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{{Short description|Chemical compound}} |
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{{drugbox |
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{{Drugbox |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| Verifiedfields = changed |
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| UNII = 776S0UP252 |
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| Watchedfields = changed |
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| verifiedrevid = 437158174 |
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| verifiedrevid = 444165382 |
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| drug_name = Flutrimazole |
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| IUPAC_name = (''RS'')-1--1''H''-imidazole |
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| IUPAC_name = (''RS'')-1--1''H''-imidazole |
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| image = Flutrimazole.png |
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| image = Flutrimazole.svg |
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| width = 180 |
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| imagename = 1 : 1 mixture (racemate) |
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| chirality = ] |
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| width = 200px |
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<!--Clinical data--> |
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| tradename = |
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| Drugs.com = {{drugs.com|international|flutrimazole}} |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category = |
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
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| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_status = |
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| routes_of_administration = |
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<!--Pharmacokinetic data--> |
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| bioavailability = |
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| protein_bound = |
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| metabolism = |
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| elimination_half-life = |
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| excretion = |
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<!--Identifiers--> |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 119006-77-8 |
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| ATC_prefix = D01 |
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| ATC_suffix = AC16 |
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| ATC_supplemental = {{ATC|G01|AF18}} |
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| PubChem = 3401 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 3284 |
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| ChemSpiderID = 3284 |
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| ChEMBL_Ref = {{ebicite|changed|EBI}} |
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| InChI = 1/C22H16F2N2/c23-19-12-10-18(11-13-19)22(26-15-14-25-16-26,17-6-2-1-3-7-17)20-8-4-5-9-21(20)24/h1-16H |
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| ChEMBL = 2107430 |
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| InChIKey = QHMWCHQXCUNUAK-UHFFFAOYAR |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = 776S0UP252 |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| KEGG = D07193 |
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| ChEBI_Ref = {{ebicite|changed|EBI}} |
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| ChEBI = 82864 |
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<!--Chemical data--> |
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| C=22 | H=16 | F=2 | N=2 |
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| smiles = Fc1ccc(cc1)C(c2c(F)cccc2)(c3ccccc3)n4ccnc4 |
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| smiles = Fc1ccc(cc1)C(c2c(F)cccc2)(c3ccccc3)n4ccnc4 |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = QHMWCHQXCUNUAK-UHFFFAOYSA-N |
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| StdInChIKey = QHMWCHQXCUNUAK-UHFFFAOYSA-N |
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| CAS_number = 119006-77-8 |
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| ATC_prefix = G01 |
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| ATC_suffix = AF18 |
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| PubChem = 3401 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| KEGG = D07193 |
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| C=22|H=16|F=2|N=2 |
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| molecular_weight = 346.373 g/mol |
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| bioavailability = |
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| protein_bound = |
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| metabolism = |
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| elimination_half-life = |
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| excretion = |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category= |
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
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| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_status = |
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| routes_of_administration = |
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}} |
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}} |
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'''Flutrimazole''' is a wide spectrum ] drug. It is used for the topical treatment of superficial ] of the ]. Flutrimazole is an ] derivative. It interferes with the synthesis of ] by inhibiting the activity of the ] ]. |
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'''Flutrimazole''' is a wide-spectrum ] drug. It is used for the topical treatment of superficial ] of the ]. Flutrimazole is an ] derivative. Its antifungal activity has been demonstrated in ''in vivo'' and ''in vitro'' studies to be comparable to that of ] and higher than ].<ref>{{cite journal | vauthors = Alomar A, Videla S, Delgadillo J, Gich I, Izquierdo I, Forn J | title = Flutrimazole 1% dermal cream in the treatment of dermatomycoses: a multicentre, double-blind, randomized, comparative clinical trial with bifonazole 1% cream. Efficacy of flutrimazole 1% dermal cream in dermatomycoses. Catalan Flutrimazole Study Group | journal = Dermatology | volume = 190 | issue = 4 | pages = 295–300 | date = 1995 | pmid = 7655109 | doi = 10.1159/000246720 }}</ref> |
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==Mechanism of action== |
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It interferes with the synthesis of ] by inhibiting the activity of the ] ].{{cn|date=December 2022}} |
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== See also == |
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* ] |
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== References == |
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== References == |
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The Merck Index, 12th Edition. 4247 |
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{{refbegin}} |
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{{reflist}} |
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* The Merck Index, 12th Edition. 4247 |
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{{refend}} |
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{{Antifungals}} |
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{{Gynecological anti-infectives and antiseptics}} |
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{{Gynecological anti-infectives and antiseptics}} |
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] |
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{{antiinfective-drug-stub}} |
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{{antiinfective-drug-stub}} |
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{{genito-urinary-drug-stub}} |
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{{genito-urinary-drug-stub}} |
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] |
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