Misplaced Pages

2-dehydropantolactone reductase (A-specific)

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Class of enzymes
2-dehydropantolactone reductase (A-specific)
Identifiers
EC no.1.1.1.168
CAS no.37211-75-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a 2-dehydropantolactone reductase (A-specific) (EC 1.1.1.168) is an enzyme that catalyzes the chemical reaction

(R)-pantolactone + NADP {\displaystyle \rightleftharpoons } 2-dehydropantolactone + NADPH + H

Thus, the two substrates of this enzyme are (R)-pantolactone and NADP, whereas its 3 products are 2-dehydropantolactone, NADPH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is (R)-pantolactone:NADP oxidoreductase (A-specific). Other names in common use include 2-oxopantoyl lactone reductase, ketopantoyl lactone reductase, 2-ketopantoyl lactone reductase, and 2-dehydropantoyl-lactone reductase (A-specific).

References

  • King HL Jr, Dyar RE, Wilken DR (Aug 10, 1974). "Ketopantoyl lactone and ketopantoic acid reductases: Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase". J. Biol. Chem. 249 (15): 4689–4695. PMID 4603075.
  • Wilken DR, King HL Jr, Dyar RE (March 25, 1975). "Ketopantoic acid and ketopantoyl lactone reductases: Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate". J. Biol. Chem. 250 (6): 2311–2314. PMID 234966.
Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor
1.1.2: cytochrome acceptor
1.1.3: oxygen acceptor
1.1.4: disulfide as acceptor
1.1.5: quinone/similar acceptor
1.1.99: other acceptors
Enzymes
Activity
Regulation
Classification
Kinetics
Types
Portal:


This EC 1.1.1 enzyme-related article is a stub. You can help Misplaced Pages by expanding it.

Categories: