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Revision as of 10:49, 16 February 2012 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{chembox}} taken from revid 477018197 of page Sodium_lactate for the Chem/Drugbox validation project (updated: '').		Latest revision as of 08:55, 22 December 2024 edit Whywhenwhohow (talk | contribs)Autopatrolled, Extended confirmed users, Pending changes reviewers49,153 editsm script-assisted date audit and style fixes per MOS:NUM
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			{{Use dmy dates|date=December 2024}}
	{{ambox | text = This page contains a copy of the infobox ({{tl|chembox}}) taken from revid of page ] with values updated to verified values.}}
			{{cs1 config|name-list-style=vanc}}
	{{chembox		{{chembox
			| Verifiedfields = changed
⚫	| verifiedrevid = 476992351
			| Watchedfields = changed
⚫	|ImageFile=Sodium lactate.png
		⚫	| verifiedrevid = 477163355
⚫	|ImageSize=180px
		⚫	| ImageFile = Sodium lactate.png
⚫	|ImageFileL1=Lactate-3D-balls.png
		⚫	| ImageSize = 180px
⚫	|ImageSizeL1=150px
		⚫	| ImageFileL1 = Lactate-3D-balls.png
⚫	|ImageNameL1=Ball-and-stick model of the lactate anion
		⚫	| ImageSizeL1 = 150px
⚫	|ImageFileR1=Sodium-3D.png
		⚫	| ImageNameL1 = Ball-and-stick model of the lactate anion
	|ImageSizeR1=90px
		⚫	| ImageFileR1 = Sodium-3D.png
	|ImageNameR1=The sodium cation		| ImageNameR1 = The sodium cation
	|IUPACName=Sodium 2-hydroxypropanoate		| PIN = Sodium 2-hydroxypropanoate
⚫	|OtherNames=Sodium DL-lactate; Lactic acid sodium salt; E325
			| OtherNames = {{Unbulleted list
			| Sodium {{small|DL}}-lactate
		⚫	| Lactic acid sodium salt
			| E325
			}}
	|Section1={{Chembox Identifiers		|Section1={{Chembox Identifiers
	| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}		| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
	| ChemSpiderID = 6049		| ChemSpiderID = 6049
	| InChI = 1/C3H6O3.Na/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);/q;+1/p-1		| InChI = 1/C3H6O3.Na/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);/q;+1/p-1
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	| StdInChIKey = NGSFWBMYFKHRBD-UHFFFAOYSA-M		| StdInChIKey = NGSFWBMYFKHRBD-UHFFFAOYSA-M
	| CASNo_Ref = {{cascite|correct|CAS}}		| CASNo_Ref = {{cascite|correct|CAS}}
	| CASNo=72-17-3		| CASNo = 72-17-3
			| UNII_Ref = {{fdacite|correct|FDA}}
			| UNII = TU7HW0W0QT
			| ChEBI_Ref = {{ebicite|changed|EBI}}
			| ChEBI = 75228
	| ChEMBL_Ref = {{ebicite|correct|EBI}}		| ChEMBL_Ref = {{ebicite|correct|EBI}}
	| ChEMBL = 1357		| ChEMBL = 1357
	| PubChem = 6286		| PubChem = 6286
	| SMILES = .C(=O)C(O)C		| SMILES = .C(=O)C(O)C
	}}		}}
	|Section2={{Chembox Properties		|Section2={{Chembox Properties
	| C=3|H=5|Na=1|O=3		| C=3 | H=5 | Na=1 | O=3
	| MolarMass=112.06&nbsp;g/mol<ref name="chemblink.com">, chemblink.com</ref>		| MolarMass =112.06&nbsp;g/mol<ref name="chemblink.com"> {{Webarchive|url=https://web.archive.org/web/20171201081057/https://www.chemblink.com/products/72-17-3.htm |date=1 December 2017 }}, chemblink.com</ref>
			| Appearance =White powder
	| Appearance=White powder<ref name=lotioncrafter>, lotioncrafter.com</ref>
	| Density=1.33&nbsp;g/mL,<ref name="chemblink.com" /> 1.31&nbsp;g/ml (60 % syrup)<ref name="chemblink.com" />		| Density =1.33&nbsp;g/mL,<ref name="chemblink.com" /> 1.31&nbsp;g/ml (60 % syrup)<ref name="chemblink.com" />
			| MeltingPtC = 161 to 162
	| MeltingPt=161–162 °C<ref name="lotioncrafter" /><br />
			| MeltingPt_notes = <br />
	17&nbsp;°C (60 % syrup)<ref name="MSDS"></ref>
			17&nbsp;°C (60 % syrup)<ref name="MSDS">{{cite web |url=http://msds.chem.ox.ac.uk/SO/sodium_lactate_syrup.html |title=Safety data for sodium lactate syrup |access-date=3 August 2011 |archive-date=5 March 2011 |archive-url=https://web.archive.org/web/20110305204703/http://msds.chem.ox.ac.uk/SO/sodium_lactate_syrup.html |url-status=dead }}</ref>
⚫	| BoilingPt=113 °C (60 % syrup)<ref name="MSDS" />
			| BoilingPtC = 113
	| Solubility=Miscible<ref name="chemblink.com" />
		⚫	| BoilingPt_notes = (60 % syrup)<ref name="MSDS" />
			| Solubility = > 1.5 g/mL
	}}		}}
