| Revision as of 13:49, 5 December 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{chembox}} taken from revid 454759247 of page Potassium_citrate for the Chem/Drugbox validation project (updated: 'ChEMBL'). |
Latest revision as of 22:58, 4 September 2024 edit MrOllie (talk | contribs)Extended confirmed users, Pending changes reviewers, Rollbackers237,037 edits Reverted 1 edit by Joe5088 (talk): SpamTags: Twinkle Undo |
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{{ambox | text = This page contains a copy of the infobox ({{tl|chembox}}) taken from revid of page ] with values updated to verified values.}} |
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{{chembox |
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| ImageFile = Kaliumcitrat V2.svg |
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| verifiedrevid = 400857823 |
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| ImageSize = 300px |
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|ImageFile=Potassium citrate.svg |
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|IUPACName=tripotassium citrate |
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| verifiedrevid = 464211279 |
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|OtherNames= |
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| PIN = Tripotassium 2-hydroxypropane-1,2,3-tricarboxylate |
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|Section1= {{Chembox Identifiers |
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| OtherNames = |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| Section1 = {{Chembox Identifiers |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 12775 |
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| ChemSpiderID = 12775 |
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| ChEMBL_Ref = {{ebicite|changed|EBI}} |
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| ChEMBL = <!-- blanked - oldvalue: 1200458 --> |
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| ChEMBL = 1200458 |
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| InChI = 1/C6H8O7.3K/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3 |
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| InChI = 1/C6H8O7.3K/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3 |
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| InChIKey = QEEAPRPFLLJWCF-DFZHHIFOAD |
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| InChIKey = QEEAPRPFLLJWCF-DFZHHIFOAD |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = QEEAPRPFLLJWCF-UHFFFAOYSA-K |
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| StdInChIKey = QEEAPRPFLLJWCF-UHFFFAOYSA-K |
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| CASNo_Ref = {{cascite|correct|CAS}} |
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| CASNo=866-84-2 |
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| CASNo =866-84-2 |
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| PubChem=13344 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| SMILES = ...O=C()CC(O)(C()=O)CC(=O) |
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| UNII = 86R1NVR0HW |
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| PubChem =13344 |
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| SMILES = ...O=C()CC(O)(C()=O)CC(=O) |
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|Section2= {{Chembox Properties |
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| Section2 = {{Chembox Properties |
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| Formula=C<sub>6</sub>H<sub>5</sub>K<sub>3</sub>O<sub>7</sub> |
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| Formula =K<sub>3</sub>C<sub>6</sub>H<sub>5</sub>O<sub>7</sub> |
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| MolarMass=306.395 g/mol |
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| MolarMass =306.395 g/mol |
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| Appearance= white powder <br> ] |
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| Appearance = white powder <br> ] |
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| Odor = odorless |
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| Odor = odorless |
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| Density= 1.98 g/cm<sup>3</sup> |
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| Density = 1.98 g/cm<sup>3</sup> |
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| MeltingPtC = 180 |
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| MeltingPt=180 °C<ref name="MSDS"></ref> |
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| MeltingPt_ref = <ref name="MSDS">{{Cite web |title=Potassium Citrate |url=http://hazard.com/msds/mf/baker/baker/files/p5675.htm |url-status=usurped |archive-url=https://web.archive.org/web/20170815200458/http://hazard.com/msds/mf/baker/baker/files/p5675.htm |archive-date=2017-08-15 |website=hazard.com}}</ref> |
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| BoilingPt=230 °C<ref name="MSDS"/> |
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| BoilingPtC = 230 |
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| Solubility= soluble |
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| BoilingPt_ref = <ref name="MSDS"/> |
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| SolubleOther = soluble in ] <br> insoluble in ] (95%) |
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| Solubility = soluble |
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| SolubleOther = soluble in ] <br> insoluble in ] (95%) |
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| pKa = 8.5 |
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|Section3= {{Chembox Hazards |
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| Section6 = {{Chembox Pharmacology |
