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8-Bromotheophylline

Clinical data
Other names	Bromotheophylline
Identifiers
IUPAC name 8-Bromo-1,3-dimethyl-7H-purine-2,6-dione
CAS Number	10381-75-6
PubChem CID	11808
DrugBank	DB14018
ChemSpider	11315
UNII	FZG87K1MQ6
ChEMBL	ChEMBL316160
CompTox Dashboard (EPA)	DTXSID7044768
ECHA InfoCard	100.030.757
Chemical and physical data
Formula	C7H7BrN4O2
Molar mass	259.063 g·mol
3D model (JSmol)	Interactive image
SMILES CN1C2=C(C(=O)N(C1=O)C)NC(=N2)Br
InChI InChI=1S/C7H7BrN4O2/c1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h1-2H3,(H,9,10) Key:SKTFQHRVFFOHTQ-UHFFFAOYSA-N

8-Bromotheophylline is a xanthine diuretic drug. It is the main active ingredient in pamabrom where it is sold as an over-the-counter medication in combination with paracetamol, among other analgesics, to treat dysmenorrhea. It is also an adenosine receptor A₁ antagonist.

See also

• 8-Chlorotheophylline
• 8-Cyclopentyltheophylline
• 8-Phenyltheophylline

References

1. Ortiz MI, Murguía-Cánovas G, Vargas-López LC, Silva R, González-de la Parra M (October 2016). "Naproxen, paracetamol and pamabrom versus paracetamol, pyrilamine and pamabrom in primary dysmenorrhea: a randomized, double-blind clinical trial". Medwave. 16 (9): e6587. doi:10.5867/medwave.2016.09.6587. PMID 27813503.
2. Ortiz MI (September 2010). "Primary dysmenorrhea among Mexican university students: prevalence, impact and treatment". European Journal of Obstetrics, Gynecology, and Reproductive Biology. 152 (1): 73–77. doi:10.1016/j.ejogrb.2010.04.015. PMID 20478651.
3. Jacobson KA, Shi D, Gallo-Rodriguez C, Manning M, Müller C, Daly JW, et al. (September 1993). "Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors". Journal of Medicinal Chemistry. 36 (18): 2639–2644. doi:10.1021/jm00070a007. PMID 8410976.

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