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Revision as of 14:51, 2 December 2010 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers from ChemSpider, CommonChemistry and FDA for the Chem/Drugbox validation project - Updated: InChI1->InChI StdInChI StdInChIKey.← Previous edit Latest revision as of 05:23, 6 November 2024 edit undoBIG DADDY Dunkleosteus (talk | contribs)Extended confirmed users1,044 editsNo edit summary 
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{{short description|Ore of lanthanum metal}}
{{Chembox {{Chembox
| Verifiedfields = changed
| Name = Lanthanum carbonate
| Watchedfields = changed
| ImageFile =
| verifiedrevid = 400130079
<!-- | ImageSize = 200px -->
| Name = Lanthanum carbonate
| ImageName =
| IUPACName = Lanthanum carbonate | ImageFile = File:Lanthanum-carbonate-3D-balls.png
| OtherNames = | ImageName =
| IUPACName = Lanthanum carbonate
| Section1 = {{Chembox Identifiers
| OtherNames = Fosrenol
| ChemSpiderID = 147758
|Section1={{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 147758
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 2096647
| PubChem = 168924 | PubChem = 168924
| KEGG = D04667
| InChI = 1/3CH2O3.2La/c3*2-1(3)4;;/h3*(H2,2,3,4);;/q;;;2*+3/p-6 | InChI = 1/3CH2O3.2La/c3*2-1(3)4;;/h3*(H2,2,3,4);;/q;;;2*+3/p-6
| InChIKey = NZPIUJUFIFZSPW-CYFPFDDLAT | InChIKey = NZPIUJUFIFZSPW-CYFPFDDLAT
| SMILES = ..O=C().C()=O.C()=O | SMILES = ..O=C().C()=O.C()=O
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/3CH2O3.2La/c3*2-1(3)4;;/h3*(H2,2,3,4);;/q;;;2*+3/p-6 | StdInChI = 1S/3CH2O3.2La/c3*2-1(3)4;;/h3*(H2,2,3,4);;/q;;;2*+3/p-6
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = NZPIUJUFIFZSPW-UHFFFAOYSA-H | StdInChIKey = NZPIUJUFIFZSPW-UHFFFAOYSA-H
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo = 54451-24-0
| RTECS = | CASNo = 587-26-8
| UNII_Ref = {{fdacite|correct|FDA}}
}}
| UNII = 0M78EU4V9H
| Section2 = {{Chembox Properties
| EC_number = 209-599-5
| Formula = La<sub>2</sub>(CO<sub>3</sub>)<sub>3</sub>
}}
| MolarMass = 457.85 g/mol
|Section2={{Chembox Properties
| Appearance = White, hygroscopic
| Formula = La{{sub|2}}(CO<sub>3</sub>)<sub>3</sub>
| Density = 2.6–2.7 g/cm{{sup|3}}
| MolarMass = 457.838 g/mol
| Solubility = Insoluble
| Appearance = White powder, hygroscopic
| MeltingPt = ''decomposes''
| Density = 2.6–2.7 g/cm{{sup|3}}
| BoilingPt =
| Solubility = negligible
| pKa =
| SolubleOther = soluble in acids
| pKb =
| MeltingPt = ''decomposes''
| BoilingPt =
| pKa =
| pKb =
}} }}
| Section3 = {{Chembox Structure |Section3={{Chembox Structure
| Coordination = | Coordination =
| CrystalStruct = | CrystalStruct =
| Dipole = | Dipole =
}} }}
| Section7 = {{Chembox Hazards | Section6 = {{Chembox Pharmacology
| Pharmacology_ref =
| ExternalMSDS =
| MainHazards = | ATCCode_prefix = V03
| FlashPt = | ATCCode_suffix = AE03
| RPhrases = | ATC_Supplemental =
| SPhrases = | ATCvet =
| Licence_EU =
| INN =
| INN_EMA =
| Licence_US =
| Legal_status =
| Legal_AU =
| Legal_AU_comment =
| Legal_CA = Rx-only
| Legal_CA_comment =
| Legal_NZ =
| Legal_NZ_comment =
| Legal_UK =
| Legal_UK_comment =
| Legal_US =
| Legal_US_comment =
| Legal_EU =
| Legal_EU_comment =
| Legal_UN =
| Legal_UN_comment =
| Pregnancy_category =
| Pregnancy_AU =
| Pregnancy_AU_comment =
| Dependence_liability =
| AdminRoutes =
| Bioavail =
| ProteinBound =
| Metabolism =
| Metabolites =
| OnsetOfAction =
| HalfLife =
| DurationOfAction =
| Excretion =
}} }}
| Section8 = {{Chembox Related |Section7={{Chembox Hazards
| ExternalSDS =
| OtherAnions = ]
| OtherCpds = | MainHazards =
| FlashPt =
}} }}
|Section8={{Chembox Related
| OtherAnions = ]
| OtherCompounds =
}} }}
}}
'''Lanthanum carbonate''', ]<sub>2</sub>(]]<sub>3</sub>)<sub>3</sub>, is the ] formed by ](III) ]s and ] ]s. It is an ore of ] metal, along with ].
'''Lanthanum carbonate''', ]{{sub|2}}(]]<sub>3</sub>)<sub>3</sub>, is the ] formed by ](III) ]s and ] ]s. It is an ore of ] metal (]), along with ].