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| ATCCode_prefix = A12 |
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| ATCCode_suffix = BA02 |
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| Section7 = {{Chembox Hazards |
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| LD50 = 170 mg/kg (IV, dog) |
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| LD50 = 170 mg/kg (IV, dog)<br/>5400mg/kg (oral, rat) |
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'''Potassium citrate''' (also known as '''tripotassium citrate''') is a ] ] of ] with the molecular formula K<sub>3</sub>C<sub>6</sub>H<sub>5</sub>O<sub>7</sub>. It is a white, ] crystalline powder. It is odorless with a ] taste. It contains 38.28% potassium by mass. In the monohydrate form, it is highly ] and ]. |
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As a ], potassium citrate is used to regulate acidity, and is known as ] E332. Medicinally, it may be used to control ]s derived from ] or ]. |
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In 2020, it was the 297th most commonly prescribed medication in the United States, with more than 1{{nbsp}}million prescriptions.<ref>{{cite web | title = The Top 300 of 2020 | url = https://clincalc.com/DrugStats/Top300Drugs.aspx | website = ClinCalc | access-date = 7 October 2022}}</ref><ref>{{cite web | title = Potassium Citrate - Drug Usage Statistics | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/PotassiumCitrate | access-date = 7 October 2022}}</ref> |
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==Synthesis== |
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Potassium citrate can be synthesized by the neutralization of ] which is achieved by the addition of ], ] or ] to it. The solution can then be filtered and the solvent can be evaporated till granulation. |
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==Uses== |
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Potassium citrate is rapidly absorbed when given by mouth, and is excreted in the urine.<ref></ref> Since it is an alkaline salt, it is effective in reducing the pain and frequency of ] when these are caused by highly acidic urine.<ref></ref> It is used for this purpose in dogs and cats, but is chiefly employed as a non-irritating ]. |
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Potassium citrate is an effective way to treat/manage ],{{medcn|date=May 2013}} if the patient is ]. |
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It is widely used to treat urinary calculi (]), and is often used by patients with ].{{medcn|date=May 2013}} A systematic review showed a significant reduction in the incidence of stone formation ] 0.26, 95% CI 0.10 to 0.68.<ref>{{cite journal |last1=Phillips |first1=Rebecca |last2=Hanchanale |first2=Vishwanath S |last3=Myatt |first3=Andy |last4=Somani |first4=Bhaskar |last5=Nabi |first5=Ghulam |last6=Biyani |first6=C Shekhar |title=Citrate salts for preventing and treating calcium containing kidney stones in adults |journal=Cochrane Database of Systematic Reviews |date=6 October 2015 |volume=2015 |issue=10 |pages=CD010057 |doi=10.1002/14651858.CD010057.pub2 |pmid=26439475 |pmc=9578669 }}</ref> |
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It is also used as an ] in the treatment of mild urinary tract infections, such as ].<ref>{{Cite web |publisher = patient.info|url = http://patient.info/medicine/potassium-citrate-for-cystitis|title = Potassium citrate for cystitis}}</ref> |
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It is also used in many ] as a ].<ref>{{Cite web|url=https://www.livestrong.com/article/314839-soft-drinks-with-potassium-citrate/|title = Soft Drinks with Potassium Citrate}}</ref> |
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Frequently used in an aqueous solution with other potassium salts, it is a ] that is particularly useful against kitchen fires.<ref>{{Cite web |last=Fire |first=Impact |title=What is a Class K Fire Extinguisher Used For? |url=https://resources.impactfireservices.com/what-is-a-class-k-fire-extinguisher-used-for |access-date=2022-08-18 |website=resources.impactfireservices.com |language=en-us}}</ref> Its alkaline pH encourages ] to insulate the fuel from oxidizing air, and the ] ] absorbs heat energy to reduce temperatures.<ref>{{cite patent |
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| country = US |
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| number = 5945025A |
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| status = Fire extinguishing composition and method for fire extinguishing |
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| inventor = James A. Cunningham |
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}}</ref><ref>Xiaofang Wangy ''et al'' 2019 ''IOP Conf. Ser.: Mater. Sci. Eng.'' '''490''' 022047</ref> |
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==Administration== |
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Potassium citrate liquid is usually administered by mouth in a diluted aqueous solution, because of its somewhat caustic effect on the stomach lining, and the potential for other mild health hazards. Pill tablets also exist in normal, and extended-release formulations. |
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==References== |
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{{reflist}} |
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==External links== |
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*Tanner, G.A. . ''Journal of the American Society of Nephrology''. Retrieved December 17, 2016. |
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{{Mineral supplements}} |
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