	|Section3={{Chembox Hazards		|Section3={{Chembox Hazards
	| MainHazards=		| MainHazards =
	| FlashPt=		| FlashPt = < 25
			| AutoignitionPt =
	| Autoignition=
			| LD50 = 1000 mg/kg (intravenous, rat)<ref>{{cite web |url=https://chem.nlm.nih.gov/chemidplus/rn/72-17-3 |title=ChemIDplus - 72-17-3 - NGSFWBMYFKHRBD-UHFFFAOYSA-M - Sodium lactate &#91;USP:JAN&#93; - Similar structures search, synonyms, formulas, resource links, and other chemical information |access-date=10 August 2014 |archive-date=12 August 2014 |archive-url=https://web.archive.org/web/20140812231325/https://chem.nlm.nih.gov/chemidplus/rn/72-17-3 |url-status=dead }}</ref>
	}}		}}
	}}		}}
			'''Sodium lactate''' is the ] ] of ], and has a mild saline taste. It is produced by fermentation of a sugar source, such as ] or ], and then, by neutralizing the resulting lactic acid<ref name="Silberberg">{{cite book|last=Silberberg|first=Barrie|title=The Autism and ADHD Diet: A Step-by-Step Guide to Hope and Healing by Living Gluten Free and Casein Free (GFCF) and Other Interventions|url=https://archive.org/details/autismadhddietst00silb_103|url-access=limited|publisher=Sourcebooks, Inc.|year=2009|page=|isbn=978-1-4022-1845-3}}</ref> to create a ] having the formula NaC<sub>3</sub>H<sub>5</sub>O<sub>3</sub>.
			Sodium lactate, in the form of ], is used as a medication, and is included on the ].<ref name="WHO21st">{{cite book |title=World Health Organization model list of essential medicines: 21st list 2019 |vauthors=((World Health Organization)) |publisher=World Health Organization |year=2019 |location=Geneva |hdl=10665/325771 |id=WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO |author-link=World Health Organization |hdl-access=free}}</ref><ref name="WHO22nd">{{cite book |title=World Health Organization model list of essential medicines: 22nd list (2021) |vauthors=((World Health Organization)) |publisher=World Health Organization |year=2021 |location=Geneva |hdl=10665/345533 |id=WHO/MHP/HPS/EML/2021.02 |author-link=World Health Organization |hdl-access=free}}</ref>
			== Uses ==
			=== Food industry ===
			As a ], sodium lactate has the ] E325 and is naturally a liquid product, but also is available in powder form. It acts as a ], ], and bulking agent.<ref>{{cite web | url = http://www.dh.sa.gov.au/pehs/food/additive-code-numbers-nov06.pdf | title = Food Additive Code Numbers | author = | date = August 2006 | access-date = 16 August 2012 | publisher = ] | url-status = dead | archive-url = http://webarchive.loc.gov/all/20090521122611/http://www.dh.sa.gov.au/pehs/Food/additive-code-numbers-nov06.pdf | archive-date = 21 May 2009 }}</ref>
			Despite the similarity in name, sodium lactate itself is not chemically similar to ] (milk sugar), so need not be restricted by those with ].<ref name="Silberberg" /><ref name="Willitts">{{cite book |last=Willitts |first=Alice |url=https://archive.org/details/foodallergyyourc00will |title=Food allergy & your child |author2=Deborah Carter |publisher=Class Publishing Ltd |year=2007 |isbn=978-1-85959-186-4 |page= |quote=The following ingredients do not contain milk protein and need not be avoided by people allergic to milk: … Sodium lactate |url-access=limited}}</ref>
			=== Cosmetics and personal care products ===
			Sodium lactate is sometimes used in ] products and other similar items such as liquid soaps, as it is an effective ] and ].<ref>{{cite patent |country=US |number=4758599 |status=Patent |title = Clear, hydroalcoholic aftershave lotion which moisturizes, conditions, and prevents irritation |gdate=1988-07-19 |fdate=1988-06-04| invent1= Dawn C. Minetti}}</ref>
			=== Medical use ===
			Sodium lactate is used to treat arrhythmias caused by overdosing of ], as well as pressor ] which can cause ].<ref>{{cite book|last=Trevor|first=Anthony|author2=Bertram Katzung |author3=Susan Masters |title=Katzung & Trevor's Pharmacology Examination and Board Review|publisher=Go Dairy Free|year=2008|edition=8e|page=126|isbn=978-0-07-148869-3}}</ref>
