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In enzymology, a 2,5-dihydroxypyridine 5,6-dioxygenase (EC 1.13.11.9) is an enzyme that catalyzes the chemical reaction

2,5-dihydroxypyridine + O₂ ${\displaystyle \rightleftharpoons }$ N-formylmaleamic acid

The 2 substrates of this enzyme are 2,5-dihydroxypyridine and O₂, whereas its product is N-formylmaleamic acid.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. It employs one cofactor, iron.

This enzyme participates in nicotinate and nicotinamide metabolism.

Nomenclature

The systematic name of this enzyme class is 2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase. Other names in common use include 2,5-dihydroxypyridine oxygenase, and pyridine-2,5-diol dioxygenase.

References

1. Q88FY1
2. Henke, Matthew T.; Snider, Mark J. (1 April 2011). "Mechanistic studies of 2,5-dihydroxypyridine 5,6-dioxygenase (NicX) from Bordetella bronchiseptica". The FASEB Journal. 25 (1 Supplement): 714.2. doi:10.1096/fasebj.25.1_supplement.714.2 (inactive 1 November 2024). ISSN 0892-6638. Retrieved 13 February 2017.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)

Further reading

• Behrman EJ, Stanier RY (1957). "The bacterial oxidation of nicotinic acid". J. Biol. Chem. 228 (2): 923–45. doi:10.1016/S0021-9258(18)70671-6. PMID 13475371.
• Gauthier JJ, Rittenberg SC (1971). "The metabolism of nicotinic acid. I. Purification and properties of 2,5-dihydroxypyridine oxygenase from Pseudomonas putida N-9". J. Biol. Chem. 246 (11): 3737–42. doi:10.1016/S0021-9258(18)62189-1. PMID 5578917.
• Gauthier JJ, Rittenberg SC (1971). "The metabolism of nicotinic acid. II. 2,5-dihydroxypyridine oxidation, product formation, and oxygen 18 incorporation". J. Biol. Chem. 246 (11): 3743–8. doi:10.1016/S0021-9258(18)62190-8. PMID 5578918.
• Behrman EJ (November 2008). "N-Formylmaleamic acid: an intermediate in nicotinic acid metabolism". Proc. Natl. Acad. Sci. U.S.A. 105 (47): E88, author reply E89. Bibcode:2008PNAS..105E..88B. doi:10.1073/pnas.0808695105. PMC 2587544. PMID 19020104.

• Biology

• EC 1.13.11
• Iron enzymes
• Enzymes of unknown structure