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In enzymology, a 4-hydroxyglutamate transaminase (EC 2.6.1.23) is an enzyme that catalyzes the chemical reaction

4-hydroxy-L-glutamate + 2-oxoglutarate ${\displaystyle \rightleftharpoons }$ 4-hydroxy-2-oxoglutarate + L-glutamate

Thus, the two substrates of this enzyme are 4-hydroxy-L-glutamate and 2-oxoglutarate, whereas its two products are 4-hydroxy-2-oxoglutarate and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase. This enzyme is also called 4-hydroxyglutamate aminotransferase. This enzyme participates in arginine and proline metabolism.

References

• GOLDSTONE A, ADAMS E (1962). "Metabolism of gamma-hydroxyglutamic acid. I. Conversion to alpha-hydroxy-gamma-ketoglutarate by purified glutamic-aspartic transaminase to rat liver". J. Biol. Chem. 237: 3476–85. PMID 13948827.
• KURATOMI K, FUKUNAGA K, KOBAYASHI Y (1963). "THE METABOLISM OF GAMMA-HYDROXYGLUTAMATE IN RAT LIVER. II. A TRANSAMINASE CONCERNED IN GAMMA-HYDROXYGLUTAMATE METABOLISM". Biochim. Biophys. Acta. 78 (4): 629–36. doi:10.1016/0006-3002(63)91028-X. PMID 14089443.

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