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Revision as of 09:33, 6 December 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{drugbox}} taken from revid 464210156 of page Insulin_detemir for the Chem/Drugbox validation project (updated: 'UNII', 'CAS_number').  Latest revision as of 00:29, 12 November 2024 edit Citation bot (talk | contribs)Bots5,391,853 edits Added date. | Use this bot. Report bugs. | Suggested by Whywhenwhohow | #UCB_webform 276/617 
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{{Short description|Long-acting man-made insulin}}
{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid of page ] with values updated to verified values.}}
{{Use dmy dates|date=October 2022}}
{{Drugbox {{Drugbox
| Verifiedfields = changed | Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 461935751 | verifiedrevid = 464363066
| IUPAC_name =
⚫ | drug_name = Insulin Detemir


<!--Clinical data--> <!-- Clinical data -->| tradename = Levemir
| tradename =
| Drugs.com = {{drugs.com|monograph|insulin_detemir}} | Drugs.com = {{drugs.com|monograph|insulin_detemir}}
| MedlinePlus = a606012 | MedlinePlus = a606012
| DailyMedID = Insulin detemir
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = C | pregnancy_AU = A
| pregnancy_AU_comment =
| pregnancy_category = | pregnancy_category =
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
⚫ | routes_of_administration = ]
⚫ | legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
| ATC_prefix = A10
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
⚫ | ATC_suffix = AE05

<!-- Legal status -->| legal_AU = S4
| legal_AU_comment =
| legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F-->
| legal_BR_comment =
⚫ | legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_CA_comment =
| legal_DE = <!-- Anlage I, II, III or Unscheduled-->
| legal_DE_comment =
| legal_NZ = <!-- Class A, B, C -->
| legal_NZ_comment =
| legal_UK = POM
| legal_UK_comment = <ref>{{cite web | title=Levemir FlexPen 100 units/ml solution for injection in pre-filled pen - Summary of Product Characteristics (SmPC) | website=(emc) | date=21 May 2018 | url=https://www.medicines.org.uk/emc/product/5536/smpc | access-date=14 April 2020}}</ref><ref>{{cite web | title=Levemir InnoLet 100 units/ml solution for injection in pre-filled pen - Summary of Product Characteristics (SmPC) | website=(emc) | date=21 May 2018 | url=https://www.medicines.org.uk/emc/product/7890/smpc | access-date=14 April 2020}}</ref><ref>{{cite web | title=Levemir Penfill 100 units/ml solution for injection in cartridge - Summary of Product Characteristics (SmPC) | website=(emc) | date=21 May 2018 | url=https://www.medicines.org.uk/emc/product/7889/smpc | access-date=14 April 2020}}</ref>
| legal_US = Rx-only | legal_US = Rx-only
| legal_US_comment = <ref name="Levemir FDA label">{{cite web | title=Levemir- insulin detemir injection, solution | website=DailyMed | date=24 March 2020 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d38d65c1-25bf-401d-9c7e-a2c3222da8af | access-date=19 October 2020}}</ref>
⚫ | legal_status =
| legal_EU = Rx-only
⚫ | routes_of_administration = Subcutaneous
| legal_EU_comment = <ref name="Levemir EPAR" />
| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV-->
| legal_UN_comment =
⚫ | legal_status = Rx-only


<!--Pharmacokinetic data--> <!-- Pharmacokinetic data -->| bioavailability = 60% (subcutaneous)
| protein_bound =
| bioavailability = 60% (when administered s.c.)
| protein_bound = | metabolism =
| metabolism =
| elimination_half-life = 5–7 hours | elimination_half-life = 5–7 hours
| duration_of_action = ≤ 24 hours
| excretion = | excretion = <!-- Identifiers -->

⚫ | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
<!--Identifiers-->
⚫ | ChemSpiderID = none
⚫ | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
⚫ | ChemSpiderID = NA
| CAS_number_Ref = {{cascite|changed|??}} | CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = <!-- blanked - oldvalue: 169148-63-4 --> | CAS_number = 169148-63-4
| ATC_prefix = A10 | PubChem =
⚫ | ATC_suffix = AE05
| PubChem =
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB01307 | DrugBank = DB01307
| UNII_Ref = {{fdacite|changed|FDA}} | UNII_Ref = {{fdacite|changed|FDA}}
| UNII = <!-- blanked - oldvalue: 4FT78T86XV --> | UNII = 4FT78T86XV
| KEGG_Ref = {{keggcite|correct|kegg}} | KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D04539 | KEGG = D04539


<!--Chemical data--> <!-- Chemical data -->| C = 267
| H = 402
| C=267 | H=402 | N=64 | O=76 | S=6
| N = 64
| molecular_weight = 5913
| O = 76
| S = 6
}} }}

