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Latest revision as of 13:35, 14 January 2022 edit undoSpicy (talk | contribs)Autopatrolled, Checkusers, Administrators63,757 edits →Food additive: rm unsourced medical claim |
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{{Use dmy dates|date=August 2021}} |
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{{chembox |
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{{chembox |
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| verifiedrevid = 400119970 |
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|ImageFile=Ferrous gluconate.png |
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| verifiedrevid = 406547047 |
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|ImageSize= |
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| ImageFile = Ferrous gluconate.png |
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|IUPACName=iron; (2R,3R,4S,5S)-2,3,4,5,6-pentahydroxyhexanoic acid {{Citation needed|date=April 2010}} |
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|OtherNames= |
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| SystematicName=Iron; (2''R'',3''R'',4''S'',5''S'')-2,3,4,5,6-pentahydroxyhexanoic acid |
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|Section1= {{Chembox Identifiers |
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| OtherNames = |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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|Section1={{Chembox Identifiers |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 19953133 |
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| ChemSpiderID = 19953133 |
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| InChI = 1/2C6H12O7.Fe/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1 |
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| InChI = 1/2C6H12O7.Fe/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1 |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = VRIVJOXICYMTAG-IYEMJOQQSA-L |
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| StdInChIKey = VRIVJOXICYMTAG-IYEMJOQQSA-L |
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| CASNo_Ref = {{cascite|correct|CAS}} |
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| CASNo=299-29-6 {{Citation needed|date=April 2010}} |
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| CASNo=299-29-6 |
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| PubChem=9291 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| SMILES = .O((O)C()=O)(O)(O)CO.C(=O)(O)(O)(O)(O)CO |
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| UNII = 781E2AXH0K |
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}} |
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| PubChem = 9291 |
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|Section2= {{Chembox Properties |
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| SMILES = .O((O)C()=O)(O)(O)CO.C(=O)(O)(O)(O)(O)CO}} |
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| Formula=C<sub>12</sub>H<sub>24</sub>FeO<sub>14</sub> |
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|Section2={{Chembox Properties |
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| MolarMass=448.156 |
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| Formula = FeC<sub>12</sub>H<sub>22</sub>O<sub>14</sub> |
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| Appearance= |
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| MolarMass = 446,14528 g/mol |
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| Density= |
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| Appearance = light yellow to brown powder |
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| MeltingPt= |
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| Odor = slight caramel odor |
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| MeltingPtC= 188 |
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| MeltingPt_notes = dihydrate |
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}} |
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| Solubility = soluble |
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|Section3= {{Chembox Hazards |
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| SolubleOther = soluble in ]<br>negligible in ]}} |
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|Section6={{Chembox Pharmacology |
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| ATCCode_prefix = B03 |
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| ATCCode_suffix = AA03 |
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}} |
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| ATC_Supplemental = <br>{{ATC|B03|AD05}} (combination with ])}} |
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|Section7={{Chembox Hazards |
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'''Iron(II) gluconate''', or '''ferrous gluconate''',<ref></ref> is a black compound often used as an iron supplement. It is the iron(II) salt of ]. It is marketed under brand names such as ''Fergon'', ''Ferralet'', and ''Simron''.<ref></ref> It is also present in the combination supplement ], a vitamin mixture created by ] and used in the religion ].<ref name="all-about-radiation">{{cite book | last = Hubbard | first = L. Ron | isbn = 9780884040620 | title = ] }}</ref> |
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| ExternalSDS = }}}} |
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'''Iron(II) gluconate''', or '''ferrous gluconate''',<ref></ref> is a black compound often used as an iron supplement. It is the iron(II) salt of ]. It is marketed under brand names such as ''Fergon'', ''Ferralet'' and ''Simron''.<ref></ref> |
