| Revision as of 13:52, 5 June 2011 editCheMoBot (talk | contribs)Bots141,565 edits Updating {{chembox}} (no changed fields - updated 'ImageFile_Ref', 'UNII_Ref', 'ChEMBL_Ref', 'KEGG_Ref') per Chem/Drugbox validation (report errors or [[u← Previous edit |
Latest revision as of 18:45, 5 April 2023 edit undoAdrianpip2000 (talk | contribs)98 editsm removed capitalization |
| (51 intermediate revisions by 36 users not shown) |
| Line 1: |
Line 1: |
|
{{chembox |
|
{{chembox |
|
|
| Watchedfields = changed |
|
| verifiedrevid = 402003070 |
|
| verifiedrevid = 432681189 |
|
| Reference=<ref></ref> |
|
| Reference =<ref>{{Dead link|date=July 2019 |bot=InternetArchiveBot |fix-attempted=yes }}</ref> |
|
| Name = Diphenylmethanol |
|
|
| ImageFile_Ref = {{chemboximage|correct|??}} |
|
| Name = Diphenylmethanol |
|
|
| ImageFile_Ref = {{chemboximage|correct|??}} |
|
| ImageFile = Diphenylmethanol.png |
|
| ImageFile = Diphenylmethanol.png |
|
| ImageSize = 200px |
|
| ImageSize = |
|
| ImageName = Diphenylmethanol |
|
| ImageName = Diphenylmethanol |
|
| ImageFile1 = Diphenylmethanol-3D-balls.png |
|
| ImageFile1 = Diphenylmethanol-from-xtal-3D-bs-17.png |
|
| IUPACName = Diphenylmethanol |
|
| PIN = Diphenylmethanol |
|
| OtherNames = Benzhydrol<br/>Diphenylcarbinol<br/>Hydroxydiphenylmethane |
|
| OtherNames = Benzhydrol<br/>Diphenylcarbinol<br/>Hydroxydiphenylmethane |
|
| Section1 = {{Chembox Identifiers |
|
|Section1={{Chembox Identifiers |
|
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
|
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
|
| ChemSpiderID = 6770 |
|
| ChemSpiderID = 6770 |
|
|
| ChEBI = 156087 |
|
|
| EC_number = 202-033-8 |
|
| PubChem = 7037 |
|
| PubChem = 7037 |
|
| InChI = 1/C13H12O/c14-13(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,13-14H |
|
| InChI = 1/C13H12O/c14-13(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,13-14H |
| Line 23: |
Line 26: |
|
| CASNo_Ref = {{cascite|correct|CAS}} |
|
| CASNo_Ref = {{cascite|correct|CAS}} |
|
| CASNo = 91-01-0 |
|
| CASNo = 91-01-0 |
|
|
| UNII_Ref = {{fdacite|correct|FDA}} |
|
|
| UNII = S4HQ1H8OWD |
|
}} |
|
}} |
|
| Section2 = {{Chembox Properties |
|
|Section2={{Chembox Properties |
|
| C=13|H=12|O=1 |
|
| C=13 | H=12 | O=1 |
|
| Appearance = White crystals |
|
| Appearance = White crystals |
|
| Density = |
|
| Density = 1.103 g/cm<sup>3</sup> |
|
| Solubility = 0.5 g/L (20°C) |
|
| Solubility = 0.5 g/L (20 °C) |
|
|
| MeltingPtC = 69 |
|
| MeltingPt = 65-67 °C |
|
|
|
| MeltingPt_notes = |
|
| BoilingPt = 297-298 °C |
|
|
| pKa = |
|
| BoilingPtC = 298 |
|
| Viscosity = |
|
| pKa = |
|
|
| Viscosity = |
|
|
| MagSus = -119.1·10<sup>−6</sup> cm<sup>3</sup>/mol |
|
}} |
|
}} |
|
| Section7 = {{Chembox Hazards |
|
|Section7={{Chembox Hazards |
|
| ExternalMSDS = |
|
| ExternalSDS = |
|
|
