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{{chembox {{Chembox
| Verifiedfields = changed
| verifiedrevid = 400292163
| Watchedfields = changed
| verifiedrevid = 430673459
| ImageFile = LuCl3structure.jpg | ImageFile = LuCl3structure.jpg
| IUPACName = Lutetium(III) chloride | IUPACName = Lutetium(III) chloride
| OtherNames = Lutetium chloride, lutetium trichloride | OtherNames = Lutetium chloride, lutetium trichloride
| Section1 = {{Chembox Identifiers | Section1 = {{Chembox Identifiers
| CASNo_Ref = {{cascite|correct|??}}
| Abbreviations =
| CASNo = 10099-66-8
| Abbreviations =
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 23297 | ChemSpiderID = 23297
| EC_number = 233-240-1
| MeSHName =
| ChEBI =
| KEGG_Ref =
| KEGG =
| PubChem = 24919
| RTECS = OK8400000
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 2VY5D2E2HC
| InChI = 1S/3ClH.Lu/h3*1H;/q;;;+3/p-3 | InChI = 1S/3ClH.Lu/h3*1H;/q;;;+3/p-3
| InChIKey = AEDROEGYZIARPU-DFZHHIFOAO | InChIKey = AEDROEGYZIARPU-DFZHHIFOAO
Line 15: Line 28:
| StdInChIKey = AEDROEGYZIARPU-UHFFFAOYSA-K | StdInChIKey = AEDROEGYZIARPU-UHFFFAOYSA-K
| InChIKey1 = AEDROEGYZIARPU-UHFFFAOYSA-K | InChIKey1 = AEDROEGYZIARPU-UHFFFAOYSA-K
| CASNo = 10099-66-8
| EINECS =
| PubChem = 24868595
| SMILES = Cl(Cl)Cl | SMILES = Cl(Cl)Cl
}}
| InChI =
| RTECS = OK8400000
| MeSHName =
| ChEBI =
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG =
| ATCCode_prefix =
| ATCCode_suffix =
| ATC_Supplemental =}}
| Section2 = {{Chembox Properties | Section2 = {{Chembox Properties
| Formula = LuCl<sub>3</sub> | Formula = LuCl<sub>3</sub>
| MolarMass = 281.325 g/mol | MolarMass = 281.325 g/mol
| Appearance = colorless or white ] crystals | Appearance = colorless or white ] crystals
| Density = 3.98 g/cm³ | Density = 3.98 g/cm<sup>3</sup>
| MeltingPtC = 925
| MeltingPt = 905°C<ref name="handchem">
| MeltingPt_ref = <ref name="handchem">
{{Citation | last = Lide | first = David R. | year = 1998 {{Citation | last = Lide | first = David R. | year = 1998
| title = Handbook of Chemistry and Physics | title = Handbook of Chemistry and Physics
| edition = 87 | publication-place = Boca Raton, FL | publisher = CRC Press | edition = 87 | location = Boca Raton, Florida | publisher = CRC Press
| isbn = 0849305942 | pages = 472 | isbn = 0-8493-0594-2 | pages = 472
| url = http://books.google.com/?id=lFjg0L-uOxoC&pg=PT857 | accessdate = 2008-06-27 | url = https://books.google.com/books?id=lFjg0L-uOxoC&pg=PT857 | access-date = 2008-06-27
}}</ref> }}</ref>
| BoilingPt = ] above 750°C<ref name="web"> | BoilingPt = ] above 750°C<ref name="web">
