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{{Short description|Pharmaceutical drug}} |
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{{Orphan|date=February 2009}} |
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{{More citations needed|date=February 2022}} |
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{{Drugbox |
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{{Drugbox |
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| Verifiedfields = changed |
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| verifiedrevid = 444039701 |
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| Watchedfields = changed |
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| verifiedrevid = 447555440 |
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| IUPAC_name = 1:1 mixture of 2-amino-2-methyl-1-propanol and 8-bromotheophyllinate |
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| IUPAC_name = 1:1 mixture of 2-amino-2-methyl-1-propanol and 8-bromotheophyllinate |
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| image = Pamabrom.png |
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| image = Pamabrom.svg |
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<!--Clinical data--> |
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<!--Clinical data--> |
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| tradename = |
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| tradename = |
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| Drugs.com = {{drugs.com|MTM|pamabrom}} |
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| Drugs.com = {{drugs.com|MTM|pamabrom}} |
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| MedlinePlus = a681004 |
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| MedlinePlus = a681004 |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category = |
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| pregnancy_category = |
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
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| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> |
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| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> |
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| legal_US = OTC |
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| legal_US = OTC |
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| legal_status = |
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| legal_status = |
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| routes_of_administration = |
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| routes_of_administration = |
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<!--Pharmacokinetic data--> |
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<!--Pharmacokinetic data--> |
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| bioavailability = |
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| bioavailability = |
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| protein_bound = |
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| protein_bound = |
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| metabolism = |
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| metabolism = |
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| elimination_half-life = |
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| elimination_half-life = |
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| excretion = |
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| excretion = |
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<!--Identifiers--> |
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<!--Identifiers--> |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 606-04-2 |
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| CAS_number = 606-04-2 |
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| ATC_prefix = none |
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| ATC_prefix = none |
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| ATC_suffix = |
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| ATC_suffix = |
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| PubChem = 11806 |
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| PubChem = 11806 |
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| ChEMBL_Ref = {{ebicite|changed|EBI}} |
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| ChEMBL = 2104825 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = |
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| DrugBank = |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 11313 |
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| ChemSpiderID = 11313 |
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<!--Chemical data--> |
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<!--Chemical data--> |
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| chemical_formula = 8-Bromotheophylline: C<sub>7</sub>H<sub>7</sub>BrN<sub>4</sub>O<sub>2</sub><br />2-Amino-2-methyl-1-propanol: C<sub>4</sub>H<sub>11</sub>NO |
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| chemical_formula = 8-Bromotheophylline: C<sub>7</sub>H<sub>7</sub>BrN<sub>4</sub>O<sub>2</sub><br />2-Amino-2-methyl-1-propanol: C<sub>4</sub>H<sub>11</sub>NO |
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| molecular_weight = 348.20 |
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| molecular_weight = 348.20 |
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| molecular_weight_comment = g/mol |
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| smiles = O=C2N(c1nc(Br)nc1C(=O)N2C)C.OCC(N)(C)C |
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| smiles = Cn2c(=O)c1c(Br)nc1n(C)c2=O.NC(C)(C)CO |
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| InChI = 1/C7H7BrN4O2.C4H11NO/c1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14;1-4(2,5)3-6/h1-2H3,(H,9,10);6H,3,5H2,1-2H3 |
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| InChIKey = ATOTUUBRFJHZQG-UHFFFAOYAD |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C7H7BrN4O2.C4H11NO/c1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14;1-4(2,5)3-6/h1-2H3,(H,9,10);6H,3,5H2,1-2H3 |
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| StdInChI = 1S/C7H7BrN4O2.C4H11NO/c1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14;1-4(2,5)3-6/h1-2H3,(H,9,10);6H,3,5H2,1-2H3 |
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'''Pamabrom''' (trade name '''Diurex''') is a ] product included in retail ]s available in over-the-counter medications. The active diuretic ingredient in pamabrom is ]. |
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'''Pamabrom''', manufactured by ], is a product included in retail ]s available in over-the-counter medications. The active diuretic ingredient in pamabrom is ] and it also contains ]. |
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Pamabrom is available in combination with ] (paracetamol) for various conditions such as back pain and menstrual relief.<ref name="pmid15013925">{{cite journal | vauthors = Di Girolamo G, Sánchez AJ, De Los Santos AR, González CD | title = Is acetaminophen, and its combination with pamabrom, an effective therapeutic option in primary dysmenorrhoea? | journal = Expert Opinion on Pharmacotherapy | volume = 5 | issue = 3 | pages = 561–70 | date = March 2004 | pmid = 15013925 | doi = 10.1517/14656566.5.3.561 | s2cid = 26876035 }}</ref> The acetaminophen helps reduce ] pains and the pamabrom reduces associated bloating. The combination is available in a number of products from various brands under different names. The dosages are essentially the same for each brand, including ] store varieties. |
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A ] is also used to reduce edema (fluid buildup) in the body. Edema can cause swelling of the extremities, such as in the hands and feet. Edema can make it harder for the heart to work properly, and it can be related to ]. |
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Pamabrom is available in combination with ] (paracetamol) for various conditions such as back pain and menstrual relief. The acetaminophen helps reduce ] pains and the pamabrom reduces associated bloating. The combination is available in a number of products from various brands under different names. The dosages are essentially the same for each brand, including generic drug store varieties. |
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==References== |
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==References== |
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{{reflist}} |
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{{Reflist}} |
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== External links == |
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== External links == |
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* {{Webarchive|url=https://web.archive.org/web/20080312211246/http://www.medicinenet.com/script/main/art.asp?articlekey=52104 |date=2008-03-12 }} |
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