| Revision as of 09:17, 31 October 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'CAS_number').← Previous edit |
Latest revision as of 20:47, 1 December 2023 edit undoBuidhe (talk | contribs)Autopatrolled, Extended confirmed users, Page movers, File movers, Mass message senders, New page reviewers, Pending changes reviewers, Template editors136,063 editsm Moving from Category:Experimental drugs to Category:Experimental monoclonal antibodies using Cat-a-lot |
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{{Short description|Monoclonal antibody}} |
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{{Drugbox |
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{{Drugbox |
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| Verifiedfields = changed |
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| Verifiedfields = changed |
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| verifiedrevid = 450330682 |
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| verifiedrevid = 464214206 |
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| image = |
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| image = |
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<!-- Monoclonal antibody data --> |
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<!--Monoclonal antibody data--> |
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| type = mab |
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| type = mab |
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| mab_type = mab |
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| mab_type = mab |
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| source = xi/o |
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| source = xi/o |
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| target = ] |
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| target = ] |
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<!-- Clinical data --> |
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<!--Clinical data--> |
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| tradename = |
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| tradename = |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category = |
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| pregnancy_category = |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled --> |
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| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> |
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| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> |
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| routes_of_administration = |
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| routes_of_administration = |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID = NA |
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| ChemSpiderID = none |
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<!-- Pharmacokinetic data --> |
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<!--Pharmacokinetic data--> |
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| bioavailability = |
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| bioavailability = |
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| protein_bound = |
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| protein_bound = |
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| metabolism = |
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| metabolism = |
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| elimination_half-life = |
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| elimination_half-life = |
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| excretion = |
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| excretion = |
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<!-- Identifiers --> |
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| CAS_number_Ref = {{cascite|changed|CAS}} |
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<!--Identifiers--> |
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| CAS_number = 147191-91-1 |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| CAS_number = <!-- blanked - oldvalue: 147191-91-1 --> |
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| UNII = TW5DE23BLM |
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| ATC_prefix = none |
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| ATC_prefix = none |
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| ATC_suffix = |
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| ATC_suffix = |
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| PubChem = |
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| PubChem = |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = |
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| DrugBank = |
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<!-- Chemical data --> |
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| chemical_formula = |
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<!--Chemical data--> |
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| chemical_formula = |
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| molecular_weight = |
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| molecular_weight = |
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}} |
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}} |
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'''Priliximab''' (cMT 412) is a human-mouse chimeric anti-CD4 ]. It has been tested on patients with ]<ref>{{cite journal |author=Stronkhorst A, Radema S, Yong S, Bijl H, ten Berge I, Tytgat G, van Deventer S |title=CD4 antibody treatment in patients with active Crohn's disease: a phase 1 dose finding study |journal=Gut |volume=40 |issue=3 |pages=320–7 |year=1997 |pmid=9135519 |pmc=1027080}}</ref> and ]<ref>{{cite journal |author=Llewellyn-Smith N, Lai M, Miller D, Rudge P, Thompson A, Cuzner M |title=Effects of anti-CD4 antibody treatment on lymphocyte subsets and stimulated tumor necrosis factor alpha production: a study of 29 multiple sclerosis patients entered into a clinical trial of cM-T412 |journal=Neurology |volume=48 |issue=4 |pages=810–6 |year=1997 |pmid=9109860}}</ref><ref>{{cite journal |author=van Oosten B, Lai M, Hodgkinson S, Barkhof F, Miller D, Moseley I, Thompson A, Rudge P, McDougall A, McLeod J, Adèr H, Polman C |title=Treatment of multiple sclerosis with the monoclonal anti-CD4 antibody cM-T412: results of a randomized, double-blind, placebo-controlled, MR-monitored phase II trial |journal=Neurology |volume=49 |issue=2 |pages=351–7 |year=1997 |pmid=9270561}}</ref> but has not yet received ] licencing. The patent belongs to the biotechnology company ]. |
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'''Priliximab''' (cMT 412) is a human-mouse chimeric anti-CD4 ]. It has been tested on patients with ]<ref>{{cite journal |vauthors=Stronkhorst A, Radema S, Yong S, Bijl H, ten Berge I, Tytgat G, van Deventer S |title=CD4 antibody treatment in patients with active Crohn's disease: a phase 1 dose finding study |journal=Gut |volume=40 |issue=3 |pages=320–7 |year=1997 |pmid=9135519 |pmc=1027080|doi=10.1136/gut.40.3.320 }}</ref> and ]<ref>{{cite journal |vauthors=Llewellyn-Smith N, Lai M, Miller D, Rudge P, Thompson A, Cuzner M |title=Effects of anti-CD4 antibody treatment on lymphocyte subsets and stimulated tumor necrosis factor alpha production: a study of 29 multiple sclerosis patients entered into a clinical trial of cM-T412 |journal=Neurology |volume=48 |issue=4 |pages=810–6 |year=1997 |pmid=9109860 |doi=10.1212/wnl.48.4.810|s2cid=9938490 }}</ref><ref>{{cite journal |vauthors=van Oosten B, Lai M, Hodgkinson S, Barkhof F, Miller D, Moseley I, Thompson A, Rudge P, McDougall A, McLeod J, Adèr HJ, Polman C |author11-link=Herman J. Adèr |title=Treatment of multiple sclerosis with the monoclonal anti-CD4 antibody cM-T412: results of a randomized, double-blind, placebo-controlled, MR-monitored phase II trial |journal=Neurology |volume=49 |issue=2 |pages=351–7 |year=1997 |pmid=9270561 |doi=10.1212/wnl.49.2.351|s2cid=8294890 }}</ref> but has not yet received ] licensing. The patent belongs to the biotechnology company ]. |
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==References== |
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==References== |
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{{Monoclonals for immune system}} |
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{{Monoclonals for immune system}} |
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{{monoclonal-antibody-stub}} |
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{{monoclonal-antibody-stub}} |
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{{antineoplastic-drug-stub}} |
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{{antineoplastic-drug-stub}} |