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12alpha-hydroxysteroid dehydrogenase

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(Redirected from 12a-hydroxysteroid dehydrogenase) Class of enzymes
12-alpha-hydroxysteroid dehydrogenase
Identifiers
EC no.1.1.1.176
CAS no.61642-40-8
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BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
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In enzymology, a 12alpha-hydroxysteroid dehydrogenase (EC 1.1.1.176) is an enzyme that catalyzes the chemical reaction

3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + NADP {\displaystyle \rightleftharpoons } 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H

Thus, the two substrates of this enzyme are 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate and NADP, whereas its 3 products are 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate, NADPH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is 12alpha-hydroxysteroid:NADP 12-oxidoreductase. Other names in common use include 12alpha-hydroxy steroid dehydrogenase, 12alpha-hydroxy steroid dehydrogenase, NAD-dependent 12alpha-hydroxysteroid dehydrogenase, and NADP-12alpha-hydroxysteroid dehydrogenase. This enzyme is involved in a metabolic pathway that degrades bile acids into cholesterol.

References

Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor
1.1.2: cytochrome acceptor
1.1.3: oxygen acceptor
1.1.4: disulfide as acceptor
1.1.5: quinone/similar acceptor
1.1.99: other acceptors
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