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{{Short description|Combination drug used to treat high blood pressure}} |
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{{drugbox |
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{{Use dmy dates|date=September 2019}} |
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| type = combo |
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{{cs1 config |name-list-style=vanc |display-authors=6}} |
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| component1 = Lisinopril |
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{{Infobox drug |
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| class1 = ] |
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| component2 = Hydrochlorothiazide |
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| verifiedrevid = 447439314 |
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| class2 = ] ] |
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| type = combo |
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| CAS_number = |
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| image = Lisinoprilhctz.png |
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| ATC_prefix = C09 |
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| alt = |
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| caption = Lisinopril (top) and hydrochlorothiazide (bottom) |
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| ATC_suffix = BA03 |
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| PubChem = |
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| DrugBank = |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = D |
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| pregnancy_category= |
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
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| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_status = Rx-only |
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| routes_of_administration = Oral |
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}}'''Lisinopril/hydrochlorothiazide''' (trade name '''Prinzide''' by ], '''Zestoretic''' by ], and many others) is a combination of the drugs ], an ], and ], a ]. It is used to control ]. |
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<!-- Combo data --> |
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==References== |
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| component1 = Lisinopril |
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* Drugs.com: |
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| class1 = ] |
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* Drugs.com: |
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| component2 = Hydrochlorothiazide |
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| class2 = ] ] |
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<!-- Clinical data --> |
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{{Agents acting on the renin-angiotensin system}} |
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| tradename = Zestoretic, Prinzide, others |
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| Drugs.com = {{drugs.com|cons|hydrochlorothiazide-and-lisinopril}} |
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| MedlinePlus = a601070 |
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| DailyMedID = Lisinopril and hydrochlorothiazide |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_AU_comment = |
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| pregnancy_category = Contraindicated |
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| routes_of_administration = ] |
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| ATC_prefix = C09 |
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| ATC_suffix = BA03 |
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| ATC_supplemental = |
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<!-- Legal status --> |
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] |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled --> |
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] |
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| legal_AU_comment = |
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| legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F --> |
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| legal_BR_comment = |
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| legal_CA = Rx-only |
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| legal_CA_comment = <ref>{{cite web | title=Product monograph brand safety updates | website=Health Canada | date=February 2024 | url=https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database/label-safety-assessment-update/product-monograph-brand-safety-updates.html | access-date=24 March 2024}}</ref> |
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| legal_DE = <!-- Anlage I, II, III or Unscheduled --> |
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| legal_DE_comment = |
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| legal_NZ = <!-- Class A, B, C --> |
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| legal_NZ_comment = |
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| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C --> |
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| legal_UK_comment = |
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| legal_US = Rx-only |
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| legal_US_comment = <ref name="Zestoretic FDA label">{{cite web | title=Zestoretic- lisinopril and hydrochlorothiazide tablet | website=DailyMed | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0d3a966f-f937-05a8-a90f-5aa52ebbd613 | access-date=9 February 2022}}</ref> |
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| legal_EU = |
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| legal_EU_comment = |
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| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV --> |
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| legal_UN_comment = |
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| legal_status = Rx-only |
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<!-- Identifiers --> |
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| CAS_number = 151063-30-8 |
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| CAS_supplemental = |
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| PubChem = |
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| PubChemSubstance = |
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| IUPHAR_ligand = |
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| DrugBank = |
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| ChemSpiderID = |
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| UNII = |
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| KEGG = D10268 |
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| ChEBI = |
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| ChEMBL = |
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| synonyms = lisinopril/hctz |
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}} |
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<!-- Definition and medical uses --> |
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'''Lisinopril/hydrochlorothiazide''', sold under the brand name '''Zestoretic''' among others, is a ] medication used for the treatment of ] (hypertension).<ref name="Zestoretic FDA label" /> It contains ], an ], and ], a ].<ref name="Zestoretic FDA label" /><ref name=MTM2018/> Typically, it becomes an option once a person is doing well on the individual components.<ref name=BNF74/> It is taken ].<ref name=MTM2018/> |
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<!-- Side effects and mechanism --> |
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Common side effects include ], ], cough, and feeling tired.<ref name="Zestoretic FDA label" /> Severe side effects may include ] and ].<ref name="Zestoretic FDA label" /> Use during pregnancy may harm the baby.<ref name="Zestoretic FDA label" /> |
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<!-- Society and culture --> |
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The combination was approved for medical use in the United States in 1989.<ref name=MTM2018>{{cite web |title=Hydrochlorothiazide and lisinopril Uses, Side Effects & Warnings |url=https://www.drugs.com/mtm/hydrochlorothiazide-and-lisinopril.html |website=Drugs.com |publisher=Cerner Multum |access-date=26 December 2018 }}</ref> It is on the ].<ref name="WHO23rd">{{cite book | vauthors = ((World Health Organization)) | title = The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023) | year = 2023 | hdl = 10665/371090 | author-link = World Health Organization | publisher = World Health Organization | location = Geneva | id = WHO/MHP/HPS/EML/2023.02 | hdl-access=free }}</ref> It is available as a ].<ref name=BNF74>{{cite book|title=British national formulary : BNF 74|date=2017|publisher=British Medical Association|isbn=978-0857112989|page=166|edition=74}}</ref> In 2022, the combination was the 53rd most commonly prescribed medication in the United States, with more than 12{{nbsp}}million prescriptions.<ref>{{cite web | title=The Top 300 of 2022 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=30 August 2024 | archive-date=30 August 2024 | archive-url=https://web.archive.org/web/20240830202410/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Hydrochlorothiazide; Lisinopril Drug Usage Statistics, United States, 2013 - 2022 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/HydrochlorothiazideLisinopril | access-date = 30 August 2024 }}</ref> |
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== Medical uses == |
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Lisinopril/hydrochlorothiazide is ] for the treatment of ], to lower blood pressure.<ref name="Zestoretic FDA label" /> |
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== Adverse effects == |
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The US ] ] for the combination contains a ] about harm to the baby.<ref name="Zestoretic FDA label" /> |
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== References == |
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{{Reflist}} |
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{{Agents acting on the renin-angiotensin system}} |
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{{Portal bar | Medicine}} |
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{{Authority control}} |
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{{DEFAULTSORT:Lisinopril Hydrochlorothiazide}} |
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