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Romain Arneodo and Fernando Romboli were the defending champions but only Romboli chose to defend his title, partnering Fabrício Neis. Romboli lost in the first round to Sergio Galdós and Federico Zeballos.

Guido Andreozzi and Guillermo Durán won the title after defeating Facundo Bagnis and Andrés Molteni 7–6, 6–4 in the final.

Seeds

1. Marcelo Demoliner / Gonzalo Escobar (semifinals)
2. Fabrício Neis / Fernando Romboli (first round)
3. Guido Andreozzi / Guillermo Durán (champions)
4. Facundo Bagnis / Andrés Molteni (final)

Draw

Key

• Q = Qualifier
• WC = Wild card
• LL = Lucky loser
• Alt = Alternate
• SE = Special exempt
• PR = Protected ranking
• ITF = ITF entry
• JE = Junior exempt
• w/o = Walkover
• r = Retired
• d = Defaulted
• SR = Special ranking

	First round							Quarterfinals							Semifinals							Final
	1	M Demoliner G Escobar	6	6
	WC	D Acosta F Roncadelli	4	1				1	M Demoliner G Escobar	6	6
	WC	F Llanes T Seyboth Wild	6	2					F Gaio P Lorenzi	1	1
		F Gaio P Lorenzi	2	6											1	M Demoliner G Escobar	6	6
	3	G Andreozzi G Durán	6	6											3	G Andreozzi G Durán	2	7
		R Cid Subervi P Krstin	0	1				3	G Andreozzi G Durán	7	6
		T Lipovšek Puches Matías Zukas	6	6					T Lipovšek Puches M Zukas	6	4
		C Berlocq G Pella	3	2																		3	G Andreozzi G Durán	7	6
		J Domingues G Elias	3	6																		4	F Bagnis A Molteni	6	4
		A De Greef L Giustino	6	1					J Domingues G Elias	4	7
	WC	R Arús G Clezar	3	3				4	F Bagnis A Molteni	6	6
	4	F Bagnis A Molteni	6	6											4	F Bagnis A Molteni	6	6
		M Cuevas H Dellien	3	3												S Galdós F Zeballos	7	3
		F Agamenone F Argüello	6	6					F Agamenone F Argüello	4	6
		S Galdós F Zeballos	3	7					S Galdós F Zeballos	6	7
	2	F Neis F Romboli	6	5

References

• Main draw

• 2018 ATP Challenger Tour
• Uruguay Open
• 2018 in Uruguayan tennis