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15-hydroxyicosatetraenoate dehydrogenase

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Class of enzymes
15-hydroxyicosatetraenoate dehydrogenase
Identifiers
EC no.1.1.1.232
CAS no.117910-46-0
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In enzymology, a 15-hydroxyicosatetraenoate dehydrogenase (EC 1.1.1.232) is an enzyme that catalyzes the chemical reaction

(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate + NAD(P)+ {\displaystyle \rightleftharpoons } 15-oxo-5,8,11-cis-13-trans-icosatetraenoate + NAD(P)H + H

The 3 substrates of this enzyme are 15-hydroxyicosatetraenoic acid (i.e. 15(S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate), NAD, and NADP, whereas its 4 products are 15-oxo-5,8,11-cis-13-trans-icosatetraenoate, NADH, NADPH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P) 15-oxidoreductase. This enzyme is also called 15-hydroxyeicosatetraenoate dehydrogenase. This enzyme participates in arachidonic acid metabolism.

References

  • Sok DE, Kang JB, Shin HD (1988). "15-Hydroxyeicosatetraenoic acid dehydrogenase activity in microsomal fraction of mouse liver homogenate". Biochem. Biophys. Res. Commun. 156 (1): 524–9. doi:10.1016/S0006-291X(88)80873-8. PMID 3052453.
Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor
1.1.2: cytochrome acceptor
1.1.3: oxygen acceptor
1.1.4: disulfide as acceptor
1.1.5: quinone/similar acceptor
1.1.99: other acceptors
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