| Revision as of 13:29, 5 December 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{drugbox}} taken from revid 458184665 of page Poly_ICLC for the Chem/Drugbox validation project (updated: ''). |
Latest revision as of 08:22, 23 September 2024 edit Graeme Bartlett (talk | contribs)Administrators249,716 edits more ids |
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{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid of page ] with values updated to verified values.}} |
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{{Drugbox |
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{{Drugbox |
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| verifiedrevid = 464209114 |
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| Verifiedfields = changed |
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| verifiedrevid = 447996086 |
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| IUPAC_name = |
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| IUPAC_name = |
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| image = |
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| image = |
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| type = combo |
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| component1 = Carboxymethylcellulose |
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<!--Clinical data--> |
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| class1 = |
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| component2 = Polyinosinic-polycytidylic acid |
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| class2 = |
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| component3 = Poly-L-lysine |
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| class3 = |
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<!-- Clinical data --> |
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| tradename = |
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| tradename = |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| legal_status = |
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| legal_status = |
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| routes_of_administration = |
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| routes_of_administration = |
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<!-- Pharmacokinetic data --> |
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<!--Pharmacokinetic data--> |
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| bioavailability = |
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| bioavailability = |
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| protein_bound = |
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| protein_bound = |
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| elimination_half-life = |
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| elimination_half-life = |
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| excretion = |
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| excretion = |
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<!-- Identifiers --> |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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<!--Identifiers--> |
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| ChemSpiderID = none |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| CAS_number_Ref = {{cascite|changed|UNII}} |
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| ChemSpiderID = NA |
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| CAS_number = 59789-29-6 |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = |
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| ATC_prefix = L03 |
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| ATC_prefix = L03 |
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| ATC_suffix = AX08 |
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| ATC_suffix = AX08 |
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| PubChem = |
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| PubChem = |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = |
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| DrugBank = DB17293 |
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| UNII = 7KYP9TKT70 |
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<!--Chemical data--> |
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<!-- Chemical data --> |
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| chemical_formula = |
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| chemical_formula = |
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| molecular_weight = |
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'''Poly ICLC''' is an ]. It is ] (poly I:C) mixed with the stabilizers ] and ].<ref name="pmid17295916"/> It is under trial for use in cancer.<ref>{{cite web |title=Intervention Dynamic Trial Listing Page |url=https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/poly-iclc |website=National Cancer Institute |language=en |date=13 June 2017}}</ref> |
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Poly I:C is a ligand for ], which usually triggers on the structurally similar ] present in some viruses.<ref name="pmid17295916">{{cite journal |vauthors=Zhu X, Nishimura F, Sasaki K, etal |title=Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models |journal=Journal of Translational Medicine |volume=5 |pages=10 |year=2007 |pmid=17295916 |doi=10.1186/1479-5876-5-10 |pmc=1802742 |doi-access=free }}</ref> |
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==References== |
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{{reflist}} |
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==External links== |
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* National Cancer Institute: |
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{{Immunostimulants}} |
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] |
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] |
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{{antineoplastic-drug-stub}} |