Misplaced Pages

GM2 (ganglioside): Difference between revisions

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Browse history interactively
Page 1
Page 2
← Previous editContent deleted Content addedVisualWikitext
Revision as of 12:57, 29 October 2011 editThe chemistds (talk | contribs)Extended confirmed users5,761 edits added CSID, (Std)InChI & (Std)InChIKey← Previous edit Latest revision as of 17:41, 5 July 2023 edit undoHeadbomb (talk | contribs)Edit filter managers, Autopatrolled, Extended confirmed users, Page movers, File movers, New page reviewers, Pending changes reviewers, Rollbackers, Template editors453,872 edits ce 
(20 intermediate revisions by 16 users not shown)
Line 1: Line 1:
{{Chembox {{Chembox
| Name = GM2
| Verifiedfields = changed | Verifiedfields = changed
⚫ | verifiedrevid = 458296360
| Watchedfields = changed
⚫ | verifiedrevid = 428736070
| ImageFile = GM2 ganglioside.png | ImageFile = GM2 ganglioside.png
| ImageSize = 250px | ImageSize = 250px
| ImageAlt = | ImageAlt =
| IUPACName = (2''S'',3''R'',4''E'')-3-Hydroxy-2-(octadecanoylamino)octadec-4-en-1-yl 2-acetamido-2-deoxy-β-<small>D</small>-galactopyranosyl-(1→4)--β-<small>D</small>-galactopyranosyl-(1→4)-β-<small>D</small>-glucopyranoside | IUPACName = (2''S'',3''R'',4''E'')-3-Hydroxy-2-octadecanamidooctadec-4-en-1-yl (5-acetamido-3,5-dideoxy-<small>D</small>-''glycero''-α-<small>D</small>-''galacto''-non-2-ulopyranosylonic acid)-(2→3)--β-<small>D</small>-galactopyranosyl-(1→4)-β-<small>D</small>-glucopyranoside
| SystematicName = (2''S'',4''S'',5''R'',6''R'')-5-Acetamido-2-{oxy}-6-{oxy}oxan-3-yl]oxy}-5-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-6-oxane-2-carboxylate
| IUPACName_hidden=yes
| OtherNames = Ganglioside GM2; Tay-Sachs ganglioside; β-<small>D</small>-GalNAc-(1→4)--β-<small>D</small>-Gal-(1→4)-β-<small>D</small>-Glc-(1↔1)-''N''-octadecanoylsphingosine | OtherNames = Ganglioside GM2; Tay–Sachs ganglioside;<br/>β-<small>D</small>-GalNAc-(1→4)--β-<small>D</small>-Gal-(1→4)-β-<small>D</small>-Glc-(1↔1)-''N''-octadecanoylsphingosine
| Section1 = {{Chembox Identifiers | Section1 = {{Chembox Identifiers
| CASNo_Ref = {{cascite|correct|CAS}} | CASNo_Ref = {{cascite|correct|CAS}}
| CASNo = 19600-01-2 | CASNo = 19600-01-2
| UNII_Ref = {{fdacite|correct|FDA}}
⚫ | PubChem =
| UNII = X8HRQ6G9HF
⚫ | ChemSpiderID = 26286730
⚫ | PubChem = 71308211
⚫ | SMILES = CCCCCCCCCCCCCCCCCC(=O)N(CO1((((O1)CO)O2((((O2)CO)O3((((O3)CO)O)O)NC(=O)C)OC4(C(((O4)((CO)O)O)NC(=O)C)O)C(=O)O)O)O)O)(/C=C/CCCCCCCCCCCCC)O
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
⚫ | InChI = 1/C68H123N3O26/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-51(81)71-44(45(78)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-90-65-58(86)57(85)60(49(38-74)93-65)95-66-59(87)63(61(50(39-75)94-66)96-64-53(70-43(4)77)56(84)55(83)48(37-73)92-64)91-41-68(67(88)89)35-46(79)52(69-42(3)76)62(97-68)54(82)47(80)36-72/h31,33,44-50,52-66,72-75,78-80,82-87H,5-30,32,34-41H2,1-4H3,(H,69,76)(H,70,77)(H,71,81)(H,88,89)/b33-31+/t44-,45+,46-,47+,48+,49+,50+,52+,53+,54+,55-,56+,57+,58+,59+,60+,61-,62+,63+,64-,65-,66-,68-/m1/s1
⚫ | ChemSpiderID = 26286730
⚫ | InChIKey = USMMPBVNWHAJBE-YMEOXFOQBT
⚫ | SMILES = CCCCCCCCCCCCCCCCCC(=O)N(CO1((((O1)CO)O2((((O2)CO)O3((((O3)CO)O)O)NC(=O)C)OC4(C(((O4)((CO)O)O)NC(=O)C)O)C(=O)O)O)O)O)(/C=C/CCCCCCCCCCCCC)O
⚫ | StdInChI = 1S/C68H123N3O26/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-51(81)71-44(45(78)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-90-65-58(86)57(85)60(49(38-74)93-65)95-66-59(87)63(61(50(39-75)94-66)96-64-53(70-43(4)77)56(84)55(83)48(37-73)92-64)91-41-68(67(88)89)35-46(79)52(69-42(3)76)62(97-68)54(82)47(80)36-72/h31,33,44-50,52-66,72-75,78-80,82-87H,5-30,32,34-41H2,1-4H3,(H,69,76)(H,70,77)(H,71,81)(H,88,89)/b33-31+/t44-,45+,46-,47+,48+,49+,50+,52+,53+,54+,55-,56+,57+,58+,59+,60+,61-,62+,63+,64-,65-,66-,68-/m1/s1
⚫ | InChI = 1/C68H123N3O26/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-51(81)71-44(45(78)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-90-65-58(86)57(85)60(49(38-74)93-65)95-66-59(87)63(61(50(39-75)94-66)96-64-53(70-43(4)77)56(84)55(83)48(37-73)92-64)91-41-68(67(88)89)35-46(79)52(69-42(3)76)62(97-68)54(82)47(80)36-72/h31,33,44-50,52-66,72-75,78-80,82-87H,5-30,32,34-41H2,1-4H3,(H,69,76)(H,70,77)(H,71,81)(H,88,89)/b33-31+/t44-,45+,46-,47+,48+,49+,50+,52+,53+,54+,55-,56+,57+,58+,59+,60+,61-,62+,63+,64-,65-,66-,68-/m1/s1
⚫ | StdInChIKey = USMMPBVNWHAJBE-YMEOXFOQSA-N
⚫ | InChIKey = USMMPBVNWHAJBE-YMEOXFOQBT
⚫ | ChEBI_Ref = {{ebicite|changed|EBI}}
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
⚫ | ChEBI = 60327}}
⚫ | StdInChI = 1S/C68H123N3O26/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-51(81)71-44(45(78)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-90-65-58(86)57(85)60(49(38-74)93-65)95-66-59(87)63(61(50(39-75)94-66)96-64-53(70-43(4)77)56(84)55(83)48(37-73)92-64)91-41-68(67(88)89)35-46(79)52(69-42(3)76)62(97-68)54(82)47(80)36-72/h31,33,44-50,52-66,72-75,78-80,82-87H,5-30,32,34-41H2,1-4H3,(H,69,76)(H,70,77)(H,71,81)(H,88,89)/b33-31+/t44-,45+,46-,47+,48+,49+,50+,52+,53+,54+,55-,56+,57+,58+,59+,60+,61-,62+,63+,64-,65-,66-,68-/m1/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
⚫ | StdInChIKey = USMMPBVNWHAJBE-YMEOXFOQSA-N
⚫ | ChEBI_Ref = {{ebicite|changed|EBI}}
⚫ | ChEBI = 60327
}}
| Section2 = {{Chembox Properties | Section2 = {{Chembox Properties
| C=67|H=121|N=3|O=26 | C=67|H=121|N=3|O=26
| Appearance = | Appearance =
| Density = | Density =
| MeltingPt = | MeltingPt =
| BoilingPt = | BoilingPt =
| Solubility = }} | Solubility =
}}
| Section3 = {{Chembox Hazards | Section3 = {{Chembox Hazards
| MainHazards = | MainHazards =
| FlashPt = | FlashPt =
| AutoignitionPt =
| Autoignition = }}
}}
}} }}


