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2'-N-acetylparomamine deacetylase

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Class of enzymes
2'-N-acetylparomamine deacetylase
Identifiers
EC no.3.5.1.112
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2'-N-acetylparomamine deacetylase (EC 3.5.1.112, btrD (gene), neoL (gene), kanN (gene)) is an enzyme with systematic name 2'-N-acetylparomamine hydrolase (acetate-forming). This enzyme catalyses the following chemical reaction

2'-N-acetylparomamine + H2O {\displaystyle \rightleftharpoons } paromamine + acetate

This enzyme takes part in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin.

References

  1. Truman AW, Huang F, Llewellyn NM, Spencer JB (2007). "Characterization of the enzyme BtrD from Bacillus circulans and revision of its functional assignment in the biosynthesis of butirosin". Angewandte Chemie. 46 (9): 1462–4. doi:10.1002/anie.200604194. PMID 17226887.
  2. Yokoyama K, Yamamoto Y, Kudo F, Eguchi T (April 2008). "Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis". ChemBioChem. 9 (6): 865–9. doi:10.1002/cbic.200700717. PMID 18311744.

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Hydrolases: carbon-nitrogen non-peptide (EC 3.5)
3.5.1: Linear amides /
Amidohydrolases
3.5.2: Cyclic amides/
Amidohydrolases
3.5.3: Linear amidines/
Ureohydrolases
3.5.4: Cyclic amidines/
Aminohydrolases
3.5.5: Nitriles/
Aminohydrolases
3.5.99: Other
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