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8-oxocoformycin reductase

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Class of enzymes
8-oxocoformycin reductase
Identifiers
EC no.1.1.1.235
CAS no.114995-16-3
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In enzymology, a 8-oxocoformycin reductase (EC 1.1.1.235) is an enzyme that catalyzes the chemical reaction

coformycin + NADP {\displaystyle \rightleftharpoons } 8-oxocoformycin + NADPH + H

Thus, the two substrates of this enzyme are coformycin and NADP, whereas its 3 products are 8-oxocoformycin, NADPH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is coformycin:NADP 8-oxidoreductase. This enzyme is also called 8-ketodeoxycoformycin reductase.

References

  • Hanvey JC, Hawkins ES, Baker DC, Suhadolnik RJ (July 1988). "8-Ketodeoxycoformycin and 8-ketocoformycin as intermediates in the biosynthesis of 2'-deoxycoformycin and coformycin". Biochemistry. 27 (15): 5790–5. doi:10.1021/bi00415a059. PMID 3052586.
Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor
1.1.2: cytochrome acceptor
1.1.3: oxygen acceptor
1.1.4: disulfide as acceptor
1.1.5: quinone/similar acceptor
1.1.99: other acceptors
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