| Revision as of 11:00, 12 October 2011 editCheMoBot (talk | contribs)Bots141,565 edits Updating {{drugbox}} (no changed fields - added verified revid - updated 'ChemSpiderID_Ref', 'DrugBank_Ref', 'UNII_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'DrugBank_Ref', 'ChEBI_Ref') per [[WP:CHEMVALID|Chem...← Previous edit |
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{{Short description|Pain medication}} |
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{{Globalize/USA|date=February 2011}} |
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{{Redirect2|Percocet|Percs|the band|Percocettes|the supercomputer technology|PERCS|the cleaning chemical PERC|tetrachloroethylene|}} |
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{{Use dmy dates|date=October 2022}} |
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{{cs1 config |name-list-style=vanc |display-authors=6}} |
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{{Drugbox |
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{{Drugbox |
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| Verifiedfields = changed |
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| verifiedrevid = 455186406 |
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| Watchedfields = changed |
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| drug_name = Percocet |
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| verifiedrevid = 455187452 |
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| type = combo |
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| image = |
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| alt = |
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| caption = |
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<!--Combo data--> |
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<!-- Combo data --> |
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| component1 = Oxycodone |
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| type = combo |
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| class1 = ] |
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| component1 = Oxycodone |
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| component2 = Acetaminophen |
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| class1 = ] |
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| class2 = ] |
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| component2 = Paracetamol |
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| class2 = ] |
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<!--Clinical data--> |
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<!-- Clinical data --> |
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| tradename = |
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| tradename = Percocet, others |
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| Drugs.com = {{drugs.com|monograph|oxycodone}} |
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| Drugs.com = {{drugs.com|ppa|oxycodone-and-acetaminophen}} |
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| MedlinePlus = |
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| licence_EU = <!-- EMEA requires brand name --> |
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| DailyMedID = Oxycodone hydrochloride and acetaminophen |
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| licence_US = Percocet |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_category = |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| routes_of_administration = ] |
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| pregnancy_category = C |
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| ATC_prefix = N02 |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
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| ATC_suffix = AJ17 |
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| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> |
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<!-- Legal status --> |
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| legal_US = Schedule II |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled --> |
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| routes_of_administration = ] |
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| legal_AU_comment = |
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| legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F --> |
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| legal_BR_comment = |
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| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_CA_comment = |
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| legal_DE = <!-- Anlage I, II, III or Unscheduled --> |
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| legal_DE_comment = |
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| legal_NZ = <!-- Class A, B, C --> |
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| legal_NZ_comment = |
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| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C --> |
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| legal_UK_comment = |
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| legal_US = Schedule II |
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| legal_US_comment = <ref name="Percocet FDA label">{{cite web | title=Percocet- oxycodone hydrochloride and acetaminophen tablet | website=DailyMed | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4dd36cf5-8f73-404a-8b1d-3bd53bd90c25 | access-date=17 October 2021}}</ref> |
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| legal_EU = |
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| legal_EU_comment = |
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| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV --> |
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| legal_UN_comment = |
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| legal_status = <!-- For countries not listed above --> |
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<!--Identifiers--> |
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<!--Identifiers--> |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 330988-72-2 |
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| CAS_number = 330988-72-2 |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| DrugBank = |
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| StdInChI = 1S/C18H21NO4.C8H9NO2.ClH/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10;1-6(10)9-7-2-4-8(11)5-3-7;/h3-4,13,16,21H,5-9H2,1-2H3;2-5,11H,1H3,(H,9,10);1H/t13-,16+,17+,18-;;/m1../s1 |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 4881971 |
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| StdInChIKey = LPIDDOOVLLQTPE-PCHTVJFHSA-N |
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| KEGG = D02153 |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 4881971 |
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<!--Chemical data--> |
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}} |
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}} |
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The combination ''']/]''' (North American trade name of combination '''Percocet''', North American trade name of latter '''Acetaminophen''') is a ] pain reliever used to treat moderate to severe ] (short-term) ], marketed by ].<ref>http://www.endo.com/pdf/products/Percocet_pack_insert_2.pdf</ref> |
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'''Oxycodone/paracetamol''',<!-- NOTE: DO NOT CHANGE TO ACETAMINOPHEN, per ] --> sold under the brand name '''Percocet''' among others, is a ] of the opioid ] with ] (acetaminophen), used to treat moderate to severe ].<ref name="Percocet FDA label" /> |
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==History== |
