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The 1978 Alitalia Florence Open was a men's tennis tournament played on outdoor clay courts in Florence, Italy that was part of the 1978 Colgate-Palmolive Grand Prix circuit. It was the sixth edition of the tournament and was played from 15 May until 21 May 1978. Unseeded José Luis Clerc won the singles title.
José Luis Clerc
Corrado Barazzutti / 
Patrice Dominguez 6–4, 6–2, 6–1
Mark Edmondson /