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Revision as of 09:31, 24 October 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'StdInChI', 'StdInChIKey').← Previous edit		Latest revision as of 00:52, 15 May 2024 edit undoGraeme Bartlett (talk | contribs)Administrators249,514 editsm nav template
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	{{chembox		{{chembox
	| Verifiedfields = changed		| Verifiedfields = changed
			| Watchedfields = changed
	| verifiedrevid = 430359627
			| verifiedrevid = 457118728
	|ImageFile = Disodium hydrogen phosphate.png
			| ImageFile = Disodium hydrogen phosphate.png
	| ImageSize = 150px		| ImageSize = 150px
	| IUPACName = Sodium hydrogen phosphate		| ImageAlt = Structural formula of disodium phosphate
	| OtherNames = Disodium hydrogen orthophosphate<br/>Sodium hydrogen phosphate<br/>Sodium phosphate dibasic		| ImageFile1 = Disodium phosphate 3D spacefill.png
			| ImageSize1 = 250
			| ImageAlt1 = Ball-and-stick model of the component ions of disodium phosphate
			| ImageCaption1 = {{legend|purple|], Na}}{{legend|orange|], P}}{{legend|red|], O}}{{legend|white|], H}}
			| ImageFile2 = Hydrogenfosforečnan sodný dodekahydrát.jpg
			| IUPACName = Disodium hydrogen phosphate
			| OtherNames = {{ubl|Acetest|Dibasic sodium phosphate|Disodium hydrogen orthophosphate|Disodium hydrogen phosphate|Disodium phosphate|Sodium phosphate dibasic}}
			| SystematicName =
	| Section1 = {{Chembox Identifiers		| Section1 = {{Chembox Identifiers
	| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}		| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
	| ChemSpiderID = 22625		| ChemSpiderID = 22625
	| UNII_Ref = {{fdacite|correct|FDA}}		| UNII_Ref = {{fdacite|correct|FDA}}
	| UNII = 22ADO53M6F		| UNII = 22ADO53M6F
			| UNII2_Ref = {{fdacite|correct|FDA}}
			| UNII2 = 94255I6E2T
			| UNII2_Comment = (dihydrate)
			| UNII3_Ref = {{fdacite|correct|FDA}}
			| UNII3 = 70WT22SF4B
			| UNII3_Comment = (heptahydrate)
			| UNII4_Ref = {{fdacite|correct|FDA}}
			| UNII4 = E1W4N241FO
			| UNII4_Comment = (dodecahydrate)
	| InChI = 1/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-3		| InChI = 1/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-3
	| ChEMBL_Ref = {{ebicite|changed|EBI}}		| ChEMBL_Ref = {{ebicite|correct|EBI}}
	| ChEMBL = 1060		| ChEMBL = 1060
	| ChEBI_Ref = {{ebicite|changed|EBI}}		| ChEBI_Ref = {{ebicite|correct|EBI}}
	| ChEBI = 34683		| ChEBI = 34683
	| SMILES = ..P()()=O		| SMILES = OP(=O)()..
