| Revision as of 07:37, 29 August 2010 editحسن علي البط (talk | contribs)Extended confirmed users, Pending changes reviewers19,940 editsm Adding category Category:Bromides (using HotCat)← Previous edit |
Latest revision as of 03:33, 26 October 2024 edit undo76.174.0.57 (talk) Cats (source: https://en.wikipedia.org/Muscarinic_antagonist#Binding_affinities). |
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{{short description|Chemical compound}} |
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{{multiple issues| |
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{{context|date=April 2014}} |
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{{refimprove|date=July 2021}} |
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{{Drugbox |
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{{Drugbox |
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| Verifiedfields = changed |
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| IUPAC_name = 3-(di-2-thienylmethylene)-5-methoxy-1,1-dimethylpiperidinium bromide |
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| verifiedrevid = 381648256 |
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| image = TimepidiumBromide.png |
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| IUPAC_name = 3-(di-2-thienylmethylene)-5-methoxy-1,1-dimethylpiperidinium bromide |
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| CAS_number = 35035-05-3 |
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| image = TimepidiumBromide.png |
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| CAS_supplemental = |
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| ATC_prefix = A03 |
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<!--Clinical data--> |
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| ATC_suffix = AB19 |
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| ATC_supplemental = |
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| tradename = |
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| Drugs.com = {{drugs.com|international|timepidium-bromide}} |
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| PubChem = 160243 |
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| DrugBank = |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| chemical_formula = |
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| pregnancy_category = |
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| C=17 | H=22 | Br=1 | N=1 | O=1 | S=2 |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
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| molecular_weight = 400.39 g/mol |
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| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| smiles = C1(CC(CC(=C(C2=CC=CS2)C3=CC=CS3)C1)OC)C. |
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| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> |
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| bioavailability = |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| protein_bound = |
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| legal_status = Rx-only |
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| metabolism = |
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| elimination_half-life = |
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| excretion = |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category= |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
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| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_status = Rx-only |
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| routes_of_administration = SC, IM, IV |
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| routes_of_administration = SC, IM, IV |
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<!--Pharmacokinetic data--> |
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| bioavailability = |
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| protein_bound = |
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| metabolism = |
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| elimination_half-life = |
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| excretion = |
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<!--Identifiers--> |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 35035-05-3 |
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| ATC_prefix = A03 |
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| ATC_suffix = AB19 |
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| ATC_supplemental = |
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| PubChem = 160243 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = |
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| UNII_Ref = {{fdacite|changed|FDA}} |
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| UNII = 8R9E4766V4 |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID = 140841 |
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<!--Chemical data--> |
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| chemical_formula = |
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| C=17 | H=22 | Br=1 | N=1 | O=1 | S=2 |
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| smiles = C1(CC(CC(=C(C2=CC=CS2)C3=CC=CS3)C1)OC)C. |
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| StdInChI_Ref = {{stdinchicite|changed|chemspider}} |
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| StdInChI = 1S/C17H22NOS2.BrH/c1-18(2)11-13(10-14(12-18)19-3)17(15-6-4-8-20-15)16-7-5-9-21-16;/h4-9,14H,10-12H2,1-3H3;1H/q+1;/p-1 |
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| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} |
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| StdInChIKey = QTSXMEPZSHLZFF-UHFFFAOYSA-M |
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}} |
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}} |
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'''Timepidium bromide''' (]) is an ]. The quaternary nitrogen prevents it from crossing the ], so it is peripherally acting with no central side effects. |
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'''Timepidium bromide''' (]) is an ]. It is used in the symptomatic treatment of visceral spasms.<ref>{{Cite web|title=Timepidium bromide: Indication, Dosage, Side Effect, Precaution {{!}} MIMS Malaysia|url=https://www.mims.com/malaysia/drug/info/timepidium%20bromide?mtype=generic|access-date=2021-07-05|website=www.mims.com}}</ref> It is also used to relieve pain associated with various gastrointestinal disorders.<ref>{{Cite web|title=Timepidium Bromide Tablets 30mg SAWAI 100 Tablets｜Natural Pharmacy|url=https://www.mimaki-family-japan.com/item/detail?item_prefix=TF&item_code=005256&item_branch=001|access-date=2021-07-05|website=www.mimaki-family-japan.com}}</ref> The quaternary nitrogen prevents it from crossing the ], so it is peripherally acting with no central side effects. |
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The same compound ''sans'' the quaternary methyl group and the methoxy ether is called ].<ref name="Shah_2018">{{cite journal | vauthors = Shah R, Verma PK | title = Therapeutic importance of synthetic thiophene | journal = Chemistry Central Journal | volume = 12 | issue = 1 | pages = 137 | date = December 2018 | pmid = 30564984 | pmc = 6768136 | doi = 10.1186/s13065-018-0511-5 | doi-access = free }}</ref> |
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==References== |
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{{Reflist}} |
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{{Drugs for functional gastrointestinal disorders}} |
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{{Drugs for functional gastrointestinal disorders}} |
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{{Muscarinic acetylcholine receptor modulators}} |
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