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In enzymology, a 2-(acetamidomethylene)succinate hydrolase (EC 3.5.1.29) is an enzyme that catalyzes the chemical reaction

2-(acetamidomethylene)succinate + 2 H₂O ${\displaystyle \rightleftharpoons }$ acetate + succinate semialdehyde + NH₃ + CO₂

Thus, the two substrates of this enzyme are 2-(acetamidomethylene)succinate and H₂O, whereas its 4 products are acetate, succinate semialdehyde, NH₃, and CO₂.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating). This enzyme is also called alpha-(N-acetylaminomethylene)succinic acid hydrolase. This enzyme participates in vitamin B₆ metabolism.

References

• Huynh MS, Snell EE (1985). "Enzymes of vitamin B₆ degradation. Purification and properties of two N-acetylamidohydrolases". J. Biol. Chem. 260 (4): 2379–83. PMID 3972793.
• Nyns EJ, Zach D, Snell EE (1969). "The bacterial oxidation of vitamin B₆. 8. Enzymatic breakdown of alpha-(N-acetylaminomethylene) succinic acid". J. Biol. Chem. 244 (10): 2601–5. PMID 5769993.

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