'''GM2''' is a type of ]. It is associated with ] such as ].<ref name="pmid18425478">{{cite journal |author=Guetta E, Peleg L |title=Rapid Detection of Fetal Mendalian Disorders: Tay-Sachs Disease |journal=] |volume=444 |issue= |pages=147–59 |year=2008 |pmid=18425478 |doi=10.1007/978-1-59745-066-9_11}}</ref> In ], '''GM2''' is a type of ]. G refers to ], the M is for monosialic (as in it has one ]), and 2 refers to the fact that it was the second monosialic ganglioside discovered. It is associated with ] such as ].<ref name="pmid18425478">{{cite book |vauthors=Guetta E, Peleg L |title=Rapid Detection of Fetal Mendalian Disorders: Tay–Sachs Disease |series=Methods in Molecular Biology |volume=444 |pages=147–59 |year=2008 |pmid=18425478 |doi=10.1007/978-1-59745-066-9_11|isbn=978-1-58829-803-4 }}</ref>


==See also== ==See also==
Line 42: Line 50:
<gallery> <gallery>
Image:Sphingolipidoses.svg|Sphingolipidoses Image:Sphingolipidoses.svg|Sphingolipidoses
Image:Structure of GM1, GM2, GM3.png|Structures of GM1, GM2, GM3 gangliosides
</gallery> </gallery>


Line 50: Line 59:
* {{MeshName|Ganglioside+GM2}} * {{MeshName|Ganglioside+GM2}}


{{biochem-stub}}
{{Sphingolipids}} {{Sphingolipids}}