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{{Unreferenced stub|auto=yes|date=December 2009}} |
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{{Chembox |
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| verifiedrevid = 402031007 |
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| ImageFile = Phosphatidylinositol-3-phosphate.jpg |
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| ImageFile = Phosphatidylinositol-3-phosphate.svg |
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| IUPACName = |
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| IUPACName = |
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| OtherNames = sn-1-stearoyl-2-arachidonoyl phosphatidylinositol 3-phosphate |
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| OtherNames = sn-1-stearoyl-2-arachidonoyl phosphatidylinositol 3-phosphate |
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| Section1 = {{Chembox Identifiers |
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|Section1={{Chembox Identifiers |
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| Abbreviations = PtdIns3''P'' <br/> PtdIns(3)''P'' <br/> PI3P <br/> PI(3)P |
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| CASNo_Ref = {{cascite|correct|??}} |
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| CASNo = |
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| PubChem = 6857403 |
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| PubChem = 6857403 |
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| SMILES = }} |
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| Section2 = {{Chembox Properties |
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|Section2={{Chembox Properties |
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| Formula = C<sub>11</sub>H<sub>20</sub>O<sub>16</sub>P<sub>2</sub> |
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| Formula = C<sub>11</sub>H<sub>20</sub>O<sub>16</sub>P<sub>2</sub> |
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| MolarMass = 470.214 g/mol, neutral with fatty acid composition - 18:0, 20:4 |
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| MolarMass = 470.214 g/mol, neutral with fatty acid composition - 18:0, 20:4 |
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| Section3 = {{Chembox Hazards |
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|Section3={{Chembox Hazards |
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'''Phosphatidylinositol 3-phosphate''' (PtdIns3''P'' or PI3P) is a ] found in ] that helps to recruit a range of proteins, many of which are involved in protein trafficking, to the membranes. It is the product of both the class II and III ] (PI 3-kinases) activity on ]. |
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'''Phosphatidylinositol 3-phosphate''' ('''PI3P''') is a ] found in ] that helps to recruit a range of proteins, many of which are involved in protein trafficking, to the membranes. It is the product of both the class II and III ] (PI 3-kinases) activity on ].<ref>{{cite journal | vauthors = Gillooly DJ, Simonsen A, Stenmark H | title = Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteins | journal = The Biochemical Journal | volume = 355 | issue = Pt 2 | pages = 249–58 | date = April 2001 | pmid = 11284710 | pmc = 1221734 | doi = 10.1042/0264-6021:3550249 }}</ref> |
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PtdIns3''P'' is dephophosphorylated by the ] family of ]s, on the D3 position of the inositol ring, and can be converted to ] by the lipid kinase ]. |
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PtdIns3''P'' is dephosphorylated by the ] family of ]s, on the D3 position of the inositol ring, and can be converted to ] by the lipid kinase ].<ref>{{cite journal | vauthors = De Craene JO, Bertazzi DL, Bär S, Friant S | title = Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways | journal = International Journal of Molecular Sciences | volume = 18 | issue = 3 | pages = 634 | date = March 2017 | pmid = 28294977 | pmc = 5372647 | doi = 10.3390/ijms18030634 | doi-access = free }}</ref> |
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Both ] domains and ]s – found in proteins such as ], ], and ] – bind to PtdIns3''P''. |
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Both ] domains and ]s – found in proteins such as ], ], and ] – bind to PtdIns3''P''.<ref>{{cite journal | vauthors = Stenmark H, Aasland R, Driscoll PC | title = The phosphatidylinositol 3-phosphate-binding FYVE finger | journal = FEBS Letters | volume = 513 | issue = 1 | pages = 77–84 | date = February 2002 | pmid = 11911884 | doi = 10.1016/s0014-5793(01)03308-7 | doi-access = | bibcode = 2002FEBSL.513...77S }}</ref> |
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The majority of PtdIns3''P'' appears to be constitutively synthesised by the ], Vps34, at endocytic membranes. ] also appear to synthesise PtdIns3''P'', their activity however appears to be regulated by a range of stimuli, including growth factors. This suggests that specific pools of PtdIns3''P'' may be synthesised upon cell stimulation. |
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The majority of PtdIns3''P'' appears to be constitutively synthesised by the ], ] (Vps34), at endocytic membranes. ] also appear to synthesise PtdIns3''P'', their activity however appears to be regulated by a range of stimuli, including growth factors. This suggests that specific pools of PtdIns3''P'' may be synthesised upon cell stimulation. |
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== See also == |
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* ] |
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== References == |
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{{reflist}} |
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{{Phospholipids}} |
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{{Phospholipids}} |
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{{DEFAULTSORT:Phosphatidylinositol 3-Phosphate}} |
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{{DEFAULTSORT:Phosphatidylinositol 3-Phosphate}} |
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] |
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] |
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] |
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{{Transferase-stub}} |
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{{Transferase-stub}} |
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] |
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