	| InChIKey = BNIILDVGGAEEIG-DFZHHIFOAK		| InChIKey = BNIILDVGGAEEIG-DFZHHIFOAK
	| StdInChI_Ref = {{stdinchicite|correct|chemspider}}		| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
	| StdInChIKey = BNIILDVGGAEEIG-UHFFFAOYSA-L		| StdInChIKey = BNIILDVGGAEEIG-UHFFFAOYSA-K
	| StdInChI = 1S/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-2		| StdInChI = 1S/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-3
	| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}		| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
	| CASNo = 7558-79-4		| CASNo = 7558-79-4
	| CASNo_Ref = {{cascite|correct|CAS}}		| CASNo_Ref = {{cascite|correct|CAS}}
			| CASNo2_Ref = {{cascite|correct|CAS}}
	| CASOther = <br/>10028-24-7 (dihydrate)<br/>7782-85-6 (heptahydrate)<br/>10039-32-4 (dodecahydrate)
	| PubChem =		| CASNo2 = 10028-24-7
			| CASNo2_Comment = (dihydrate)
	| EINECS = 231-448-7
			| CASNo3_Ref = {{cascite|correct|CAS}}
	| RTECS = WC4500000
			| CASNo3 = 7782-85-6
	}}
			| CASNo3_Comment = (heptahydrate)
			| CASNo4_Ref = {{cascite|correct|CAS}}
			| CASNo4 = 10039-32-4
			| CASNo4_Comment = (dodecahydrate)
			| PubChem = 24203
			| EINECS = 231-448-7
			| RTECS = WC4500000
			}}
	| Section2 = {{Chembox Properties		| Section2 = {{Chembox Properties
	| Formula = Na<sub>2</sub>HPO<sub>4</sub>		| Formula = {{chem2|Na2HPO4}}
	| MolarMass = 141.96 g/mol		| MolarMass = {{ubl|141.96 g/mol (anhydrous)|177.99 g/mol (dihydrate)|268.07 g/mol (heptahydrate)}}
	| Appearance = White crystalline solid		| Appearance = White crystalline solid
			| RefractIndex = 1.35644 to 1.35717 at 20°C
	| Density = 0.5–1.2 g/cm<sup>3</sup>
			| Odor = Odorless
	| MeltingPt = 250 ºC decomp.
	| Solubility = 7.7 g/100 ml (20 ºC)		| Density = 1.7 g/cm<sup>3</sup>
			| MeltingPtC = 250
	}}
			| MeltingPt_notes = Decomposes
			| Solubility = 7.7 g/(100 ml) (20 °C)<br>11.8 g/(100 ml) (25 °C, heptahydrate)
			| SolubleOther = Insoluble in ]
			| pKa = 12.35
			| LogP = −5.8
			| MagSus = −56.6·10<sup>−6</sup> cm<sup>3</sup>/mol
			}}
			| Section3 =
			| Section4 =
			| Section5 =
			| Section6 =
	| Section7 = {{Chembox Hazards		| Section7 = {{Chembox Hazards
	| ExternalMSDS =		| ExternalSDS =
	| EUIndex = Not listed		| NFPA-H = 1
	| NFPA-H = 1		| NFPA-F = 0
	| NFPA-F = 0		| NFPA-R = 0
	| NFPA-R = 0		| MainHazards = Irritant
			| FlashPt = Non-flammable
	| MainHazards = Irritant
			| LD50 = 17000 mg/kg (rat, oral)
	| FlashPt = Non-flammable
	}}		}}
	| Section8 = {{Chembox Related		| Section8 = {{Chembox Related
	| OtherAnions = ]		| OtherAnions = ]
	| OtherCations = ]<br/>]		| OtherCations = ]<br/>]
	| OtherCpds = ]<br/>]		| OtherCompounds = ]<br/>]
	}}		}}
	}}		}}
	'''Disodium hydrogen phosphate''' (Na<sub>2</sub>HPO<sub>4</sub>) is a ] ] of ]. It is a white powder that is highly ] and water soluble.<ref> </ref> It is therefore used commercially as an anti-caking additive in powdered products. It is also known as disodium hydrogen orthophosphate, sodium hydrogen phosphate or sodium phosphate dibasic. It is commercially available in both the hydrated and anhydrous forms.<ref> </ref> pH of disodium hydrogen phosphate water solution is between 8.0 and 11.0.		'''Disodium phosphate''' ('''DSP'''), or '''disodium hydrogen phosphate''', or '''sodium phosphate dibasic''', is an ] with the ] {{chem2|Na2HPO4|auto=1}}. It is one of several ]. The ] is known in ] form as well as ] {{chem2|Na2HPO4*''n''H2O}}, where ''n'' is 2, 7, 8, and 12. All are water-soluble white powders. The anhydrous salt is ].<ref>{{Cite web |url=http://www.ffcr.or.jp/zaidan/FFCRHOME.nsf/7bd44c20b0dc562649256502001b65e9/916cae3da5a8a11b49256f320018877f/$FILE/D121.pdf |title=Physical data (pdf) |access-date=2007-03-06 |archive-url=https://web.archive.org/web/20110717102830/http://www.ffcr.or.jp/zaidan/FFCRHOME.nsf/7bd44c20b0dc562649256502001b65e9/916cae3da5a8a11b49256f320018877f/$FILE/D121.pdf |archive-date=2011-07-17 |url-status=dead}}</ref>
			The ] of disodium hydrogen phosphate water solution is between 8.0 and 11.0, meaning it is moderately ]:
	==Preparation==
			:{{chem2|HPO4(2−) + H2O ⇌ H2PO4− + OH−}}
	It may be formed by reaction of stoichiometric quantities of ] and ]:
	:2 NaOH + H<sub>3</sub>PO<sub>4</sub> → Na<sub>2</sub>HPO<sub>4</sub> + 2 H<sub>2</sub>O
			==Production and reactions==
	== Other uses ==
			It can be generated by neutralization of ] with ]:
	*Disodium phosphate is used in ] to quicken cook time, as described on the ingredients panel of the product package.
