
|
{{chembox |
|
{{chembox |
|
| verifiedrevid = 443561394 |
|
| verifiedrevid = 443681733 |
|
|ImageFile=Debrisoquine.svg |
|
| ImageFile=Debrisoquine.svg |
|
|ImageSize= |
|
| ImageSize= |
|
|IUPACName=1,2,3,4-tetrahydroisoquinoline-2-carboximidamide |
|
| PIN=3,4-Dihydroisoquinoline-2(1''H'')-carboximidamide |
|
|OtherNames= |
|
| OtherNames= |
|
|Reference=<ref>, ].</ref> |
|
| Reference=<ref>, ].</ref> |
|
|Section1={{Chembox Identifiers |
|
|Section1={{Chembox Identifiers |
|
| UNII_Ref = {{fdacite|correct|FDA}} |
|
| UNII_Ref = {{fdacite|correct|FDA}} |
|
| UNII = X31CDK040E |
|
| UNII = X31CDK040E |
|
| KEGG_Ref = {{keggcite|correct|kegg}} |
|
| KEGG_Ref = {{keggcite|correct|kegg}} |
| Line 21: |
Line 21: |
|
| CASNo_Ref = {{cascite|correct|CAS}} |
|
| CASNo_Ref = {{cascite|correct|CAS}} |
|
| CASNo=1131-64-2 |
|
| CASNo=1131-64-2 |
|
| PubChem=2966 |
|
| PubChem=2966 |
|
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
|
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
|
| ChemSpiderID = 2860 |
|
| ChemSpiderID = 2860 |
|
| ChEBI_Ref = {{ebicite|correct|EBI}} |
|
| ChEBI_Ref = {{ebicite|correct|EBI}} |
|
| ChEBI = 34665 |
|
| ChEBI = 34665 |
|
|
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
|
| DrugBank = DB04840 |
|
| DrugBank = DB04840 |
|
| SMILES = =C(N)N2Cc1c(cccc1)CC2 |
|
| SMILES = =C(N)N2Cc1c(cccc1)CC2 |
|
| MeSHName=Debrisoquine |
|
| MeSHName=Debrisoquine |
|
}} |
|
}} |
|
|Section2={{Chembox Properties |
|
|Section2={{Chembox Properties |
|
| Formula=C<sub>10</sub>H<sub>13</sub>N<sub>3</sub> |
|
| Formula=C<sub>10</sub>H<sub>13</sub>N<sub>3</sub> |
|
| MolarMass=175.23032 |
|
| MolarMass=175.23032 |
|
| Appearance= |
|
| Appearance= |
|
| Density= |
|
| Density= |
|
| MeltingPt= |
|
| MeltingPt= |
|
| BoilingPt= |
|
| BoilingPt= |
|
| Solubility= |
|
| Solubility= |
|
}} |
|
}} |
|
|Section3={{Chembox Hazards |
|
|Section6={{Chembox Pharmacology |
|
|
| ATCCode_prefix = C02 |
| ⚫ |
| MainHazards= |
|
|
|
| ATCCode_suffix = CC04 |
| ⚫ |
| FlashPt= |
|
|
|
}} |
|
| Autoignition= |
|
|
|
|Section7={{Chembox Hazards |
|
⚫ |
| MainHazards= |
|
⚫ |
| FlashPt= |
|
|
| AutoignitionPt = |
|
}} |
|
}} |
|
}} |
|
}} |
|
|
|
|
|
'''Debrisoquine''' is a derivative of ]. It is an ] drug similar to ]. Debrisoquine is frequently used for phenotyping the ] enzyme, a drug metabolizing enzyme.<ref> |
|
'''Debrisoquine''' is a derivative of ]. It is an ] drug similar to ]. Debrisoquine is frequently used for ] the ] enzyme, a drug-metabolizing enzyme.<ref>{{Cite journal | last1 = Fuhr | first1 = U. | last2 = Jetter | first2 = A. | last3 = Kirchheiner | first3 = J. | doi = 10.1038/sj.clpt.6100050 | title = Appropriate Phenotyping Procedures for Drug Metabolizing Enzymes and Transporters in Humans and Their Simultaneous Use in the "Cocktail" Approach | journal = Clinical Pharmacology & Therapeutics | volume = 81 | issue = 2 | pages = 270–283 | year = 2007 | pmid = 17259951 }}</ref> |
|
|
|
|
|
|
Debrisoquine has been identified as a inhibitor of ] protease, which is involved in the ] process of ]. In a laboratory study, it showed antiviral activity by blocking the ability of the virus to enter human lung cells.<ref name="pmid37284689">{{cite journal |vauthors=Peiffer AL, Garlick JM, Wu Y, Wotring JW, Arora S, Harmata AS, Bochar DA, Stephenson CJ, Soellner MB, Sexton JZ, Brooks CL, Mapp AK |title=TMPRSS2 Inhibitor Discovery Facilitated through an In Silico and Biochemical Screening Platform |journal=ACS Medicinal Chemistry Letters |volume=14 |issue=6 |pages=860–866 |date=June 2023 |pmid=37284689 |pmc=10237299 |doi=10.1021/acsmedchemlett.3c00035}}</ref> |
| ⚫ |
==See also== |
|
| ⚫ |
* ] |
|
|
|
|
|
|
|
The ] part of the molecule also appears in ] and ].{{citation needed|date=August 2024}} The 7-bromo analog of debrisoquine is called ].{{citation needed|date=August 2024}} |
| ⚫ |
==References== |
|
|
{{reflist}} |
|
|
|
|
|
|
⚫ |
== See also == |
|
⚫ |
* {{section link|Isoquinoline|Applications of derivatives}} |
|
|
|
|
⚫ |
== References == |
|
|
{{Reflist}} |
|
|
|
|
|
{{Antihypertensives and diuretics}} |
|
{{Antihypertensives and diuretics}} |
|
|
|
|
|
|
] |
|
⚫ |
] |
|
] |
|
] |
|
] |
|
] |
| ⚫ |
] |
|
|
|
|
|
|
|
|
|