{{cite web |url= http://202.114.88.54/g/web18/wangluo/webelements/webelements/compounds/text/lu/cl3lu1-10099668.html |title= Chemistry: Periodic Table: Lutetium: compound data (lutetium (III) chloride) |accessdate=2008-06-27 |publisher= WebElements |date= }}</ref> {{cite web |url= https://webelements.com/compounds/lutetium/lutetium_trichloride.html |title= Chemistry: Periodic Table: Lutetium: compound data (lutetium (III) chloride) |access-date= 2024-09-06 |publisher= WebElements }}</ref>
| Solubility = soluble<ref name="handin"> | Solubility = soluble<ref name="handin">
{{Citation | last = Perry | first = Dale L. | last2 = Phillips {{Citation | last1 = Perry | first1 = Dale L. | last2 = Phillips
| first2 = Sidney L. | year = 1995 | first2 = Sidney L. | year = 1995
| title = Handbook of Inorganic Compounds | publisher = CRC Press | title = Handbook of Inorganic Compounds | publisher = CRC Press
| isbn = 0849386713 | pages = 232 | isbn = 0-8493-8671-3 | pages = 232
| url = http://books.google.com/?id=0fT4wfhF1AsC&pg=PA232 | accessdate = 2008-06-27 | url = https://books.google.com/books?id=0fT4wfhF1AsC&pg=PA232 | access-date = 2008-06-27
}}</ref> }}</ref>
}}
| SolubleOther =
| Solvent =
| pKa =
| pKb = }}
| Section3 = {{Chembox Structure | Section3 = {{Chembox Structure
| CrystalStruct = ], ] | CrystalStruct = ], ]
| SpaceGroup = C2/m, No. 12 | SpaceGroup = C2/m, No. 12
}} }}
| Section5 = {{Chembox Pharmacology
| Licence_EU = yes
| INN_EMA = Lutetium (177 Lu) chloride
}}
| Section7 = {{Chembox Hazards | Section7 = {{Chembox Hazards
| ExternalMSDS = | ExternalSDS =
| EUClass = | MainHazards = Irritant
| EUIndex =
| MainHazards = '''Xi''' (Irritant)
| NFPA-H = 2 | NFPA-H = 2
| NFPA-F = 0 | NFPA-F = 0
| NFPA-R = 1 | NFPA-R = 1
| NFPA-O = | NFPA-S =
| GHS_ref=<ref>{{cite web |url= http://www.sigmaaldrich.com/catalog/search/ProductDetail/ALDRICH/450960 |title= 450960 Lutetium(III) chloride anhydrous, powder, 99.99% trace metals basis |access-date=2008-06-27 |publisher= Sigma-Aldrich}}</ref><ref>{{cite web |title=Lutetium chloride |url=https://pubchem.ncbi.nlm.nih.gov/compound/24919#section=Safety-and-Hazards |website=pubchem.ncbi.nlm.nih.gov |language=en}}</ref>
| RPhrases = {{R36/37/38}}
| GHSPictograms = {{GHS07}}
| SPhrases = {{S26}}, {{S36}}<ref name="sa">
| GHSSignalWord = Warning
{{cite web |url= http://www.sigmaaldrich.com/catalog/search/ProductDetail/ALDRICH/450960 |title= 450960 Lutetium(III) chloride anhydrous, powder, 99.99% trace metals basis |accessdate=2008-06-27 |publisher= Sigma-Aldrich|date= }}</ref>
| HPhrases = {{H-phrases|315|319|335}}
| RSPhrases =
| PPhrases = {{P-phrases|261|264|271|280|302+352|304+340|305+351+338|312|321|332+313|337+313|362|403+233|405|501}}
| FlashPt =
}}
| Autoignition =
| ExploLimits =
| PEL = }}
| Section8 = {{Chembox Related | Section8 = {{Chembox Related
| OtherAnions = ] | OtherAnions = ]
| OtherCations = ]<br />] | OtherCations = ]<br>]<br />]
}}
}} }}
}}

