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4-Cyano-3-(trifluoromethyl)aniline

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4-Cyano-3-(trifluoromethyl)aniline
Names
Preferred IUPAC name 4-Amino-2-(trifluoromethyl)benzonitrile
Other names 4-Cyano-3-(trifluoromethyl)aniline
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.109.189 Edit this at Wikidata
PubChem CID
UNII
CompTox Dashboard (EPA)
SMILES
  • C1=CC(=C(C=C1N)C(F)(F)F)C#N
Properties
Chemical formula C8H5F3N2
Molar mass 186.137 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

4-Cyano-3-(trifluoromethyl)aniline, also known as 4-amino-2-(trifluoromethyl)benzonitrile, is a cyanated and trifluoromethylated derivative of aniline. It is the starting material in one of the chemical syntheses of the nonsteroidal antiandrogen bicalutamide.

References

  1. Tucker H, Crook JW, Chesterson GJ (1988). "Nonsteroidal antiandrogens. Synthesis and structure-activity relationships of 3-substituted derivatives of 2-hydroxypropionanilides". Journal of Medicinal Chemistry. 31 (5): 954–9. doi:10.1021/jm00400a011. PMID 3361581.


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