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Revision as of 15:15, 15 November 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'CAS_number').← Previous edit Latest revision as of 13:25, 25 March 2024 edit undoEcangola (talk | contribs)Extended confirmed users93,554 edits fmtTag: Visual edit 
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{{Short description|Chemical compound}}
{{Unreferenced stub|auto=yes|date=December 2009}}
{{Redirect-distinguish|Nepresso|Nespresso}}
{{Drugbox {{Drugbox
| Verifiedfields = changed | Verifiedfields = changed
| Watchedfields = changed | Watchedfields = changed
| verifiedrevid = 414423443 | verifiedrevid = 460786592
| IUPAC_name = 4-hydrazinyl-1-hydrazinylidene-1,2-dihydrophthalazine | IUPAC_name = 4-Hydrazinyl-1-hydrazinylidene-1,2-dihydrophthalazine
| image = Dihydralazine structure.svg | image = Dihydralazine.svg
| width = 125
| image2 = Dihydralazine-3D-balls.png
| width2 = 125


<!--Clinical data--> <!--Clinical data-->
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| Drugs.com = {{drugs.com|international|dihydralazine}} | Drugs.com = {{drugs.com|international|dihydralazine}}
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X --> | pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category = | pregnancy_category =
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S8 --> | legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S8 -->
| legal_UK = <!-- GSL / P / POM / CD --> | legal_UK = <!-- GSL / P / POM / CD -->
| legal_US = <!-- OTC / Rx-only --> | legal_US = <!-- OTC / Rx-only -->
| legal_status = | legal_status =
| routes_of_administration = | routes_of_administration =


<!--Pharmacokinetic data--> <!--Pharmacokinetic data-->
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| metabolism = | metabolism =
| elimination_half-life = | elimination_half-life =
| excretion = | excretion =


<!--Identifiers--> <!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}} | CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = <!-- blanked - oldvalue: 484-23-1 --> | CAS_number = 484-23-1
| ATC_prefix = C02 | ATC_prefix = C02
| ATC_suffix = DB01 | ATC_suffix = DB01
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 9813 | ChemSpiderID = 9813
| UNII_Ref = {{fdacite|changed|FDA}} | UNII_Ref = {{fdacite|correct|FDA}}
| UNII = PCU411F5L6 | UNII = PCU411F5L6
| KEGG_Ref = {{keggcite|correct|kegg}} | KEGG_Ref = {{keggcite|correct|kegg}}
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<!--Chemical data--> <!--Chemical data-->
| C=8 | H=10 | N=6 | C=8 | H=10 | N=6
| smiles = NNc1c2ccccc2C(=NN)Nn1
| molecular_weight = 190.205
| smiles = n2nc(c1ccccc1c2NN)NN
| InChI = 1/C8H10N6/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7/h1-4H,9-10H2,(H,11,13)(H,12,14)
| InChIKey = VQKLRVZQQYVIJW-UHFFFAOYAA
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C8H10N6/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7/h1-4H,9-10H2,(H,11,13)(H,12,14) | StdInChI = 1S/C8H10N6/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7/h1-4H,9-10H2,(H,11,13)(H,12,14)
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}} }}


'''Dihydralazine''' is a ]<ref name="lybrate">{{Cite web |title=Dihydralazine - Uses, Side Effects, Substitutes, Composition And More |url=https://www.lybrate.com/medicine/dihydralazine/ |access-date=2024-03-25 |website=Lybrate |language=en}}</ref> with ] properties.<ref>{{cite journal | vauthors = Stern HC, Matthews JH, Belz GG | title = Influence of dihydralazine induced afterload reduction on systolic time intervals and echocardiography in healthy subjects | journal = British Heart Journal | volume = 52 | issue = 4 | pages = 435–9 | date = October 1984 | pmid = 6477782 | pmc = 481656 | doi = 10.1136/hrt.52.4.435 }}</ref> It functions by combating the effects of adrenaline, and by expanding the blood vessels so as to enable smoother flow of blood by decreasing the pressure. It is generally administered orally, and is available in the form of tablets.<ref name=lybrate></ref> It belongs to the ] ].<ref name=Bourreli1988>{{cite journal | vauthors = Bourreli B, Pinaud M, Passuti N, Gunst JP, Drouet JC, Remi JP | title = Additive effects of dihydralazine during enflurane or isoflurane hypotensive anaesthesia for spinal fusion | journal = Canadian Journal of Anaesthesia | volume = 35 | issue = 3 ( Pt 1) | pages = 242–8 | date = May 1988 | pmid = 3383316 | doi = 10.1007/BF03010617 | doi-access = free }}</ref> It has very similar effects to ].<ref name=Bourreli1988/>
'''Dihydralazine''' is an ] of the ] ].


==See also== == Side Effects ==
*]<ref name=lybrate></ref>
* ]
*Loss of Appetite<ref name=lybrate></ref>
* ]
*]<ref name=lybrate></ref>
⚫ * ]
*]<ref name=lybrate></ref>
*]<ref name=lybrate></ref>
*]<ref name=lybrate></ref>
*Increased Heart Rate<ref name=lybrate></ref>
*]<ref name=lybrate></ref>


== Contraindications ==
⚫ ==References==
Contraindications to this drug include allergic reactions to this drug or to any of its components, ischemic heart diseases, coronary artery diseases, valvular stenosis, aortic aneurysms and pericarditis. Patients who have a previous medical history of kidney dysfunctions, liver damage, heart disorders and cerebro-vascular disorders must exercise caution while taking this medicine. Dihydralazine must not be prescribed to patients who are elderly, and to breastfeeding women. Caution must be exercised while prescribing this medicine to pregnant women.<ref name=lybrate></ref>
⚫ {{Reflist|2}}

== Other Important information on intake ==
'''When ending intake''', you are recommended to withdraw gradually from this medicine, as opposed to abruptly ceasing its intake. Heartbeat problems and edema may occur as adverse effects.<ref name=lybrate></ref>

== See also ==
⚫ *]

⚫ == References ==
⚫ {{Reflist}}

== Further reading ==
*https://go.drugbank.com/drugs/DB12945
*https://www.lybrate.com/medicine/dihydralazine


{{Nonsympatholytic vasodilatory antihypertensives}} {{Nonsympatholytic vasodilatory antihypertensives}}
{{Hydrazines}} {{Hydrazines}}


⚫ ]
⚫ ]
] ]
⚫ ]
] ]
⚫ ]



{{antihypertensive-stub}} {{antihypertensive-stub}}

]
]
]