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6-Hydroxynicotinate 3-monooxygenase

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(Redirected from 6-hydroxynicotinate 3-monooxygenase) Class of enzymes
6-Hydroxynicotinate 3-monooxygenase
Identifiers
EC no.1.14.13.114
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6-Hydroxynicotinate 3-monooxygenase (EC 1.14.13.114, NicC, 6HNA monooxygenase, HNA-3-monooxygenase) is an enzyme with systematic name 6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating). This enzyme catalyses the following chemical reaction

6-hydroxynicotinate + NADH + H + O2 {\displaystyle \rightleftharpoons } 2,5-dihydroxypyridine + NAD + H2O + CO2

6-Hydroxynicotinate 3-monooxygenase a flavoprotein (FAD).

References

  1. Nakano H, Wieser M, Hurh B, Kawai T, Yoshida T, Yamane T, Nagasawa T (February 1999). "Purification, characterization and gene cloning of 6-hydroxynicotinate 3-monooxygenase from Pseudomonas fluorescens TN5". European Journal of Biochemistry. 260 (1): 120–6. doi:10.1046/j.1432-1327.1999.00124.x. PMID 10091591.
  2. Jiménez JI, Canales A, Jiménez-Barbero J, Ginalski K, Rychlewski L, García JL, Díaz E (August 2008). "Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440". Proceedings of the National Academy of Sciences of the United States of America. 105 (32): 11329–34. Bibcode:2008PNAS..10511329J. doi:10.1073/pnas.0802273105. PMC 2516282. PMID 18678916.

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Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)
1.14.11: 2-oxoglutarate
1.14.13: NADH or NADPH
1.14.14: reduced flavin or flavoprotein
1.14.15: reduced iron–sulfur protein
1.14.16: reduced pteridine (BH4 dependent)
1.14.17: reduced ascorbate
1.14.18-19: other
1.14.99 - miscellaneous
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