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1-Boc-4-AP

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(Redirected from 1-boc-4-AP) Chemical compound Pharmaceutical compound
1-Boc-4-AP
Legal status
Legal status
  • US: List 1
Identifiers
IUPAC name
  • tert-butyl 4-anilinopiperidine-1-carboxylate
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H24N2O2
Molar mass276.380 g·mol
3D model (JSmol)
SMILES
  • CC(C)(C)OC(=O)N1CCC(CC1)NC2=CC=CC=C2
InChI
  • InChI=1S/C16H24N2O2/c1-16(2,3)20-15(19)18-11-9-14(10-12-18)17-13-7-5-4-6-8-13/h4-8,14,17H,9-12H2,1-3H3
  • Key:HTIWISWAPVQGMI-UHFFFAOYSA-N

1-Boc-4-AP (tert-butyl 4-(phenylamino)piperidine-1-carboxylate) is a compound used as an intermediate in the manufacture of fentanyl, as well as various related derivatives such as butyrylfentanyl, furanylfentanyl, benzylfentanyl and homofentanyl, among others. It is an N-protected derivative of 4-anilinopiperidine which can be readily converted to fentanyl or related analogues in several straightforward synthetic steps. It was classified as a DEA List 1 Chemical in 2022, and is also controlled in various other jurisdictions. Its possession, sale and importation are consequently heavily regulated throughout much of the world. 1-Boc-4-AP has also been identified as an impurity in other designer drug products, though it is unclear if it has any pharmacological activity in its own right.

See also

References

  1. "Specific Listing for 1-boc-4-AP, a Currently Controlled List I Chemical". Federal Register, 87 FR 67550-67553. 9 November 2022.
  2. May C, Downey C, Power JD, Kavanagh PV (September 2020). "An unusual detection of tert-butyl-4-anilinopiperidine-1-carboxylate in seizures of falsified 'Xanax' tablets and in items in a suspected heroin seizure submitted by Irish law enforcement". Drug Testing and Analysis. 12 (9): 1387–1392. doi:10.1002/dta.2884. PMID 32567251. S2CID 219974817.
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