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2-hydroxyhexa-2,4-dienoate hydratase

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Class of enzymes
2-hydroxyhexa-2,4-dienoate hydratase
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EC no.4.2.1.132
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2-hydroxyhexa-2,4-dienoate hydratase (EC 4.2.1.132, tesE (gene), hsaE (gene)) is an enzyme with systematic name 4-hydroxy-2-oxohexanoate hydro-lyase ((2Z,4Z)-2-hydroxyhexa-2,4-dienoate-forming). This enzyme catalyses the following chemical reaction

4-hydroxy-2-oxohexanoate {\displaystyle \rightleftharpoons } (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O

This enzyme catalyses a late step in the bacterial steroid degradation pathway.

References

  1. Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T (September 2005). "Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441". Applied and Environmental Microbiology. 71 (9): 5275–81. doi:10.1128/aem.71.9.5275-5281.2005. PMC 1214608. PMID 16151114.

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Carbon–oxygen lyases (EC 4.2) (primarily dehydratases)
4.2.1: Hydro-Lyases
4.2.2: Acting on polysaccharides
4.2.3: Acting on phosphates
4.2.99: Other
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