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{{chembox {{chembox
| Verifiedfields = changed
⚫ | verifiedrevid = 385631746
| Watchedfields = changed
|ImageFile=Proamanullin structure.png
⚫ | verifiedrevid = 443950451
|ImageSize=200px
|ImageFile1=Proamanullin 3d chemical structure.png | ImageFile=Proamanullin structure.png
|ImageSize1=200px | ImageSize=200px
| ImageFile1=
⚫ |IUPACName=
| ImageSize1=
⚫ |OtherNames=2-L-Proline-3-isoleucine-alpha-amanitin
⚫ | IUPACName=
⚫ |Section1= {{Chembox Identifiers
⚫ | OtherNames=2-L-Proline-3-isoleucine-alpha-amanitin
⚫ | CASNo=54532-46-6
⚫ |Section1={{Chembox Identifiers
⚫ | PubChem=171350
| CASNo_Ref = {{cascite|correct|??}}
⚫ | SMILES=O=C(NCC(N(C(NCC(N(C3)C(N(CC(N)=O)C(N54CCC5)=O)=O)=O)=O)()(C)CC)=O)(CC1=C(S3=O)NC2=C1C=CC(O)=C2)NC(((C)CC)()N4=O)=O
⚫ | CASNo=54532-46-6
⚫ | PubChem=171350
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 48308194
⚫ | SMILES=O=C(NCC(N(C(NCC(N(C3)C(N(CC(N)=O)C(N54CCC5)=O)=O)=O)=O)()(C)CC)=O)(CC1=C(S3=O)NC2=C1C=CC(O)=C2)NC(((C)CC)()N4=O)=O
| InChI = 1/C39H54N10O11S/c1-5-18(3)31-36(57)42-15-29(52)43-26-17-61(60)38-22(21-10-9-20(50)12-23(21)46-38)13-24(33(54)41-16-30(53)47-31)44-37(58)32(19(4)6-2)48-35(56)27-8-7-11-49(27)39(59)25(14-28(40)51)45-34(26)55/h9-10,12,18-19,24-27,31-32,46,50H,5-8,11,13-17H2,1-4H3,(H2,40,51)(H,41,54)(H,42,57)(H,43,52)(H,44,58)(H,45,55)(H,47,53)(H,48,56)/t18-,19-,24-,25-,26-,27-,31-,32-,61?/m0/s1
| InChIKey = CTYHFRWAIRSHQT-YRDOMICZBU
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C39H54N10O11S/c1-5-18(3)31-36(57)42-15-29(52)43-26-17-61(60)38-22(21-10-9-20(50)12-23(21)46-38)13-24(33(54)41-16-30(53)47-31)44-37(58)32(19(4)6-2)48-35(56)27-8-7-11-49(27)39(59)25(14-28(40)51)45-34(26)55/h9-10,12,18-19,24-27,31-32,46,50H,5-8,11,13-17H2,1-4H3,(H2,40,51)(H,41,54)(H,42,57)(H,43,52)(H,44,58)(H,45,55)(H,47,53)(H,48,56)/t18-,19-,24-,25-,26-,27-,31-,32-,61?/m0/s1
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = CTYHFRWAIRSHQT-YRDOMICZSA-N
}} }}
|Section2= {{Chembox Properties |Section2={{Chembox Properties
| Formula=C<sub>39</sub>H<sub>54</sub>N<sub>10</sub>O<sub>11</sub>S | Formula=C<sub>39</sub>H<sub>54</sub>N<sub>10</sub>O<sub>11</sub>S
| MolarMass=870.97 g/mol | MolarMass=870.97 g/mol
| Appearance=Colorless, odorless | Appearance=Colorless, odorless
| Density= | Density=
| MeltingPt= | MeltingPt=
| BoilingPt= | BoilingPt=
| Solubility= | Solubility=
}} }}
|Section3= {{Chembox Hazards |Section3={{Chembox Hazards
| MainHazards= | MainHazards=
| FlashPt= | FlashPt=
| AutoignitionPt =
| Autoignition=
}} }}
}} }}


'''Promanullin''' is a ] ]. It is an ], all of which are found in several members of the '']'' genus of ]s. '''Promanullin''' is a ] ]. It is an ], all of which are found in the ] genus '']''.


==Toxicology== ==Toxicology==


Like other ], proamanullin is an inhibitor of ]. Promanullin has a specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing ] of ]s (liver cells).<ref>{{cite journal |author=Cochet-Meilhac M, Chambon P |title=Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins |journal=Biochim. Biophys. Acta |volume=353 |issue=2 |pages=160–84 |year=1974 |month=June |pmid=4601749 |doi= |url=}}</ref> Like other ], proamanullin is an inhibitor of ]. Promanullin has a specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing ] of ]s (liver cells).<ref>{{cite journal |vauthors=Cochet-Meilhac M, Chambon P |title=Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins |journal=Biochim. Biophys. Acta |volume=353 |issue=2 |pages=160–84 |date=June 1974 |pmid=4601749 |doi= 10.1016/0005-2787(74)90182-8}}</ref>

⚫ ==See also==
⚫ *]


==References== ==References==
{{reflist}} {{reflist}}

⚫ ==See also==
⚫ *]


==External links== ==External links==
* * {{Webarchive|url=https://web.archive.org/web/20090113180522/http://dohs.ors.od.nih.gov/pdf/Amatoxins%20REVISED.pdf |date=2009-01-13 }}


{{Poisonous Amanitas}} {{Poisonous Amanitas}}
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