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Revision as of 16:18, 25 August 2011 editBinksternet (talk | contribs)Autopatrolled, Extended confirmed users, File movers, Pending changes reviewers494,034 edits Undid revision 446671549 by Arjayay (talk) Alternate spelling is not a mistake in the original, per Webster's dictionary.← Previous edit Latest revision as of 16:48, 7 November 2022 edit undoJWBE (talk | contribs)Extended confirmed users10,125 edits removed Category:Pyridines; added Category:3-Pyridyl compounds using HotCat 
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{{Chembox {{Chembox
| Watchedfields = changed
| verifiedrevid = 430484221 | verifiedrevid = 446675741
| ImageFile = VUAA1_structure.png | ImageFile = VUAA1_structure.svg
| ImageSize = 250px | ImageSize = 200px
| IUPACName = 2-(4-ethyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-ylthio)-N-(4-ethylphenyl)acetamide | PIN = ''N''-(4-Ethylphenyl)-2-<nowiki/>{sulfanyl}acetamide
| OtherNames = | OtherNames =
| Section1 = {{Chembox Identifiers |Section1={{Chembox Identifiers
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo = | CASNo = 525582-84-7
⚫ | SMILES = CCN1C(C2=CN=CC=C2)=NN=C1SCC(NC3=CC=C(CC)C=C3)=O
| UNII_Ref = {{fdacite|correct|FDA}}
⚫ | PubChem = 1319135
| UNII = ZZ52US95LQ
⚫ | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
⚫ | SMILES = CCN1C(C2=CN=CC=C2)=NN=C1SCC(NC3=CC=C(CC)C=C3)=O
⚫ | PubChem = 1319135
⚫ | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 1105882 | ChemSpiderID = 1105882
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = UWCCKVJVOHTHAF-UHFFFAOYSA-N | StdInChIKey = UWCCKVJVOHTHAF-UHFFFAOYSA-N
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI=1S/C19H21N5OS/c1-3-14-7-9-16(10-8-14)21-17(25)13-26-19-23-22-18(24(19)4-2)15-6-5-11-20-12-15/h5-12H,3-4,13H2,1-2H3,(H,21,25) | StdInChI=1S/C19H21N5OS/c1-3-14-7-9-16(10-8-14)21-17(25)13-26-19-23-22-18(24(19)4-2)15-6-5-11-20-12-15/h5-12H,3-4,13H2,1-2H3,(H,21,25)
}} }}
| Section2 = {{Chembox Properties |Section2={{Chembox Properties
| C=19
| Formula = C<sub>19</sub>H<sub>21</sub>N<sub>5</sub>OS
| H=21
| MolarMass = 367.468
| N=5
| Appearance =
| Density = | O=1
| S=1
⚫ | MeltingPt =
| BoilingPt = | Appearance =
| Solubility = | Density =
⚫ | MeltingPt =
| BoilingPt =
| Solubility =
}} }}
| Section3 = {{Chembox Hazards |Section3={{Chembox Hazards
| GHSPictograms = {{GHS07}}
⚫ | MainHazards =
| GHSSignalWord = Warning
⚫ | FlashPt =
| HPhrases = {{H-phrases|315|319|335}}
| Autoignition =
| PPhrases = {{P-phrases|261|264|271|280|302+352|304+340|305+351+338|312|321|332+313|337+313|362|403+233|405|501}}
⚫ | MainHazards =
⚫ | FlashPt =
| AutoignitionPt =
}} }}
}} }}


'''VUAA1''' is a chemical compound that works by over activating an insect's ]s causing a ] effect. It was recently discovered at ].<ref>Jones PL, Pask GM, Rinker DC, Zwiebel LJ. Functional agonism of insect odorant receptor ion channels. ''Proceedings of the National Academy of Sciences USA''. 2011 May 9. PMID 21555561</ref> '''VUAA1''' is a chemical compound that works by over activating an insect's ]s causing a ] effect. It is considered to be an Orco allosteric agonist.<ref>{{Cite web|url=https://medschool.vanderbilt.edu/syncore/publication/allosteric-antagonism-insect-odorant-receptor-ion-channels|title=Allosteric antagonism of insect odorant receptor ion channels. {{!}} Chemical Synthesis Core|last=Medicine|first=Vanderbilt University School of|website=medschool.vanderbilt.edu|access-date=2016-06-02}}</ref> It was discovered at ]<ref>{{Cite journal | pmid=21555561| pmc=3102409| year=2011| last1=Jones| first1=P. L.| title=Functional agonism of insect odorant receptor ion channels| journal=Proceedings of the National Academy of Sciences| volume=108| issue=21| pages=8821–5| last2=Pask| first2=G. M.| last3=Rinker| first3=D. C.| last4=Zwiebel| first4=L. J.| doi=10.1073/pnas.1102425108| bibcode=2011PNAS..108.8821J| doi-access=free}}</ref> with research being partially funded by the ].<ref>{{Cite web|url=http://www.cnn.com/2014/05/05/tech/innovation/big-idea-bug-spray/index.html|title=A bug repellent that could save lives - CNN.com|author=Doug Gross|website=CNN|date=5 May 2014|access-date=2016-06-02}}</ref>


VUAA1 is first-in-class agonist believed to work by overloading an insect's ]s. This new class of chemicals is said to be 1000 times stronger than ]<ref name="physorg05">{{cite press release | title = New type of insect repellent may be thousands of times stronger than DEET | date= May 9, 2011 | publisher = physorg.com | url = http://www.physorg.com/news/2011-05-biologists-class-insect-repellent.html}}</ref> and may lead to, "a powerful new family of compounds that can be used to disrupt the destructive behaviors of nuisance insects, agricultural pests, and ]s alike."<ref>{{cite press release | title = Functional agonism of insect odorant receptor ion channel | date= April 4, 2011 | url=http://www.pnas.org/content/early/2011/05/04/1102425108.full.pdf+html}}</ref> VUAA1 is an ] believed to work by overloading an insect's ]s. It may be 1000 times stronger than ]<ref name="physorg05">{{cite press release | title = New type of insect repellent may be thousands of times stronger than DEET | date= May 9, 2011 | publisher = physorg.com | url = http://www.physorg.com/news/2011-05-biologists-class-insect-repellent.html}}</ref> and may lead to, "a powerful new family of compounds that can be used to disrupt the destructive behaviors of nuisance insects, agricultural pests, and ]s alike."<ref>{{cite press release | title = Functional agonism of insect odorant receptor ion channel | date= April 4, 2011 | url=http://www.pnas.org/content/early/2011/05/04/1102425108.full.pdf+html}}</ref>

VUAA1 has also been shown to stimulate mosquito sperm motility, thus showing a link between a mosquito's sense of smell and reproduction.<ref>{{Cite web|url=http://www.vanderbilt.edu/vicb/DiscoveriesArchives/linking_sense_smell.html|title=VICB Article: Sulfilimine Cross-Links A Key to Tissue Evolution|website=www.vanderbilt.edu|access-date=2016-06-02}}</ref>


== References == == References ==
<!--- See ] on how to create references using <ref></ref> tags which will then appear here automatically -->
{{Reflist}} {{Reflist}}


== External links == == External links ==
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