'''Lutetium(III) chloride''' or '''lutetium trichloride''' is the ] composed of ] and ] with the ] LuCl<sub>3</sub>. It forms ] white ] crystals<ref name="handchem"/> and also a hygroscopic hexahydrate LuCl<sub>3</sub>·6H<sub>2</sub>O.<ref>{{Cite web|url=https://www.sigmaaldrich.com/catalog/product/aldrich/542075|title=Lutetium(III) chloride hexahydrate 542075|website=Sigma-Aldrich|access-date=2019-07-24}}</ref> Anhydrous lutetium(III) chloride has the ] (AlCl<sub>3</sub>) layer structure with octahedral lutetium ions.<ref>Wells A.F. (1984) ''Structural Inorganic Chemistry'' 5th edition Oxford Science Publications {{ISBN|0-19-855370-6}}</ref>


Lutetium-177, a radioisotope that can be derived from lutetium(III) chloride, is used in targeted cancer therapies.<ref>{{Cite journal |last=Sgouros |first=George |last2=Bodei |first2=Lisa |last3=McDevitt |first3=Michael R. |last4=Nedrow |first4=Jessie R. |date=September 2020 |title=Radiopharmaceutical therapy in cancer: clinical advances and challenges |url=https://www.nature.com/articles/s41573-020-0073-9 |journal=Nature Reviews Drug Discovery |language=en |volume=19 |issue=9 |pages=589–608 |doi=10.1038/s41573-020-0073-9 |issn=1474-1784|pmc=7390460 }}</ref> When lutetium-177 is attached to molecules that specifically target cancer cells, it can deliver localized radiation to destroy those cells while sparing surrounding healthy tissue.<ref>{{Cite journal |last=Vyas |first=Madhusudan |date=2021-05-01 |title=Lutetium-177: a flexible radionuclide therapeutic options |url=https://jnm.snmjournals.org/content/62/supplement_1/3039 |journal=Journal of Nuclear Medicine |language=en |volume=62 |issue=supplement 1 |pages=3039–3039 |issn=0161-5505}}</ref> This makes lutetium-177-based treatments especially valuable for cancers that are difficult to treat with traditional methods, such as neuroendocrine tumors and prostate cancer.<ref>{{Cite journal |last=Dash |first=Ashutosh |last2=Pillai |first2=Maroor Raghavan Ambikalmajan |last3=Knapp |first3=Furn F. |date=2015-06-01 |title=Production of 177Lu for Targeted Radionuclide Therapy: Available Options |url=https://link.springer.com/article/10.1007/s13139-014-0315-z |journal=Nuclear Medicine and Molecular Imaging |language=en |volume=49 |issue=2 |pages=85–107 |doi=10.1007/s13139-014-0315-z |issn=1869-3482 |pmc=4463871 |pmid=26085854}}</ref> Additionally, lutetium(III) chloride is used in ]s, materials that emit light when exposed to radiation.<ref>{{Cite journal |last=Vogel |first=W. V. |last2=van der Marck |first2=S. C. |last3=Versleijen |first3=M. W. J. |date=2021-07-01 |title=Challenges and future options for the production of lutetium-177 |url=https://link.springer.com/article/10.1007/s00259-021-05392-2 |journal=European Journal of Nuclear Medicine and Molecular Imaging |language=en |volume=48 |issue=8 |pages=2329–2335 |doi=10.1007/s00259-021-05392-2 |issn=1619-7089 |pmc=8241800 |pmid=33974091}}</ref> These scintillators are crucial in detectors for gamma rays and other high-energy particles, used in both medical diagnostics and in scientific research.<ref>{{Cite journal |last=Das |first=Tapas |last2=Banerjee |first2=Sharmila |date=2016 |title=Theranostic Applications of Lutetium-177 in Radionuclide Therapy |url=https://pubmed.ncbi.nlm.nih.gov/25771364/ |journal=Current Radiopharmaceuticals |volume=9 |issue=1 |pages=94–101 |doi=10.2174/1874471008666150313114644 |issn=1874-4729 |pmid=25771364}}</ref>
'''Lutetium(III) chloride''' or '''lutetium trichloride''' is the ] composed of ] and ] with the ] LuCl<sub>3</sub>. It forms ] white ] crystals<ref name="handchem"/>. Lutetium(III) chloride has the ] (AlCl<sub>3</sub>) layer structure with octahedral lutetium ions.<ref> Wells A.F. (1984) ''Structural Inorganic Chemistry'' 5th edition Oxford Science Publications ISBN 0-19-855370-6 </ref>


==Reactions== ==Reactions==
Pure lutetium metal can be produced from lutetium(III) chloride by heating it together with elemental ]: Pure lutetium metal can be produced from lutetium(III) chloride by heating it together with elemental ]:<ref name="chem">
<ref name="chem">
{{Citation {{Citation
| last = Patnaik | last = Patnaik
| first = Pradyot | first = Pradyot
| author-link = | year = 2004
| title = Handbook of Inorganic Chemicals
| last2 =
| first2 = | location = Amsterdam
| publisher = McGraw-Hill Professional
| author2-link =
| isbn = 0-07-049439-8
| publication-date =
| date = | pages = 244
| url = https://books.google.com/books?id=Xqj-TTzkvTEC&q=%22Lutetium+chloride%22&pg=PA510
| year = 2004
| access-date = 2008-06-27
| title = Handbook of Inorganic Chemicals
| edition =
| volume =
| series =
| publication-place = Amsterdam
| place =
| publisher = McGraw-Hill Professional
| id =
| isbn = 0070494398
| doi =
| oclc =
| pages = 244
| url = http://books.google.com/?id=Xqj-TTzkvTEC&pg=PA510&dq=%22Lutetium+chloride%22
| accessdate = 2008-06-27
}}</ref> }}</ref>
:2LuCl<sub>3</sub> + 3] → 2] + 3] :2 LuCl<sub>3</sub> + 3 ] → 2 ] + 3 ]

==See also==

* ]


==References== ==References==
{{reflist}} {{reflist}}

{{Lutetium compounds}}
{{Chlorides}}
{{Lanthanide halides}}


] ]
] ]
] ]

{{Lutetium compounds}}
{{inorganic-compound-stub}}

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