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1,2,4-Trichlorobenzene

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1,2,4-Trichlorobenzene
Names
Preferred IUPAC name 1,2,4-Trichlorobenzene
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.004.026 Edit this at Wikidata
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1/C6H3Cl3/c7-4-1-2-5(8)6(9)3-4/h1-3H<
SMILES
  • Clc1ccc(Cl)c(Cl)c1
Properties
Chemical formula C6H3Cl3
Molar mass 181.44 g·mol
Appearance Colorless liquid
Odor aromatic
Density 1.46 g cm
Melting point 16.9 °C (62.4 °F; 290.0 K)
Boiling point 213.5 °C (416.3 °F; 486.6 K)
Solubility in water 0.003% (20 °C)
Vapor pressure 1 mmHg (20 °C)
Related compounds
Related compounds 1,2,3-Trichlorobenzene
1,3,5-Trichlorobenzene
Hazards
Flash point 110 °C (230 °F; 383 K)
Explosive limits 2.5%-6.6% (150°C)
NIOSH (US health exposure limits):
PEL (Permissible) none
REL (Recommended) C 5 ppm (40 mg/m)
IDLH (Immediate danger) N.D.
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

1,2,4-Trichlorobenzene is an organochlorine compound, one of three isomers of trichlorobenzene. It is a derivative of benzene with three chloride substituents. It is a colorless liquid used as a solvent for a variety of compounds and materials.

Production and uses

Depending on the conditions and additives (e.g., sulfur), it can be the main product from the chlorination of benzene. It is virtually the exclusive product from the chlorination of 1,4-dichlorobenzene. It is also the main product from the dehydrochlorination of hexachlorocyclohexane.

It is useful as a high-temperature solvent, e.g. for GPC of polyolefines such as PE or PP which are otherwise insoluble.

Aside from its use as a solvent, this compound is a useful precursor to dye and pesticides.

Safety

The LD50 (oral, rats) is 756 mg/kg. Animal studies have shown that 1,2,4-trichlorobenzene affects the liver and kidney, and is possibly a teratogen. There is no regulated occupational exposure limit for chemical exposure, but the National Institute for Occupational Safety and Health recommends no greater exposure than 5 ppm, over an 8-hour workday.

See also

  • Chlorobenzenes—different numbers of chlorine substituents and isomeric forms

References

  1. ^ NIOSH Pocket Guide to Chemical Hazards. "#0627". National Institute for Occupational Safety and Health (NIOSH).
  2. Jaw, Ching-Guang; Chen, I-Ming; Yen, Jui-Hung; Wang, Yei-Shung (December 1999). "Partial solubility parameters of chlorobenzene and chlorophenol compounds at equilibrium distribution in two immiscible phases". Chemosphere. 39 (15): 2607–2620. doi:10.1016/s0045-6535(99)00173-3. ISSN 0045-6535.
  3. Beck, U.; Löser, E. "Chlorinated Benzenes and other Nucleus-Chlorinated Aromatic Hydrocarbons". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.o06_o03. ISBN 978-3527306732.
  4. CDC - NIOSH Pocket Guide to Chemical Hazards
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