3-oxo-5-beta-steroid 4-dehydrogenase | |||||||||
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Identifiers | |||||||||
EC no. | 1.3.99.6 | ||||||||
CAS no. | 9067-97-4 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 3-oxo-5beta-steroid 4-dehydrogenase (EC 1.3.99.6) is an enzyme that catalyzes the chemical reaction
- a 3-oxo-5beta-steroid + acceptor a 3-oxo-Delta4-steroid + reduced acceptor
Thus, the two substrates of this enzyme are 3-oxo-5beta-steroid and acceptor, whereas its two products are 3-oxo-Delta4-steroid and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is 3-oxo-5beta-steroid:acceptor Delta4-oxidoreductase. This enzyme is also called 3-oxo-5beta-steroid:(acceptor) Delta4-oxidoreductase. This enzyme participates in 3 metabolic pathways: bile acid biosynthesis, c21-steroid hormone metabolism, and androgen and estrogen metabolism.
References
- Davidson SJ, Talalay P (1966). "Purification and mechanism of action of a steroid delta-4-5-beta-dehydrogenase". J. Biol. Chem. 241 (4): 906–15. PMID 5907467.
Oxidoreductases: CH–CH oxidoreductases (EC 1.3) | |
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1.3.1: NAD/NADP acceptor | |
1.3.3: Oxygen acceptor | |
1.3.5: Quinone | |
1.3.99: Other acceptors |
Enzymes | |
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Activity | |
Regulation | |
Classification | |
Kinetics | |
Types |
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