			:{{chem2|H3PO4 + 2 NaOH → Na2HPO4 + 2 H2O}}
	*Disodium phosphate is used in conjunction with ] in many steam-boiler applications. It supplies the inventory of free phosphates to retard calcium scale formation.
	*Monobasic and dibasic sodium phosphate is used as a to treat constipation or to clean the bowel before a colonoscopy.
			Industrially It is prepared in a two-step process by treating ] with ], which precipitates ]:<ref name=Ullmann>Klaus Schrödter, Gerhard Bettermann, Thomas Staffel, Friedrich Wahl, Thomas Klein, Thomas Hofmann "Phosphoric Acid and Phosphates" in ''Ullmann’s Encyclopedia of Industrial Chemistry'' 2008, Wiley-VCH, Weinheim. {{doi|10.1002/14356007.a19_465.pub3}}</ref>
	== References ==
			:{{chem2|CaHPO4 + NaHSO4 → NaH2PO4 + CaSO4}}
			In the second step, the resulting solution of monosodium phosphate is partially neutralized:
			:{{chem2|NaH2PO4 + NaOH → Na2HPO4 + H2O}}
			==Uses==
			It is used in conjunction with ] in foods and water softening treatment. In foods, it is used to adjust pH. Its presence prevents coagulation in the preparation of condensed milk. Similarly, it is used as an anti-caking additive in powdered products.<ref>{{Cite web |url=http://www.sciencelab.com/msds.php?msdsId=9925023 |title=MSDS |access-date=2011-09-26 |archive-url=https://web.archive.org/web/20171028050920/http://www.sciencelab.com/msds.php?msdsId=9925023 |archive-date=2017-10-28 |url-status=dead}}</ref> It is used in desserts and puddings, e.g. ] to quicken cook time, and Jell-O ] for thickening. In water treatment, it retards ].{{Citation needed|date=September 2021}} It is also found in some detergents and cleaning agents.<ref name=Ullmann/>
			Heating solid disodium phosphate gives the useful compound ]:{{citation needed|date=July 2016}}
			:{{chem2|2 Na2HPO4 → Na4P2O7 + H2O}}
			=== Laxative ===
			Monobasic and dibasic sodium phosphate are used as a ] to treat ] or to clean the bowel before a ].<ref>{{Cite web | url = http://wishardhealth.kramesonline.com/Medications/26,1558 | title = Sodium Phosphate, Dibasic, Sodium Phosphate, Monobasic Oral solution | publisher = Krames Patient Education | access-date = 2009-10-29 | archive-url = https://archive.today/20130128005243/http://wishardhealth.kramesonline.com/Medications/26,1558 | archive-date = 2013-01-28 | url-status = dead}}</ref>
			==References==
	{{reflist}}		{{reflist}}
			==External links==
			*{{Commonscatinline}} solubility in Prophylaxis alcohol
	{{Sodium compounds}}		{{Sodium compounds}}
			{{Phosphates}}
	]		]
	]		]
			]
	{{inorganic-compound-stub}}
	]
	]
	]
	]
	]
	]
	]