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Dimetridazole: Difference between revisions

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Revision as of 05:40, 1 July 2011 editCheMoBot (talk | contribs)Bots141,565 edits Updating {{drugbox}} (changes to verified fields - updated '') per Chem/Drugbox validation (report errors or bugs)← Previous edit Latest revision as of 15:10, 21 February 2023 edit undoOzzie10aaaa (talk | contribs)Autopatrolled, Extended confirmed users, New page reviewers214,047 editsm Cleaned up using AutoEd 
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{{Short description|Chemical compound}}
{{drugbox
{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 437182923
| UNII_Ref = {{fdacite|changed|FDA}}
| IUPAC_name = 1,2-dimethyl-5-nitro-1''H''-imidazole
| UNII = K59P7XNB8X
| image = Dimetridazole structure.svg
| verifiedrevid = 414429001
| width = 160
| IUPAC_name = 1,2-Dimethyl-5-nitroimidazole

| image = Dimetridazole structure.svg
<!--Clinical data-->
| tradename =
| Drugs.com = {{drugs.com|international|dimetridazole}}
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category =
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status =
| routes_of_administration =

<!--Pharmacokinetic data-->
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =

<!--Identifiers-->
| CAS_number = 551-92-8
| CAS_supplemental =
| ATCvet = yes
| ATC_prefix = P51
| ATC_suffix = AA07
| ATC_supplemental =
| PubChem = 3090
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 2980 | ChemSpiderID = 2980
| UNII_Ref = {{fdacite|correct|FDA}}
| InChI = 1/C5H7N3O2/c1-4-6-3-5(7(4)2)8(9)10/h3H,1-2H3
| UNII = K59P7XNB8X
| InChIKey = IBXPYPUJPLLOIN-UHFFFAOYAK
| KEGG_Ref = {{keggcite|correct|kegg}}
| smiles1 = O=()c1cnc(n1C)C
| KEGG = D07855
| ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 38938 | ChEMBL = 38938

<!--Chemical data-->
| chemical_formula =
| C=5 | H=7 | N=3 | O=2
| smiles = Cc1ncc((=O)=O)n1C
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C5H7N3O2/c1-4-6-3-5(7(4)2)8(9)10/h3H,1-2H3 | StdInChI = 1S/C5H7N3O2/c1-4-6-3-5(7(4)2)8(9)10/h3H,1-2H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = IBXPYPUJPLLOIN-UHFFFAOYSA-N | StdInChIKey = IBXPYPUJPLLOIN-UHFFFAOYSA-N
| CAS_number = 551-92-8
| CAS_supplemental =
| ATCvet = yes
| ATC_prefix = P51
| ATC_suffix = AA07
| ATC_supplemental =
| PubChem = 3090
| DrugBank =
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D07855
| chemical_formula =
| C=5 | H=7 | N=3 | O=2
| molecular_weight = 141.128 g/mol
| smiles = Cc1ncc((=O)=O)n1C
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category=
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status =
| routes_of_administration =
}} }}
'''Dimetridazole''' is a drug that combats ] infections. It is a ] class drug. It has been banned by the ] government as a ] feed additive.


'''Dimetridazole''' is a drug that combats ] infections. It is a ] class drug.<ref>{{Cite journal
==External links==
| last1 = Dalton | first1 = P.
*
| title = Use of dimetridazole in gamebirds
| journal = The Veterinary Record
| volume = 139
| issue = 16
| pages = 399
| year = 1996
| pmid = 8913016
}}</ref> It used to be commonly added to poultry feed. This led to it being found in eggs. Because of suspicions of it being carcinogenic its use has been legally limited but it is still found in the eggs.<ref>{{cite journal |vauthors=Posyniak A, Semeniuk S, Zmudzki J, Niedzielska J, Biernacki B |title=Residues of dimetridazole in eggs after treatment of laying hens |journal=Veterinary Research Communications |volume=20 |issue=2 |pages=167–74 |year=1996 |pmid=8711897 |doi=10.1007/bf00385638|s2cid=38729121 }}</ref><ref>{{cite journal |vauthors=Cannavan A, Kennedy DG |title=Determination of dimetridazole in poultry tissues and eggs using liquid chromatography-thermospray mass spectrometry |journal=The Analyst |volume=122 |issue=9 |pages=963–6 |year=1997 |pmid=9374025 |doi=10.1039/a703193i|bibcode=1997Ana...122..963C }}</ref> It is now banned as a ] feed additive in many jurisdictions, for example in the ],<ref>Council Regulation (EEC) No 2377/90 of 26 June 1990 </ref> ].<ref> {{webarchive |url=https://web.archive.org/web/20050507140837/http://www.inspection.gc.ca/english/anima/feebet/mib/mibdime.shtml |date=May 7, 2005 }}</ref> and the ].<ref>US Food and Drugs Administration, Food Additives Status List </ref> In the US, the ] bans it for ]<ref>US Food and Drug Administration, Code of Federal Regulations, Title 21, Volume 6, Revised as of April 1, 2020 </ref>

==See also==
* ]
* ]

==References==
{{reflist}}


] ]
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