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ABTB1
Identifiers
Aliases	ABTB1, BPOZ, BTB3, BTBD21, EF1ABP, PP2259, ankyrin repeat and BTB domain containing 1
External IDs	OMIM: 608308; MGI: 1933148; HomoloGene: 32731; GeneCards: ABTB1; OMA:ABTB1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q21.3 Start 127,672,935 bp End 127,680,926 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 D1 Start 88,812,896 bp End 88,818,966 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum granulocyte blood spleen apex of heart tibial nerve right lung gastric mucosa canal of the cervix monocyte Top expressed in granulocyte Jacobson's organ blood muscle of thigh neural layer of retina right kidney spermatocyte superior frontal gyrus lip proximal tubule More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding translation elongation factor activity ubiquitin protein ligase binding Cellular component plasma membrane nucleolus SCF ubiquitin ligase complex cytoplasm cytosol ubiquitin ligase complex Biological process translational elongation protein biosynthesis proteasome-mediated ubiquitin-dependent protein catabolic process regulation of proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80325 80283 Ensembl ENSG00000114626 ENSMUSG00000030083 UniProt Q969K4 Q99LJ2 RefSeq (mRNA) NM_032548 NM_172027 NM_172028 NM_030251 NM_001362152 RefSeq (protein) NP_115937 NP_742024 NP_084527 NP_001349081 Location (UCSC) Chr 3: 127.67 – 127.68 Mb Chr 6: 88.81 – 88.82 Mb PubMed search
Wikidata
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Ankyrin repeat and BTB/POZ domain-containing protein 1 is a protein that in humans is encoded by the ABTB1 gene.

Function

This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants encoding different isoforms.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000114626 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000030083 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dai KS, Wei W, Liew CC (Sep 2000). "Molecular cloning and characterization of a novel human gene containing ankyrin repeat and double BTB/POZ domain". Biochem Biophys Res Commun. 273 (3): 991–6. doi:10.1006/bbrc.2000.3053. PMID 10891360.
6. Unoki M, Nakamura Y (Aug 2001). "Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway". Oncogene. 20 (33): 4457–65. doi:10.1038/sj.onc.1204608. PMID 11494141.
7. ^ "Entrez Gene: ABTB1 ankyrin repeat and BTB (POZ) domain containing 1".

External links

• Human ABTB1 genome location and ABTB1 gene details page in the UCSC Genome Browser.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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