<!-- Definition and medical uses -->
'''Insulin detemir''', sold under the brand name '''Levemir''' among others, is a long-acting ] form of ] used to treat both ] and ] ].<ref name=AHFS2019/> It is used by ].<ref name=AHFS2019/> It is effective for up to 24 hours.<ref name=AHFS2019/>

<!-- Side effects and mechanisms -->
Common side effects include ], ], pain at the site of injection, and weight gain.<ref name=AHFS2019/> Use in ] and ] appears safe.<ref name=Preg2019>{{cite web | title=Insulin detemir (Levemir) Use During Pregnancy | website=Drugs.com | date=12 June 2019 | url=https://www.drugs.com/pregnancy/insulin-detemir.html | access-date=14 April 2020}}</ref> It works by increasing the amount of ] that tissues take in and decreasing the amount of glucose made by the liver.<ref name=AHFS2019>{{cite web |title=Insulin Detemir Monograph for Professionals |url=https://www.drugs.com/monograph/insulin-detemir.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |access-date=3 March 2019 }}</ref>

<!-- Society and culture -->
Insulin detemir was approved for medical use in the European Union in June 2004, and in the United States in June 2005.<ref name="Levemir EPAR">{{cite web | title=Levemir EPAR | website=] (EMA) | date=6 August 2009 | url=https://www.ema.europa.eu/en/medicines/human/EPAR/levemir | access-date=14 April 2020}}</ref><ref name=AHFS2019/><ref>{{cite web | title=Drug Approval Package: Levemir Insulin Detemir Injection; NDA #021536 | website=U.S. ] (FDA) | date=26 July 2005 | url=https://www.accessdata.fda.gov/drugsatfda_docs/nda/2005/021-536_LevemirTOC.cfm | access-date=14 April 2020}}</ref> It is on the ].<ref name="WHO23rd">{{cite book | vauthors = ((World Health Organization)) | title = The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023) | year = 2023 | hdl = 10665/371090 | author-link = World Health Organization | publisher = World Health Organization | location = Geneva | id = WHO/MHP/HPS/EML/2023.02 | hdl-access=free }}</ref> In 2022, it was the 127th most commonly prescribed medication in the United States, with more than 4{{nbsp}}million prescriptions.<ref>{{cite web | title=The Top 300 of 2022 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=30 August 2024 | archive-date=30 August 2024 | archive-url=https://web.archive.org/web/20240830202410/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Insulin Detemir Drug Usage Statistics, United States, 2013 - 2022 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/InsulinDetemir | access-date = 30 August 2024 }}</ref>

==Medical use==
It is used to treat both ] and ] ].<ref name=AHFS2019/> A recent Cochrane systematic review<ref name=":0">{{cite journal | vauthors = Hemmingsen B, Metzendorf MI, Richter B | title = (Ultra-)long-acting insulin analogues for people with type 1 diabetes mellitus | journal = The Cochrane Database of Systematic Reviews | volume = 3 | issue = 3 | pages = CD013498 | date = March 2021 | pmid = 33662147 | pmc = 094220 | doi = 10.1002/14651858.cd013498.pub2 }}</ref> also compared the effects of insulin detemir to ] and other insulin analogues (], ]) in both children and adults with Type 1 diabetes. With respect to blood sugar management, it appears to work better than NPH insulin, however this finding was inconsistent across included and previous studies.<ref name="AHFS2019" /><ref name=":0" /> In the same systematic review no other clinically significant differences were found between different insulin analogues in either adults nor children.<ref name=":0" />

==Side effects==
Common side effects include ], ], pain at the site of injection, and weight gain.<ref name=AHFS2019/> Use in ] and ] appears safe.<ref name=Preg2019/>

==Chemistry==
It is an insulin analogue in which a ] (]) is bound to the ] amino acid at position B29. It is quickly absorbed after which it binds to ] in the blood through its fatty acid at position B29. It then slowly dissociates from this complex.{{cn|date=May 2022}}

==Society and culture==
In June 2009, the US ] (FDA) issued a public health advisory for insulin determir after learning that 129,000 stolen vials reappeared and were being sold in the U.S. market. The FDA warned that the stolen vials "may not have been stored and handled properly and may be dangerous for patients to use." The stolen vials were identified as lots XZF0036, XZF0037, and XZF0038.<ref>{{cite web |title=FDA Issues Public Health Advisory Regarding Levemir Insulin |website=] |url=https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm166358.htm |date=13 June 2009 |archive-url=https://web.archive.org/web/20090617072719/https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm166358.htm |archive-date=17 June 2009 |url-status=dead |access-date=9 March 2019}}</ref>

== References ==
{{Reflist}}

{{Oral hypoglycemics and insulin analogs}}
{{Portal bar | Medicine}}

⚫ {{DEFAULTSORT:Insulin Detemir}}
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