3-dehydro-L-gulonate 2-dehydrogenase | |||||||||
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3-dehydro-L-gulonate 2-dehydrogenase dimer, E.Coli | |||||||||
Identifiers | |||||||||
EC no. | 1.1.1.130 | ||||||||
CAS no. | 37250-61-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 3-dehydro-L-gulonate 2-dehydrogenase (EC 1.1.1.130) is an enzyme that catalyzes the chemical reaction:
- 3-dehydro-L-gulonate + NAD(P) (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H
The 3 substrates of this enzyme are 3-dehydro-L-gulonate, NAD, and NADP, whereas its 4 products are (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate, NADH, NADPH, and H.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is 3-dehydro-L-gulonate:NAD(P) 2-oxidoreductase. Other names in common use include 3-keto-L-gulonate dehydrogenase, 3-ketogulonate dehydrogenase, 3-keto-L-gulonate dehydrogenase, and 3-ketogulonate dehydrogenase. This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism.
References
- Volk WA, Larsen JL (1962). "beta-Keto-L-gulonic acid as an intermediate in the bacterial metabolism of ascorbic acid". J. Biol. Chem. 237 (8): 2454–7. doi:10.1016/S0021-9258(19)73773-9. PMID 13926592.
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