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Trade names | Pressionorm, Wintonin |
Other names | 3-Hydroxyamphetamine; meta-Hydroxyamphetamine; α-Methyl-meta-tyramine; 3-Hydroxy-α-methylphenethylamine |
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ECHA InfoCard | 100.012.779 |
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Formula | C9H13NO |
Molar mass | 151.209 g·mol |
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Gepefrine, also known as 3-hydroxyamphetamine or α-methyl-meta-tyramine and sold under the brand names Pressionorm and Wintonin, is a sympathomimetic medication used as an antihypotensive agent which has been marketed in Germany.
Pharmacology
Gepefrine is described as a sympathomimetic and antihypotensive agent.
Chemistry
Gepefrine, also known as 3-hydroxy-α-methylphenethylamine or as 3-hydroxyamphetamine, is a substituted phenethylamine and amphetamine derivative. It is used pharmaceutically as the (S)-enantiomer and as the tartrate salt. Related compounds include meta-tyramine (3-hydroxyphenethylamine), 4-hydroxyamphetamine (norpholedrine), 3,4-dihydroxyamphetamine (α-methyldopamine), and metaraminol ((1R,2S)-3,β-dihydroxyamphetamine), among others.
History
Gepefrine was synthesized by 1968 and was introduced for medical use in Germany by 1981.
Society and culture
Names
Gepefrine is the generic name of the drug and its INNTooltip International Nonproprietary Name. Brand names of gepefrine include Pressionorm and Wintonin.
Other drugs
Gepefrine is a known metabolite of amphetamine in rats.
References
- ^ Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 487. ISBN 978-3-88763-075-1. Retrieved 24 April 2012.
- Macdonald F (1997). Dictionary of Pharmacological Agents. CRC Press. p. 127. ISBN 978-0-412-46630-4. Retrieved 24 April 2012.
- ^ Publishing, W.A.W.A. (2013). Pharmaceutical Manufacturing Encyclopedia. Volumes 1-4. Elsevier Science. p. 1760. ISBN 978-0-8155-1856-3. Retrieved 2024-09-01.
- ^ Jonsson J (October 1977). "Identification of metahydroxyamphetamine as a metabolite of amphetamine in the rat". Research Communications in Chemical Pathology and Pharmacology. 18 (2): 189–199. PMID 918344.
- ^ Elks, J. (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. pp. 73–74. ISBN 978-1-4757-2085-3. Retrieved 2024-09-01.
- Challener, C.A. (2017). Chiral Drugs. Routledge Revivals. Taylor & Francis. p. 552. ISBN 978-1-351-80804-0. Retrieved 1 September 2024.
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