== Chemistry == == Chemistry ==
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* for production of certain ], such as La{{sub|2-''x''}}Sr{{sub|''x''}}CuO{{sub|2}}. * for production of certain ], such as La{{sub|2-''x''}}Sr{{sub|''x''}}CuO{{sub|2}}.


== Medical uses ==
== Human and veterinary medicine ==
Lanthanum carbonate is used in ] as a ]<ref>{{cite web | last = Editorial Staff | title = Lanthanum Carbonate | work = All Micromedex Systems | publisher = Micromedex, Inc. | month = December | year = 2004 | url = http://www.micromedex.com/products/updates/drugdex_updates/de/lanthanum.html | accessdate = 2007-11-25 |archiveurl = http://web.archive.org/web/20070914035811/http://www.micromedex.com/products/updates/drugdex_updates/de/lanthanum.html <!-- Bot retrieved archive --> |archivedate = 2007-09-14}}</ref>. As a medication it is sold under the trade name '''Fosrenol''' by the pharmaceutical company ]. Fosrenol is the largest of all pills filled in community pharmacies. Sometimes patients forget that fosrenol is not swallowed whole, but instead should be chewed. This has led to severe choking. It is ] for the treatment of ], primarily in patients with ]. It is taken with meals and binds to dietary ], preventing phosphate from being absorbed by the ]. For cats suffering from ] it is available under the trade name '''Renalzin''' by ].<ref>{{cite web | author = Bayer Animal Health | url = http://www.animalhealth.bayerhealthcare.com/fileadmin/presslounge/att/2008-09-0441E.pdf |format=PDF| date = 26 September 2008 | title = Bayer Animal Health launches Renalzin for Cats | accessdate = 2008-09-30}}</ref> Lanthanum carbonate is used in ] as a ].<ref>{{cite web|last=Editorial Staff |title=Lanthanum Carbonate |work=All Micromedex Systems |publisher=Micromedex, Inc. |date=December 2004 |url=http://www.micromedex.com/products/updates/drugdex_updates/de/lanthanum.html |accessdate=2007-11-25 |archiveurl=https://web.archive.org/web/20070914035811/http://www.micromedex.com/products/updates/drugdex_updates/de/lanthanum.html |archivedate=2007-09-14 |url-status=dead }}</ref> As a medication it is sold under the trade name '''Fosrenol''' by the pharmaceutical company ]. Due to its large size (1000&nbsp;mg tablet is 2.2&nbsp;cm in diameter), it may be possible to choke on the tablet if it is not chewed. It is ] for the treatment of ], primarily in patients with ]. It is taken with meals and binds to dietary ], preventing phosphate from being absorbed by the ]. For cats with ] it is available under the trade name '''Renalzin''' by ].<ref>{{cite web | author = Bayer Animal Health | url = http://www.animalhealth.bayerhealthcare.com/fileadmin/presslounge/att/2008-09-0441E.pdf | date = 26 September 2008 | title = Bayer Animal Health launches Renalzin for Cats | accessdate = 2008-09-30 | archive-url = https://web.archive.org/web/20110707214915/http://www.animalhealth.bayerhealthcare.com/fileadmin/presslounge/att/2008-09-0441E.pdf | archive-date = 7 July 2011 | url-status = dead }}</ref>

However, when lanthanum carbonate is used for treating hyperphosphatemia, its side effects, namely ], muscular cramping, and ], should be clinically monitored.<ref>{{cite journal |doi=10.1056/NEJMra0912522|pmid=20375408|title=Oral Phosphate Binders in Patients with Kidney Failure|journal=New England Journal of Medicine|volume=362|issue=14|pages=1312–24|year=2010|last1=Tonelli|first1=Marcello|last2=Pannu|first2=Neesh|last3=Manns|first3=Braden|s2cid=22322676}}</ref>


== Other applications == == Other applications ==
Lanthanum carbonate is also used for the tinting of glass, for water treatment, or as a ] for ]. Lanthanum carbonate is also used for the tinting of glass,{{citation needed|date=January 2019}} for water treatment, and as a ] for ].


== References == == References ==
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== External links == == External links ==
* - medlineplus.org * - medlineplus.org
* - the manufacturer's web site * - the manufacturer's web site
* - Drugs.com * - Drugs.com
* - Medscape.com * - Medscape.com
* - PhosphorusControl.com * - PhosphorusControl.com
* *

{{Lanthanum compounds}} {{Lanthanum compounds}}
{{Carbonates}}
{{Drugs for treatment of hyperkalemia and hyperphosphatemia}} {{Drugs for treatment of hyperkalemia and hyperphosphatemia}}


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