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3alpha-hydroxycholanate dehydrogenase

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Class of enzymes
3-alpha-hydroxycholanate dehydrogenase
Identifiers
EC no.1.1.1.52
CAS no.9028-57-3
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BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
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In enzymology, a 3alpha-hydroxycholanate dehydrogenase (EC 1.1.1.52) is an enzyme that catalyzes the chemical reaction

3alpha-hydroxy-5beta-cholanate + NAD {\displaystyle \rightleftharpoons } 3-oxo-5beta-cholanate + NADH + H

Thus, the two substrates of this enzyme are 3alpha-hydroxy-5beta-cholanate and NAD, whereas its 3 products are 3-oxo-5beta-cholanate, NADH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is 3alpha-hydroxy-5beta-cholanate:NAD oxidoreductase. This enzyme is also called alpha-hydroxy-cholanate dehydrogenase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1IHI.

References

Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor
1.1.2: cytochrome acceptor
1.1.3: oxygen acceptor
1.1.4: disulfide as acceptor
1.1.5: quinone/similar acceptor
1.1.99: other acceptors
Enzymes
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