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222 was a year of the Julian calendar, in the third century AD.

222 also commonly refers to:

• 222 (number), the natural number following 221 and preceding 223

222 may also refer to:

Entertainment

• 222 (album), a 2023 album by Lil Tjay
• 222 (Live & Uncut), a version of Patton Oswalt's comedy album Feelin' Kinda Patton
• 222 (EP), María Becerra, 2019
• "222" (song), from the 2007 Paul McCartney album Memory Almost Full
• 222 Records, an American record label founded in 2012 by Adam Levine
• Room 222, a TV show
• The 222s, a Montreal band
• "222", a song by Flatbush Zombies on the 2013 EP BetterOffDead

Transportation and vehicles

• British Rail Class 222, a class of trains used in Great Britain
• A222 road, a road between Bexley and Croydon, UK
• 222 (MBTA bus), a bus route in Boston, Massachusetts, USA
• Bell 222, an American twin-engine light helicopter
• Sd.Kfz. 222, a World War II German reconnaissance vehicle
• 2-2-2, a classification of steam locomotive
• U.S. Route 222, a road in the U.S. states of Maryland and Pennsylvania
• A bus route in London from Hounslow to Uxbridge
• Maserati 222, a coupé

Weapons

• 130 mm coastal defense gun A-222
• A-222 Bereg, a Russian self-propelled 130 mm coastal defence gun
• .222 Remington and .222 Remington Magnum, firearm cartridges

Other

• 2:22 (disambiguation)
• 222, a formulation of the compound analgesic co-codaprin
• 222 Lucia, an asteroid

• Lists of ambiguous numbers