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In enzymology, a 4-hydroxybenzaldehyde dehydrogenase (EC 1.2.1.64) is an enzyme that catalyzes the chemical reaction

4-hydroxybenzaldehyde + NAD + H₂O ${\displaystyle \rightleftharpoons }$ 4-hydroxybenzoate + NADH + 2 H

The 3 substrates of this enzyme are 4-hydroxybenzaldehyde, NAD, and H₂O, whereas its 3 products are 4-hydroxybenzoate, NADH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-hydroxybenzaldehyde:NAD+ oxidoreductase. This enzyme is also called p-hydroxybenzaldehyde dehydrogenase. This enzyme participates in toluene and xylene degradation in bacteria. It is also found in carrots (Daucus carota).

References

1. Bossert ID, Whited G, Gibson DT, Young LY (1989). "Anaerobic oxidation of p-cresol mediated by a partially purified methylhydroxylase from a denitrifying bacterium". J. Bacteriol. 171 (6): 2956–62. PMC 210000. PMID 2722739.
2. Whited GM, Gibson DT (1991). "Separation and partial characterization of the enzymes of the toluene-4-monooxygenase catabolic pathway in Pseudomonas mendocina KR1". J. Bacteriol. 173 (9): 3017–20. PMC 207886. PMID 2019564.
3. Sircar, D.; Mitra, A. (2008). "Evidence for p-hydroxybenzoate formation involving enzymatic phenylpropanoid side-chain cleavage in hairy roots of Daucus carota". Journal of Plant Physiology. 165 (4): 407–414. doi:10.1016/j.jplph.2007.05.005. PMID 17658659.

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