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{{Short description|Combination drug}} |
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{{Unreferenced|date=February 2011}} |
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{{Use dmy dates|date=December 2024}} |
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{{cs1 config|name-list-style=vanc|display-authors=6}} |
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{{Drugbox |
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{{Drugbox |
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| verifiedrevid = 451334370 |
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| Watchedfields = changed |
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| verifiedrevid = 408681660 |
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| type = combo |
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| type = combo |
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| component1 = Trimethoprim |
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<!-- Combo data --> |
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| class1 = ] ] |
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| component2 = Polymyxin |
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| component1 = Polymyxin B |
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| class2 = ] |
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| class1 = ] |
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| component2 = Trimethoprim |
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| class2 = ] ] |
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<!-- Clinical data --> |
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| tradename = Polytrim |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_category = |
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| dependency_liability = |
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| routes_of_administration = ]s |
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| ATC_prefix = S01 |
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| ATC_prefix = S01 |
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| ATC_suffix = AA30 |
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| ATC_suffix = AA30 |
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| ATC_supplemental = |
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| PubChem = 24848162 |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| KEGG = |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = |
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| licence_EU = <!-- EMEA requires brand name --> |
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| licence_US = |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = |
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| pregnancy_category= |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
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| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> |
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| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> |
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| legal_US = |
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| legal_US = Rx only |
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| legal_US_comment = <ref name="Polytrim FDA label">{{cite web | title=Polytrim (polymyxin B sulfate and trimethoprim ophthalmic solution, USP) Sterile | website=DailyMed | url=https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=652205 | access-date=6 December 2024}}</ref> |
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| legal_status = |
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| legal_status = |
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| dependency_liability = |
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| routes_of_administration = ]s |
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<!--Identifiers--> |
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| CAS_number = 103172-75-4 |
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| PubChem = 24848162 |
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| DrugBank_Ref = |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| KEGG = D11086 |
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| synonyms = |
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<!--Chemical data--> |
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}} |
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}} |
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The ] combination ''']/]''' (], trade name '''Polytrim''') is an ] solution for topical ] use in the treatment of ] ] ] and ]. |
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'''Polymyxin B/trimethoprim''', sold under the brand name '''Polytrim''' is an ] solution for topical ] use in the treatment of ] ] ] and ].<ref name="Polytrim FDA label" /> |
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] |
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In 2022, it was the 252nd most commonly prescribed medication in the United States, with more than 1{{nbsp}}million prescriptions.<ref>{{cite web | title=The Top 300 of 2022 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=30 August 2024 | archive-date=30 August 2024 | archive-url=https://web.archive.org/web/20240830202410/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Polymyxin B; Trimethoprim Drug Usage Statistics, United States, 2013 - 2022 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/PolymyxinBTrimethoprim | access-date = 30 August 2024 }}</ref> |
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== Medical uses == |
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Polymyxin B/trimethoprim is ] in the treatment of surface ocular bacterial infections,<ref name="Yolton_1992">{{cite journal | vauthors = Yolton DP | title = New antibacterial drugs for topical ophthalmic use | journal = Optometry Clinics : The Official Publication of the Prentice Society | volume = 2 | issue = 4 | pages = 59–72 | date = 1992 | pmid = 1286241 | doi = | url = }}</ref> including acute bacterial conjunctivitis, and blepharoconjunctivitis, caused by susceptible strains of the following microorganisms: '']'', '']'', '']'', '']'', '']'', and '']''.<ref name="Polytrim FDA label" /> |
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==References== |
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{{Reflist}} |
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{{Portal bar | Medicine}} |
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{{Authority control}} |
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{{DEFAULTSORT:Polymyxin B Trimethoprim}} |
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