| Hazards_ref=<ref>{{cite web |title=Diphenylmethanol |url=https://pubchem.ncbi.nlm.nih.gov/compound/7037#section=Safety-and-Hazards |website=pubchem.ncbi.nlm.nih.gov |language=en}}</ref> |
|
| EUClass = |
|
|
|
| GHSPictograms = {{GHS07}} |
|
| FlashPt = |
|
|
|
| GHSSignalWord = Warning |
|
| RPhrases = {{R36}} {{R37}} {{R38}} |
|
|
|
| HPhrases = {{H-phrases|315|319|335}} |
|
| SPhrases = {{S26}} {{S27}} {{S28}} {{S29}} {{S30}} {{S33}} {{S35}} {{S36}} |
|
|
|
| PPhrases = {{P-phrases|261|264|271|280|302+352|304+340|305+351+338|312|321|332+313|337+313|362|403+233|405|501}} |
|
}} |
|
}} |
|
| Section8 = {{Chembox Related |
|
|Section8={{Chembox Related |
|
| OtherCpds = ]}} |
|
| OtherCompounds = ]}} |
|
}} |
|
}} |
|
|
|
|
|
'''Diphenylmethanol''', (C<sub>6</sub>H<sub>5</sub>)<sub>2</sub>CHOH, is a secondary ] with a ] of 184.23 g/mol. It has a melting point of between 65 and 67 °C and a boiling point of between 297 and 298 °C. It has uses in ] and ] manufacture. |
|
'''Diphenylmethanol''' is the ] with the formula (C<sub>6</sub>H<sub>5</sub>)<sub>2</sub>CHOH. Also known as '''benzhydrol''', it is a white solid and the parent member of a large class of diaryl alcohols. |
|
⚫ |
==Preparation== |
|
⚫ |
Diphenylmethanol may be prepared by a ] between ] and ]{{cn|date=July 2022}}. An alternative method involves reducing ] with ] or with ] dust or with sodium amalgam and water.<ref>{{OrgSynth | first1= F. Y.|last1=Wiselogle |first2= H.|last2=Sonneborn, III | title = Benzohydrol | year = 1928| doi= 10.15227/orgsyn.008.0024| volume = 8 | page= 23}}</ref> |
|
|
|
|
|
|
== Uses and safety == |
| ⚫ |
Diphenylmethanol is an irritant to the eyes, skin and respiratory system. |
|
|
|
It has uses in ] and ] manufacture. In perfumery it is used as a ]. In pharmaceutical manufacture it is used in the ] of ] / ] agents and ] agents . It is used in the synthesis of ]<ref>{{Cite patent|country=EP|number=1583739|title=Method for preparing methyl 2-diphenylmethylsulfinylacetate|pubdate=2005-10-12 |
|
|
|assign=Organisation de Synthese Mondi |
|
|
|inventor1-last=Rose |inventor1-first=Sebastien |
|
|
|inventor2-last=Klein |inventor2-first=Dominique |
|
|
}}</ref> and the ] group is present in the structure of many histamine ]s like ]. Benzhydrol is also used in the production of ] as well as other organic compounds and as a terminating group in ]s. |
|
|
|
|
|
⚫ |
Diphenylmethanol is an ] to the eyes, skin and respiratory system. |
| ⚫ |
==Preparation== |
|
| ⚫ |
Diphenylmethanol may be prepared by a Grignard reaction between ] and ], or by reducing ], with ] or with ] dust.<ref>{{OrgSynth | author = F. Y. Wiselogle and H. Sonneborn, III | title = Benzohydrol | year = 1941 | prep = cv1p0090 | collvol = 1 | collvolpages = 90}}</ref> |
|
|
|
|
|
|
==References== |
|
==References== |
|
<references/> |
|
<references/> |
|
|
|
|
|
] |
|
] |
|
] |
|
] |
|
|
|
|
] |
|
|
] |
|