| Revision as of 10:40, 17 November 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{drugbox}} taken from revid 456757461 of page Dyclonine for the Chem/Drugbox validation project (updated: 'DrugBank', 'ChEMBL'). |
Latest revision as of 00:33, 18 February 2024 edit InternetArchiveBot (talk | contribs)Bots, Pending changes reviewers5,382,321 edits Rescuing 1 sources and tagging 0 as dead.) #IABot (v2.0.9.5 |
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{{short description|Anesthetic}} |
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{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid of page ] with values updated to verified values.}} |
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{{Drugbox |
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{{Drugbox |
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| Verifiedfields = changed |
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| Verifiedfields = changed |
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| verifiedrevid = 406008143 |
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| verifiedrevid = 461091735 |
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| IUPAC_name = 1-(4-butoxyphenyl)-3-(1-piperidyl)propan-1-one |
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| IUPAC_name = 1-(4-butoxyphenyl)-3-(1-piperidyl)propan-1-one |
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| image = Dyclonine.png |
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| image = Dyclonine Structural Formula V.1.svg |
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<!--Clinical data--> |
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<!--Clinical data--> |
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| tradename = Sucrets |
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| tradename = Sucrets |
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| Drugs.com = {{drugs.com|monograph|dyclonine-hydrochloride}} |
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| Drugs.com = {{drugs.com|monograph|dyclonine-hydrochloride}} |
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| pregnancy_category = |
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| pregnancy_US = C |
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| legal_status = |
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| legal_US = OTC |
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| routes_of_administration = |
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| routes_of_administration = Lozenge |
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<!--Pharmacokinetic data--> |
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<!--Pharmacokinetic data--> |
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| bioavailability = |
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| bioavailability = |
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| protein_bound = |
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| protein_bound = |
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| metabolism = |
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| metabolism = |
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| elimination_half-life = |
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| elimination_half-life = |
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<!--Identifiers--> |
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<!--Identifiers--> |
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| IUPHAR_ligand = 7173 |
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| CASNo_Ref = {{cascite|correct|CAS}} |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 586-60-7 |
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| CAS_number = 586-60-7 |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| KEGG = D07881 |
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| KEGG = D07881 |
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| ChEBI_Ref = {{ebicite|changed|EBI}} |
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| ChEBI_Ref = {{ebicite|correct|EBI}} |
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| ChEBI = 4724 |
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| ChEBI = 4724 |
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| ChEMBL_Ref = {{ebicite|changed|EBI}} |
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| ChEMBL_Ref = {{ebicite|changed|EBI}} |
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| ChEMBL = <!-- blanked - oldvalue: 1201217 --> |
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| ChEMBL = 1201217 |
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<!--Chemical data--> |
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| C=18 | H=27 | N=1 | O=2 |
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| C=18 | H=27 | N=1 | O=2 |
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| molecular_weight = 289.413 g/mol |
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| smiles = O=C(c1ccc(OCCCC)cc1)CCN2CCCCC2 |
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| smiles = O=C(c1ccc(OCCCC)cc1)CCN2CCCCC2 |
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| InChI = 1/C18H27NO2/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19/h7-10H,2-6,11-15H2,1H3 |
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| InChIKey = BZEWSEKUUPWQDQ-UHFFFAOYAN |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C18H27NO2/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19/h7-10H,2-6,11-15H2,1H3 |
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| StdInChI = 1S/C18H27NO2/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19/h7-10H,2-6,11-15H2,1H3 |
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| StdInChIKey = BZEWSEKUUPWQDQ-UHFFFAOYSA-N |
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| StdInChIKey = BZEWSEKUUPWQDQ-UHFFFAOYSA-N |
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}} |
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}} |
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'''Dyclonine''' ('''Dyclocaine''') is an oral ] that is the active ingredient of '''Sucrets''', an ] ].<ref>{{cite encyclopedia |author=Janice Jorgensen |encyclopedia= Encyclopedia of Consumer Brands: Personal products |title=Sucrets |url=https://books.google.com/books?id=cNQbAAAAIAAJ&pg=PA525 |isbn= 9781558623378|year=1994 |publisher=] | access-date=2011-09-24 }}</ref> It is also found in some varieties of the ] ] spray. It is a local anesthetic, used topically as the hydrochloride salt.<ref>{{cite journal | vauthors = Gargiulo AV, Burns GM, Huck CP | title = Dyclonine hydrochloride--a topical agent for managing pain | journal = Illinois Dental Journal | volume = 61 | issue = 4 | pages = 303–4 | year = 1992 | pmid = 1286862 }}</ref> |
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==History== |
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The product Sucrets was introduced in ], by ] in 1932.<ref name=tin/> |
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In 1966 the ] ordered ] to discontinue the ]s of germ-killing and pain-relieving properties for its Sucrets and Children's Sucrets throat lozenges.<ref>{{cite news |title=F.T.C. Bids Merck Halt Claims That Lozenges Will Kill Germs |url=https://select.nytimes.com/gst/abstract.html?res=FA0C15F63F58107B93C2AB178FD85F428685F9 |agency=] |work=] |date=April 19, 1966 |access-date=2011-09-24 }}</ref> In 1977, it was acquired by ], later merging with ] in 1989 to form SmithKline Beecham. By 1994 the brand switched from a metal container to a ].<ref name=tin>{{cite news |title=The Sucrets tin joins the age of plastics |url=https://pqasb.pqarchiver.com/USAToday/access/55245690.html?dids=55245690:55245690&FMT=ABS&FMTS=ABS:FT&type=current&date=Jul+19%2C+1994&author=Michelle+Healy&pub=USA+TODAY+(pre-1997+Fulltext)&desc=The+Sucrets+tin+joins+the+age+of+plastics&pqatl=google |newspaper=] |date=July 19, 1994 |access-date=2011-09-24 |archive-date=2017-08-22 |archive-url=https://web.archive.org/web/20170822221441/http://www.pqarchiver.com/titles?dids=55245690:55245690&FMT=ABS&FMTS=ABS:FT&type=current&date=Jul+19%2C+1994&author=Michelle+Healy&pub=USA+TODAY+(pre-1997+Fulltext)&desc=The+Sucrets+tin+joins+the+age+of+plastics&pqatl=google |url-status=dead }}</ref> |
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SmithKline Beecham, after announcing a merger with GlaxoWellcome to form ], sold the brand in 2000 to ]. In 2011, Sucrets reintroduced their product back into the familiar tin due to popular demand and nostalgia. |
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== See also == |
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* ] |
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== References == |
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{{reflist}} |
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== External links == |
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* |
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{{Throat preparations}} |
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] |
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] |
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] |
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] |
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] |
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{{respiratory-system-drug-stub}} |
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{{nervous-system-drug-stub}} |