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== Uses == |
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==Uses== |
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===Medical=== |
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Ferrous gluconate is effectively used in the treatment of ]. The use of this compound compared with other ] preparations results in satisfactory ] responses, a high percentage utilization of iron, and daily increase in ] that a normal level occurs in a reasonably short time.<ref>{{cite journal |author=Paul Reznikoff and Walther F. Goebel |year=1937 |month=July |title=THE USE OF FERROUS GLUCONATE IN THE TREATMENT OF HYPOCHROMIC ANEMIA |journal=J Clin Invest. |pmid=16694502 |volume=16 |issue=4 |pmc=424894 |pages=547–554 |doi=10.1172/JCI100881 |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC424894/pdf/jcinvest00545-0065.pdf |accessdate=2010-02-10}}</ref> |
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{{Main|Iron supplement}} |
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Ferrous gluconate is effectively used in the treatment of ]. The use of this compound compared with other ] preparations results in satisfactory ] responses, a high percentage utilization of iron, and daily increase in ] that a normal level occurs in a reasonably short time.<ref>{{cite journal | doi=10.1172/JCI100881 | title=The Use of Ferrous Gluconate in the Treatment of Hypochromic Anemia | year=1937 | last1=Reznikoff | first1=Paul | last2=Goebel | first2=Walther F. | journal=Journal of Clinical Investigation | volume=16 | issue=4 | pages=547–54 | pmid=16694502 | pmc=424894}}</ref> |
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===Food additive=== |
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Ferrous gluconate is also used as a ] when processing black ]s. It imparts a uniform jet black colour to the olives.<ref></ref> |
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Ferrous gluconate is also used as a ] when processing black ]s. It is represented by the food labeling ] E579 in Europe. It imparts a uniform jet black color to the olives.<ref></ref><ref>Antonio Higinio Sánchez Gómez, Pedro García García and Luis Rejano Navarro (Spain 2006). "", p. 92, from digital.csic.es. 2018-04-22. Retrieved 2019-03-01.</ref> |
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== Toxicity == |
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==Toxicity== |
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Ferrous gluconate may be toxic in case of overdose. Children may show signs of toxicity with ingestions of 10–20 mg/kg of elemental iron. Serious toxicity may result from ingestions of more than 60 mg/kg. Iron exerts both local and systemic effects and is corrosive to the GI ] and can have a negative impact on the heart and blood (], low ], fast and weak pulse, ]), lungs, liver, gastrointestinal system (diarrhea, nausea, vomiting blood), nervous system (chills, dizziness, ], convulsions, headache), and skin (flushing, loss of color, bluish-colored lips and fingernails).<ref> |
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Ferrous gluconate may be ] in case of overdose. Children may show signs of toxicity with ingestions of 10–20 mg/kg of elemental iron. Serious toxicity may result from ingestions of more than 60 mg/kg. Iron exerts both local and systemic effects: it is corrosive to the gastrointestinal ], it can have a negative impact on the heart and blood (], low ], fast and weak pulse, ]), lungs, liver, gastrointestinal system (diarrhea, nausea, vomiting blood), nervous system (chills, dizziness, ], convulsions, headache), and skin (flushing, loss of color, bluish-colored lips and fingernails).<ref></ref><ref></ref> The symptoms may disappear in a few hours, but then emerge again after 1 or more days. {{citation needed|date=February 2016}} |
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</ref><ref></ref> The symptoms may disappear in a few hours, but then emerge again after 1 or more days. |
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==See also== |
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== Compendial status == |
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* ] <ref name=ib29>{{cite web |
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| last = The British Pharmacopoeia Secretariat |
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| first = |
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| title = Index, BP 2009 |
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| work = |
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| year = 2009 |
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| url = http://www.pharmacopoeia.co.uk/pdf/2009_index.pdf |
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| accessdate = 5 July 2009 }}</ref> |
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{{Expand section|date=April 2010}} |
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*] |
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==Notes and references== |
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*] |
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==References== |
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<references/> |
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<references/> |
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{{Iron compounds}} |
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== See also == |
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{{Antianemic preparations}} |
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* ] |
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{{DEFAULTSORT:Iron(Ii) Gluconate}} |
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