15-hydroxyprostaglandin-D dehydrogenase (NADP) | |||||||||
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Identifiers | |||||||||
EC no. | 1.1.1.196 | ||||||||
CAS no. | 84399-95-1 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 15-hydroxyprostaglandin-D dehydrogenase (NADP) (EC 1.1.1.196) is an enzyme that catalyzes the chemical reaction
- (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADP (5Z,13E)-9alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate + NADPH + H
Thus, the two substrates of this enzyme are (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate and NADP, whereas its 3 products are (5Z,13E)-9alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate, NADPH, and H.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP 15-oxidoreductase. Other names in common use include prostaglandin-D 15-dehydrogenase (NADP), dehydrogenase, prostaglandin D2, NADP-PGD2 dehydrogenase, dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine, dinucleotide phosphate), 15-hydroxy PGD2 dehydrogenase, 15-hydroxyprostaglandin dehydrogenase (NADP), NADP-dependent 15-hydroxyprostaglandin dehydrogenase, prostaglandin D2 dehydrogenase, NADP-linked 15-hydroxyprostaglandin dehydrogenase, NADP-specific 15-hydroxyprostaglandin dehydrogenase, NADP-linked prostaglandin D2 dehydrogenase, and 15-hydroxyprostaglandin-D dehydrogenase (NADP). This enzyme participates in arachidonic acid metabolism.
References
- Watanabe K, Shimizu T, Iguchi S, Wakatsuka H, Hayashi M, Hayaishi O (1980). "An NADP-linked prostaglandin D dehydrogenase in swine brain". J. Biol. Chem. 255 (5): 1779–82. PMID 7354056.
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