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Revision as of 13:44, 5 December 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{drugbox}} taken from revid 457647503 of page Porfimer_sodium for the Chem/Drugbox validation project (updated: 'DrugBank', 'UNII', 'ChEMBL', 'CAS_number').  Latest revision as of 17:40, 11 November 2024 edit Cbare (talk | contribs)103 editsmNo edit summary 
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{{short description|Pharmaceutical drug}}
{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid of page ] with values updated to verified values.}}
{{Drugbox {{Drugbox
| Verifiedfields = changed | Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 400857189 | verifiedrevid = 464210732
| IUPAC_name = | IUPAC_name =
| image = Porfimer Sodium.png | image = Porfimer Sodium.png
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<!--Clinical data--> <!--Clinical data-->
| tradename = | tradename = Photofrin
| Drugs.com = {{drugs.com|CDI|porfimer_sodium}} | Drugs.com = {{drugs.com|CDI|porfimer_sodium}}
| licence_EU = Photobarr | licence_EU = yes
| licence_US = Photofrin | licence_US = Photofrin
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
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<!--Identifiers--> <!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}} | CAS_number_Ref = {{cascite|correct|CAS}}
| CAS_number = <!-- blanked - oldvalue: 97067-70-4 --> | CAS_number = 87806-31-3
| index2_label = ethyl ether
⚫ | CAS_supplemental = {{CAS|87806-31-3}}
| CAS_number2_Ref = {{cascite|correct|CAS}}
| CAS_number2 = 97067-70-4
| UNII2_Ref = {{fdacite|correct|FDA}}
| UNII2 = 625J2HS54G
⚫ | CAS_supplemental =
| ATC_prefix = L01 | ATC_prefix = L01
| ATC_suffix = XD01 | ATC_suffix = XD01
| ATC_supplemental = | ATC_supplemental =
| PubChem = 57166 | PubChem = 57166
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = <!-- blanked - oldvalue: APRD00078 --> | DrugBank = DB00707
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 10482283 | ChemSpiderID = 10482283
| UNII_Ref = {{fdacite|changed|FDA}} | UNII_Ref = {{fdacite|changed|FDA}}
| UNII = <!-- blanked - oldvalue: Y3834SIK5F --> | UNII = Y3834SIK5F
| ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = <!-- blanked - oldvalue: 1201707 --> | ChEMBL = 1201707

⚫ | C=68 | H=74 | N=8 | O=11 (for n=0)
<!--Chemical data-->
⚫ | C=68 | H=74 | N=8 | O=11
| chemical_formula_comment = (for n=0)
| molecular_weight = 1179.36 g/mol (for n=0) | molecular_weight = 1179.36 g/mol (for n=0)
| smiles = .OC(=O)CC\C2=C(/C)c1cc%10nc(cc4nc(cc3nc(cc2n1)c(CCC(O)=O)c3C)/C(=C4/C)C(C)OC(C)c9c5nc(cc8nc(cc7nc(cc6nc(c5)C(\C)=C6\C(C)O)c(C)c7CCC(O)=O)C(\CCC(O)=O)=C8\C)c9C)c(C(C)O)c%10C | smiles = .CC(O)C1=C(C)C=2C=C5NC(=CC4=NC(=CC=3NC(C=C1N=2)=C(C)C=3CCC(O)=O)C(CCC(O)=O)=C4C)C(C)=C5C(C)OC(C)C6=C(C)C=7C=C%10NC(=CC9=NC(=CC=8NC(C=C6N=7)=C(C)C=8CCC(O)=O)C(CCC(O)=O)=C9C)C(C)=C%10C(C)O
| InChI = 1/C68H74N8O11.Na
| InChIKey = CGQHMICGJYKFFJ-ZLJVSRBABP
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C68H74N8O11.Na/c1-29-41(13-17-61(79)80)53-28-56-44(16-20-64(85)86)32(4)48(72-56)24-59-68(36(8)52(76-59)25-58-65(37(9)77)33(5)49(73-58)21-45(29)69-53)40(12)87-39(11)67-35(7)50-22-46-30(2)42(14-18-62(81)82)54(70-46)27-55-43(15-19-63(83)84)31(3)47(71-55)23-57-66(38(10)78)34(6)51(74-57)26-60(67)75-50;/h21-28,37-40,71-73,75,77-78H,13-20H2,1-12H3,(H,79,80)(H,81,82)(H,83,84)(H,85,86);/q;+1/b45-21-,46-22-,47-23-,48-24-,49-21-,50-22-,51-26-,52-25-,53-28-,54-27-,55-27-,56-28-,57-23-,58-25-,59-24-,60-26-; | StdInChI = 1S/C68H74N8O11.Na/c1-29-41(13-17-61(79)80)53-28-56-44(16-20-64(85)86)32(4)48(72-56)24-59-68(36(8)52(76-59)25-58-65(37(9)77)33(5)49(73-58)21-45(29)69-53)40(12)87-39(11)67-35(7)50-22-46-30(2)42(14-18-62(81)82)54(70-46)27-55-43(15-19-63(83)84)31(3)47(71-55)23-57-66(38(10)78)34(6)51(74-57)26-60(67)75-50;/h21-28,37-40,71-73,75,77-78H,13-20H2,1-12H3,(H,79,80)(H,81,82)(H,83,84)(H,85,86);/q;+1/b45-21-,46-22-,47-23-,48-24-,49-21-,50-22-,51-26-,52-25-,53-28-,54-27-,55-27-,56-28-,57-23-,58-25-,59-24-,60-26-;
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| StdInChIKey = CGQHMICGJYKFFJ-ZLJVSRBASA-N | StdInChIKey = CGQHMICGJYKFFJ-ZLJVSRBASA-N
}} }}
'''Porfimer sodium''', sold as '''Photofrin''', is a ] used in ] and ] and for ] of obstructing endobronchial ] and obstructing ].

Porfimer is a mixture of ] formed by ether and ester linkages of up to eight ] units.<ref>{{cite web |url=http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020451s019lbl.pdf |title=Porfimer injection Prescribing information}}</ref> In practice, a red light source emitting at 630&nbsp;nm is used to excite the Porfimer oligomers.<ref name="Usuda_2006">{{cite journal | vauthors = Usuda J, Kato H, Okunaka T, Furukawa K, Tsutsui H, Yamada K, Suga Y, Honda H, Nagatsuka Y, Ohira T, Tsuboi M, Hirano T | display-authors = 6 | title = Photodynamic therapy (PDT) for lung cancers | journal = Journal of Thoracic Oncology | volume = 1 | issue = 5 | pages = 489–93 | date = June 2006 | pmid = 17409904 | doi = 10.1016/S1556-0864(15)31616-6 | doi-access = free }}</ref>

Porfimer is ] Derivative (HpD) (See ]).

==Approvals and indications==
It was approved in Canada in 1993 for the treatment of ].<ref name = "Usuda_2006"/>
It was approved in Japan in 1994 (for early stage lung cancer?).<ref name = "Usuda_2006"/>
It was approved by the ] in December 1995 for ], and in 1998, it was approved for the treatment of early ].<ref name = "Usuda_2006"/>

In August 2003 the FDA approved its use for ].<ref>{{cite web |url=http://www.accessdata.fda.gov/psn/printer-full.cfm?id=24 |title=FDA Patient Safety News: Show #20, October 2003 |date=October 2003 |access-date=2009-08-17}}</ref>

==References==
{{Reflist}}

==External links==
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{{Chemotherapeutic agents}}

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