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The ] first approved Percocet in 1976, under application ANDA 085106.<ref>{{cite web|title=Drugs@FDA. FDA approved drug products (searchable database)|publisher=U.S. Food and Drug Administration, Center for Drug Evaluation and Research|url=http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm|accessdate=2009-03-30}}</ref> |
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In 2022, it was the 98th most commonly prescribed medication in the United States, with more than 6{{nbsp}}million prescriptions.<ref>{{cite web | title=The Top 300 of 2022 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=30 August 2024 | archive-date=30 August 2024 | archive-url=https://web.archive.org/web/20240830202410/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Acetaminophen; Oxycodone Drug Usage Statistics, United States, 2013 - 2022 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/AcetaminophenOxycodone | access-date = 30 August 2024 }}</ref> |
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==Formulation== |
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As of March 2006, ] produces Percocet in following dosages.<ref name=insert>{{cite web|title=Percocet oxycodone and acetaminophen tablets USP|publisher=Endo Pharmaceuticals|date=2006 November|url=http://www.endo.com/pdf/products/Percocet_pack_insert_4.pdf|accessdate=2009-03-30}}</ref> Percocet ]s are available in six combinations of oxycodone hydrochloride and ], with different appearances and maximum daily ]s:<ref name=insert/> |
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==History== |
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{| class="wikitable" style="text-align:center" |
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The United States ] (FDA) first approved oxycodone/paracetamol in 1976, under application ANDA 085106.<ref>{{cite web | title=Percocet: FDA-Approved Drugs | website=U.S. ] (FDA) | url=https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=085106 | access-date=17 October 2021}}</ref> |
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! Oxycodone Hydrochloride (mg) !! Acetaminophen (mg) !! Tablet Color !! Tablet Shape !! Maximum Daily Dose |
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| 2.5 || 325 || pink || oval || 12 tablets |
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| 5 || 325 || white || round || 12 tablets |
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| 7.5 || 325 || peach || oval || 8 tablets |
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| 7.5 || 500 || peach || capsule-shaped || 8 tablets |
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| 10.0 || 325 || white || oblong || 6 tablets |
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| 10.0 || 650 || yellow || oval || 6 tablets |
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== Society and culture == |
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For the 2.5 mg Oxycodone HCL tablet, the usual dose is 1–2 tablets every six hours as needed for pain; for the other tablets, the usual dose is 1 tablet every six hours as needed for pain.<ref name=insert/> |
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=== Implicated in deaths === |
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In June 2009, an FDA advisory panel recommended that Percocet, ], and every other combination of acetaminophen with ] ]<ref>{{cite web|url=http://www.webmd.com/pain-management/news/20090701/fda-may-restrict-acetaminophen|title=FDA May Restrict Acetaminophen|work=WebMD}}</ref> be limited in their sales because of their contributions to an alleged 400 acetaminophen-related deaths in the U.S. each year, that were attributed to ] and associated liver damage.<ref>{{cite news| url=https://www.nytimes.com/2009/07/01/health/01fda.html | work=] | title=Ban Is Advised on 2 Top Pills for Pain Relief | first=Gardiner | last=Harris | date=30 June 2009 | access-date=22 May 2010}}</ref> |
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In December 2009, a study found a fivefold increase in oxycodone-related deaths in ] (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related deaths in Ontario over the same period.<ref>{{cite journal | vauthors = Dhalla IA, Mamdani MM, Sivilotti ML, Kopp A, Qureshi O, Juurlink DN | title = Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone | journal = CMAJ | volume = 181 | issue = 12 | pages = 891–6 | date = December 2009 | pmid = 19969578 | pmc = 2789126 | doi = 10.1503/cmaj.090784 }}</ref><ref>{{cite journal | vauthors = Fischer B, Rehm J | title = Deaths related to the use of prescription opioids | journal = CMAJ | volume = 181 | issue = 12 | pages = 881–2 | date = December 2009 | pmid = 19969577 | pmc = 2789122 | doi = 10.1503/cmaj.091791 }}</ref><ref>{{cite journal|journal=Canadian Medical Association Journal |date=7 December 2009 |title=Deaths from opioid use have doubled; five-fold increase in oxycodone deaths |access-date=31 May 2012 |url=https://www.sciencedaily.com/releases/2009/12/091207123105.htm}}</ref> |
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==Use in pain management== |
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This medicine, in recent years, has gained favor among the medical community due to its effectiveness and a lower addiction rate than ]. It is very useful to give to someone who is experiencing acute severe pain that is neither ] nor ].{{Citation needed|date=February 2010}} |
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== References == |
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==Implicated in deaths== |
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On June 30, 2009, an FDA advisory panel recommended that Percocet, ], and every other combination of acetaminophen with ] ]<ref>http://www.webmd.com/pain-management/news/20090701/fda-may-restrict-acetaminophen</ref> be removed from the market because of their contributions to an alleged 400 acetaminophen related deaths in the United States each year, that were attributed to ] and associated liver damage.<ref>{{cite news| url=http://www.nytimes.com/2009/07/01/health/01fda.html?em | work=The New York Times | title=Ban Is Advised on 2 Top Pills for Pain Relief | first=Gardiner | last=Harris | date=2009-07-01 | accessdate=2010-05-22}}</ref> |
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In December 2009, the '']'' reported a study finding a fivefold increase in oxycodone-related deaths in Ontario (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related Ontario deaths over the same period.<ref></ref> |
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==References== |
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{{Reflist}} |
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{{Reflist}} |
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{{Analgesics}} |
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== External links== |
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{{Anti-inflammatory products}} |
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* |
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{{Opioidergics}} |
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{{Drug use}} |
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{{DEFAULTSORT:Oxycodone/Paracetamol}} |
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{{Portal bar | Medicine}} |
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] |
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{{Authority control}} |
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] |
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{{DEFAULTSORT:Oxycodone Paracetamol}} |
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{{analgesic-stub}} |
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] |
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] |