			It can be given ] as a source of ] for preventing or controlling mild to moderate ] in patients with restricted oral intake (for sodium bicarbonate) whose oxidative processes are not seriously impaired. However, the use in ] is ].<ref>{{cite web | url = http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=2425 | title = Sodium Lactate (sodium lactate) Injection, Solution, Concentrate | author = Hospira, Inc. | date = November 2004 | accessdate = 16 August 2012 | publisher = U.S. ] | work = ] | archive-date = 4 January 2014 | archive-url = https://web.archive.org/web/20140104221601/http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=2425 | url-status = live }}</ref>
			Sodium lactate may ] in persons with existing ];<ref name="HollanderSimeon2003">{{cite book | author1 = Eric Hollander | author2 = Daphne Simeon | title = Concise Guide to Anxiety Disorders | url = https://books.google.com/books?id=qlXxu9D39xcC&pg=RA1-PA83 | accessdate = 13 May 2012 | year = 2003 | publisher = American Psychiatric Pub | isbn = 978-1-58562-080-7 | page = 1}}</ref> up to 72% of individuals with panic disorder experience a panic attack when administered sodium lactate intravenously. Sodium lactate may therefore also be used to confirm a diagnosis of panic disorder.<ref>{{cite book |last=Sadock |first=Benjamin J. |url=https://www.worldcat.org/oclc/190967531 |title=Kaplan & Sadock's concise textbook of clinical psychiatry |date=2008 |publisher=Wolters Kluwer/Lippincott Williams & Wilkins |others=Virginia A. Sadock, Benjamin J. Sadock |isbn=978-0-7817-8746-8 |edition=3rd |location=Philadelphia |oclc=190967531}}</ref>{{Rp|page=19}}
			In 2022, it was the 287th most commonly prescribed medication in the United States, with more than 500,000 prescriptions.<ref>{{cite web | title=The Top 300 of 2022 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=30 August 2024 | archive-date=30 August 2024 | archive-url=https://web.archive.org/web/20240830202410/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Lactate Drug Usage Statistics, United States, 2013 - 2022 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/Lactate | access-date = 30 August 2024 }}</ref>
			== Chemistry and biochemistry ==
			Sodium lactate is not chemically similar to ] (milk sugar).<ref name="Silberberg" /><ref name="Willitts" />
			=== Production ===
			In general, lactates such as sodium, ], and ] lactate are salts derived from the neutralization of lactic acid and most commercially used lactic acids are fermented from dairy-free products such as ], ]es, or ].<ref name="Fleming">{{cite book|last=Fleming|first=Alisa Marie|title=Go Dairy Free: The Guide and Cookbook for Milk Allergies, Lactose Intolerance, and Casein-free Living|publisher=Go Dairy Free|year=2008|page=|isbn=978-0-9791286-2-2|url=https://archive.org/details/godairyfreeguide0000flem/page/90}}</ref> ] or ] additionally may be used.<ref name="Silberberg" />
			In some rare instances, some lactic acid is fermented from dairy products such as ]<ref name="Silberberg" /> and ].<ref name="Fleming" /> Whey is made of up 6.5% solids of which 4.8% is solid lactose.<ref>{{cite book|last=Ranken|first=M. D.|author2=R. C. Kill |title=Food industries manual|url=https://archive.org/details/foodindustriesma00rank|url-access=limited|publisher=Springer|year=1997|page=|isbn=0-7514-0404-7}}</ref> Waste whey is infrequently used to produce lactic acid when the whey itself is produced as waste during the manufacture of certain dairy products.<ref>{{cite book|last=Inamdar|title=Biochemical Engineering: Principles And Concepts|publisher=PHI Learning Pvt. Ltd.|year=2009|page=254|isbn=978-81-203-3677-3}}</ref> Such dairy-type lactic acid generally goes back into dairy products, such as ] and ],<ref name="Fleming" /> rather than into non-dairy products. Moreover, although the lactic-acid starter culture to ferment corn or beets may contain milk,<ref name="Silberberg" /> sodium lactate does not contain milk protein and need not be restricted by someone avoiding milk or those with a milk allergy.<ref name="Silberberg" /><ref name="Willitts" />
			== References ==
			{{Reflist}}
			{{Portal bar|Medicine}}
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