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3-Ketosteroid reductase

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(Redirected from 3-keto-steroid reductase) Enzyme
3-keto-steroid reductase
Identifiers
EC no.1.1.1.270
CAS no.42616-29-5
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In enzymology, a 3-keto-steroid reductase (EC 1.1.1.270) is an enzyme that catalyzes the chemical reaction

4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP {\displaystyle \rightleftharpoons } 4alpha-methyl-5alpha-cholest-7-en-3-one + NADPH + H

Thus, the two substrates of this enzyme are 4alpha-methyl-5alpha-cholest-7-en-3beta-ol and NADP, whereas its 3 products are 4alpha-methyl-5alpha-cholest-7-en-3-one, NADPH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is 3beta-hydroxy-steroid:NADP 3-oxidoreductase. This enzyme is also called 3-KSR. This enzyme participates in biosynthesis of steroids.

References

  • Billheimer JT, Alcorn M, Gaylor JL (1981). "Solubilization and partial purification of a microsomal 3-ketosteroid reductase of cholesterol biosynthesis". Arch. Biochem. Biophys. 211 (1): 430–8. doi:10.1016/0003-9861(81)90474-4. PMID 6946726.
  • Swindell AC, Gaylor JL (1968). "Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3-ketosteroid intermediates". J. Biol. Chem. 243 (21): 5546–55. PMID 4387005.
Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor
1.1.2: cytochrome acceptor
1.1.3: oxygen acceptor
1.1.4: disulfide as acceptor
1.1.5: quinone/similar acceptor
1.1.99: other acceptors
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